Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: One aspect of the present application relates to a pharmaceutical composition comprising a sulfated glycosaminoglycan having an average molecular weight ranging from 3,000 to 15,000 Daltons, a skin penetrating agent, where the skin penetrating agent promotes transdermal penetration of the sulfated glycosaminoglycan when applied to intact skin surfaces, and a pharmaceutical carrier for topical application, where the pharmaceutical carrier is mixed with the sulfated glycosaminoglycan and the skin penetrating agent. This composition is useful in carrying out a method of treating a subject for pain, joint stiffness, soft tissue injury, connective tissue disorders, and/or muscle soreness.

Abstract: A beverage production device prepares a beverage from a beverage concentrate contained in a receptacle. The beverage production device includes a support member for supporting the receptacle, a plate member arranged vertically to the support means, the plate member including at least four outlet nozzles for injecting a fluid jet into the receptacle. A liquid supply member is connected to the outlet nozzles, and at least two of the outlet nozzles are designed to direct a fluid jet to an inner side wall of the receptacle and are arranged at different angles with respect the vertical. At least two of the outlet nozzles are designed to direct a fluid jet to the bottom of the receptacle and are arranged at different angles with respect to the vertical.

Abstract: A beverage production device prepares a beverage from a beverage concentrate contained in a receptacle. The beverage production device includes a support member for supporting the receptacle, a plate member arranged vertically to the support means, the plate member including at least four outlet nozzles for injecting a fluid jet into the receptacle. A liquid supply member is connected to the outlet nozzles, and at least two of the outlet nozzles are designed to direct a fluid jet to an inner side wall of the receptacle and are arranged at different angles with respect the vertical. At least two of the outlet nozzles are designed to direct a fluid jet to the bottom of the receptacle and are arranged at different angles with respect to the vertical.

Abstract: The present invention proposes a beverage production device for preparing a beverage from a beverage concentrate contained in a receptacle, comprising a support means (1) for supporting the receptacle (13), a plate member (2) arranged vertically to the support means, the plate member (2) comprising at least four outlet nozzles (4) for injecting a fluid jet (A) into the receptacle (13), liquid supply means (6) connected to the outlet nozzles (4), wherein at least two of the outlet nozzles (4) are designed to direct a fluid jet (A3, A4) to an inner side wall (13b) of the receptacle (13) and said outlet nozzles (4) are arranged at different angles (a) with respect the vertical, and wherein at least two of the outlet nozzles (4) are designed to direct a fluid jet (A1, A2) to the bottom of the receptacle (13a) and said outlet nozzles (4) are arranged at different angles (?) with respect to the vertical.

Abstract: A mixing nozzle (1) for mixing a concentrate and a diluent and dispensing the mixture is disclosed. The mixing nozzle includes: a concentrate conduit including a concentrate inlet port (2) and a concentrate outlet port (3) and a concentrate flowpath (4) therebetween, the conduit defining the longitudinal axis (XX?) of the mixing nozzle; a toroidal chamber (5) around said concentrate conduit having a water inlet conduit (6) tangentially disposed with respect thereto to create a swirling of the water in said chamber, said toroidal chamber presenting multiple openings (7) at the bottom wall of the toroidal chamber to create multiple flows of diluent around the concentrate outlet port (3); an assembly of multiple radially projecting ribs (10) provided downstream to the multiple openings (7) of the toroidal chamber, the ribs being curved at their downstream ends (10a) towards the mixing nozzle longitudinal axis (XX?).

Abstract: The invention concerns a beverage production device (10) having a first dissolution chamber (1), said first dissolution chamber being configured for producing a beverage by mixing a beverage concentrate and a diluent and having: —at least one diluent inlet (11a, 11b) and—at least one liquid delivery outlet (12), —a bottom wall (13), the at least one liquid delivery outlet (12) being set in said bottom wall, wherein the device has a second dilution chamber (2), said second dilution chamber having: —a top wall (21), and—at least one liquid inlet (22) through the top wall, said liquid inlet being the liquid delivery outlet (12) of the first dissolution chamber, and—at least one diluent inlet (23) configured for introducing a diluent in the second dilution chamber and mixing said diluent with the liquid flowing from the at least one liquid inlet (22) through the top wall.

