Patents by Inventor David J. Graves

David J. Graves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Device and methods for enhanced microarray hybridization reactions
    Publication number: 20030119028
    Abstract: A device and methods are provided for enhancing DNA microarray hybridization speed and discrimination efficiency by means of an electric field.
    Type: Application
    Filed: August 7, 2002
    Publication date: June 26, 2003
    Inventors: David J. Graves, Paolo Fortina, Richard (Hung-Ju) Su
  • Novel method to enhance microarray surface density and hybridization efficiency
    Publication number: 20030099930
    Abstract: Disclosed are nucleic acid microarray devices and their method of preparation employing dendrimeric polyamines to bind nucleic acid probes to solid support surfaces thereby enhancing the surface molecule density and hybridization efficiency of nucleic acids in the microarray. Also disclosed are methods of using the resulting microarray device for analyzing test samples containing target molecules.
    Type: Application
    Filed: October 29, 2001
    Publication date: May 29, 2003
    Inventors: David J. Graves, David Cossaboon, Richard Hung Ju Su, Paolo Fortina, Saul Surrey, Steve McKenzie
  • Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
    Patent number: 5167811
    Abstract: Disclosed is a method of conducting affinity chromatographic separations of biomaterials which comprises contacting the biomaterial with a solid support comprising a generally spherical bead having a generally central magnetic core and a surrounding exterior coat about the core comprising a material capable of binding with the biomaterial.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: December 1, 1992
    Assignee: Trustees of the University of Pennsylvania
    Inventors: David J Graves, Mark A. Burns
  • Affinity chromatogry using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
    Patent number: 5167812
    Abstract: Disclosed is a method of conducting affinity chromatographic separations of biomaterials which comprises contacting the biomaterial with a solid support comprising a generally spherical bead having a generally central magnetic core and a surrounding exterior coat about the core comprising a material capable of binding with the biomaterial.
    Type: Grant
    Filed: January 17, 1992
    Date of Patent: December 1, 1992
    Assignee: Trustees of the Univ. of Penna.
    Inventors: David J. Graves, Mark A. Burns
  • Support for high performance liquid chromatography in a magnetically stabilized fluidized bed
    Patent number: 5055194
    Abstract: A method of, and an apparatus for, conducting chromatographic separations of multi-component systems utilizing silica-coated, magnetically susceptible particles in an MSFB is disclosed. A support material comprised of beads having a magnetic core surrounded by a silica derivative porous coating is used.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: October 8, 1991
    Assignee: University of Pennsylvania
    Inventors: Victor Goetz, David J. Graves
  • Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
    Patent number: 4675113
    Abstract: Disclosed is a method of conducting affinity chromatographic separations of biomaterials which comprises contacting the biomaterial with a solid support comprising a generally spherical bead having a generally central magnetic core and a surrounding exterior coat about the core comprising a material capable of binding with the biomaterial.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: June 23, 1987
    Assignee: University Patents, Inc.
    Inventors: David J. Graves, Mark A. Burns
  • Gas concentration analysis method and system
    Patent number: 4208902
    Abstract: A method and system for analyzing gas concentration by measuring the steady state pressure in a dual membrane cell. A first membrane is exposed to a test gas and a second membrane to a reference gas where the first and second membranes have differing permeabilities. The test gas and the reference gas continuously counterdiffuse through the membranes and the steady state pressure in the intermembrane space is directly proportional to the gas concentration of the test gas component.
    Type: Grant
    Filed: December 20, 1978
    Date of Patent: June 24, 1980
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Bang M. Kim, John A. Quinn, David J. Graves