Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.

Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.

Abstract: This invention relates to a solid phase method of synthesizing biomolecule-drug conjugates. In particular, this invention relates to a solid phase method of synthesizing antibody-drug conjugates (ADCs). This invention also relates to intermediate methods of producing immobilized, chemically modified biomolecules, e.g. antibodies. The invention also relates to various uses of capture resins and to biomolecule-drug conjugates, intermediate products and compositions prepared by the methods of the invention.

Abstract: The invention is in the field of virology and relates to the deformed wing virus (DWV). A new strain of deformed wing virus (DWV) has been identified that is predominant in bees infested with Varroa mites. This particular strain of DWV can be used in diagnostics to identify at risk colonies. Also, inhibitors of the particular strain may be used in the treatment and/or prevention of DWV.

Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.

Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.

Abstract: An embodiment of an applicator wheel, which applies ink to embossed designs on gutters. This is accomplished during manufacturing process of gutter as gutters exit any gutter machine. The embodiment attaches to any gutter machine, and by a simple process applies ink or paint to any design that is raised/embossed. Ink is held in a well, which distributes through a roller to a transfer roller to applicator wheel pad. Two offset rims keep the pad at correct distance from un-embossed portion of gutter and applicator wheel pad paints only the embossed portion of a design. (FIG. 10). Between flexibility of pad and this offset rim distance, ink is applied only to raised/embossed portion of any design by application wheel roller, rolling along the gutter as it exits gutter machine. Another embodiment applies a design directly onto un-embossed gutters. Again, using the applicator wheel, except this embodiment uses a different applicator wheel pad with a design on the pad. (FIG. 11).

Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.

Abstract: The invention relates to a method for identifying compounds that act as modulators of hepatitis C (HCV) translation and/or replication, and to compounds identified by this method, and their uses in medicine. The invention also relates to an RNA useful for identifying modulators of HCV translation and/or replication. The invention further relates to a method for producing a replication-competent HCV virus.

Abstract: A tissue fastening device includes a suture clip holder and a suture cutter. A suture clip can be releasably secured to the suture clip holder, and a suture line or lines can pass through the clip and adjacent the suture cutter. A first movement of a control handle causes the suture clip to be released from the suture clip holder, and a second movement of the control handle causes the suture cutter to cut the suture line or lines. The first movement is different from the second movement. The first movement can be rotational, with the second movement being longitudinal. Alternatively, the first movement can be longitudinal, with the second movement being rotational. The device may include a main body, an inner body, and an outer body.

Abstract: Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature without the need for a separate introducer sheath. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.

Abstract: Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.

Abstract: A tissue fastening device includes a suture clip holder and a suture cutter. A suture clip can be releasably secured to the suture clip holder, and a suture line or lines can pass through the clip and adjacent the suture cutter. A first movement of a control handle causes the suture clip to be released from the suture clip holder, and a second movement of the control handle causes the suture cutter to cut the suture line or lines. The first movement is different from the second movement. The first movement can be rotational, with the second movement being longitudinal. Alternatively, the first movement can be longitudinal, with the second movement being rotational. The device may include a main body, an inner body, and an outer body.

Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.

Abstract: A virtual set-top box (vSTB) for executing a middleware component, designed originally for use with the physical STB, including emulating hardware capabilities of the physical STB to process IPTV content received over a connection for presenting the IPTV content on a display of the electronic device.

Abstract: A virtual set-top box (vSTB) for executing a middleware component, designed originally for use with the physical STB, including emulating hardware capabilities of the physical STB to process IPTV content received over a connection for presenting the IPTV content on a display of the electronic device.

Abstract: The use of collectins and/or surfactant proteins for the treatment and prevention of ocular disease.

Abstract: A virtual set-top box (vSTB) for executing a middleware component, designed originally for use with the physical STB, including emulating hardware capabilities of the physical STB to process IPTV content received over a connection for presenting the IPTV content on a display of the electronic device.

Abstract: A method for enabling a program that communicates a document description from a composition system to a printing system to manage variable-dot halftones for use with variable-dot printing devices, comprising the steps of using a selected halftone cell size to choose an array comprising at least one string defining a halftone cell intensity value, said string comprising at least one pixel imbution value, wherein said pixel imbution value is in the range of 0 to P, wherein P is the number of physical appearances that a painted pixel can have; using a selected halftone cell intensity value to choose a string; and painting at least one pixel within a halftone cell according to a pixel imbution value within the chosen string.

Abstract: Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.