Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: An packaging apparatus and method to uncuff a package assembly is disclosed. The package assembly includes a container with at least one upstanding sidewall defining an open top. A bag is disposed within the container and a top portion of the bag is folded over the at least one sidewall at the open top to define a cuff. The packaging apparatus includes a first fluid jet directed substantially upward that is configured to uncuff the top portion of the bag from the container. An automatic bag closer gathers the top portion of the bag and applies a clip to close the bag. A second fluid jet is directed substantially downward and is configured to push the top portion of the bag substantially within the container.

Abstract: Apparatus for counting small articles such as pills comprises a helical inclined plane having a pill receiving portion at or adjacent its upper end, pill detector means downstream of said pill receiving portion, said detector means being connected to a counter for giving a visual display of the number of pills passing over said detector means and pill collecting means for collecting pills after passage down said inclined plane, whereby pills deposited on said pill receiving portion are propelled under gravity down said inclined plane, are separated into substantially single file, are counted by said detector and counter means, and are collected in said collecting means.