Abstract: Device for producing a frothed liquid comprising a chamber opened to atmosphere with a transverse bottom wall and a longitudinal upward wall, at least one diluent inlet, at least one liquid delivery outlet. The diluent inlet is provided through the upward wall and is dimensioned and oriented for directing a thin jet of diluent in the chamber. The at least one liquid delivery outlet is configured in the bottom wall for liquid to rise up along the side of the upward wall by the jet of diluent entering the chamber as a result of the direction and dimension of the diluent inlet in the chamber.

Abstract: The invention concerns a mixing nozzle (1) for mixing a concentrate and a diluent and dispensing the mixture comprising: a concentrate conduit including a concentrate inlet port (2) and a concentrate outlet port (3) and a concentrate flowpath (4) therebetween, said conduit defining the longitudinal axis (XX?) of the mixing nozzle; a toroidal chamber (5) around said concentrate conduit having a water inlet conduit (6) tangentially disposed with respect thereto to create a swirling of the water in said chamber, said toroidal chamber presenting multiple openings (7) at the bottom wall of the toroidal chamber to create multiple flows of diluent around the concentrate outlet port (3); an assembly of multiple radially projecting ribs (10) provided downstream to the multiple openings (7) of the toroidal chamber, the ribs being curved at their downstream ends (10a) towards the mixing nozzle longitudinal axis (XX?).

Abstract: Device for producing a frothed liquid comprising a chamber opened to atmosphere with a transverse bottom wall and a longitudinal upward wall, at least one diluent inlet, at least one liquid delivery outlet. The at least one diluent inlet comprises a first diluent inlet provided through the upward wall and dimensioned and oriented for directing a thin jet of diluent in the chamber. The at least one liquid delivery outlet is configured in the bottom wall for liquid to rise up along the side of the upward wall by the jet of diluent entering the chamber as a result of the direction and dimension of the diluent inlet in the chamber.

Abstract: A method and a device are provided for dispensing multiple portions of a fluid that is stored in a container having a port and a flexible dispensing tube. The flexible dispensing tube includes an inlet and an outlet. The inlet is integrally sealed to the port and a viscoelastic valve is mounted in the outlet. The method includes a compression step and a step of terminating compression. The method also includes a step implemented at the end of the compression step that releases the pressure in a tube portion between a first tube portion and the valve.

Abstract: A system for testing a communications network includes a controller having a computing device with a controller application and an operator having a microcontroller and a device interface module controlled by the microcontroller. A handheld communications device is operatively connected to the operator through the device interface module and adapted to communicate over the communications network being tested. The controller and the operator are connected by an out-of-band wireless control link to allow communication therebetween outside of the communications network being tested. The operator is adapted to receive commands from the controller over the out-of-band control link and, upon receipt of a command from the controller over the out-of-band control link, to initiate in-band communication on the handheld communications device over the communications network through the device interface module.

Abstract: Device for producing a frothed liquid comprising a chamber opened to atmosphere with a transverse bottom wall and a longitudinal upward wall, at least one diluent inlet, at least one liquid delivery outlet. The at least one diluent inlet comprises a first diluent inlet provided through the upward wall and dimensioned and oriented for directing a thin jet of diluent in the chamber. The at least one liquid delivery outlet is configured in the bottom wall for liquid to rise up along the side of the upward wall by the jet of diluent entering the chamber as a result of the direction and dimension of the diluent inlet in the chamber.

Abstract: Device for producing a frothed liquid comprising a chamber opened to atmosphere with a transverse bottom wall and a longitudinal upward wall, at least one diluent inlet, at least one liquid delivery outlet. The diluent inlet is provided through the upward wall and is dimensioned and oriented for directing a thin jet of diluent in the chamber. The at least one liquid delivery outlet is configured in the bottom wall for liquid to rise up along the side of the upward wall by the jet of diluent entering the chamber as a result of the direction and dimension of the diluent inlet in the chamber.

Abstract: Device for producing a frothed liquid comprising a chamber 13 opened to atmosphere with a transverse bottom wall 14 and a longitudinal upward wall 15, at least one diluent inlet 18, at least one liquid delivery outlet 20, wherein the diluent inlet is provided through the upward wall and is dimensioned and oriented for directing a thin jet of diluent in the chamber, and wherein the at least one liquid delivery outlet is configured in the bottom wall for liquid to rise up along the side of the upward wall by the jet of diluent entering the chamber as a result of the direction and dimension of the diluent inlet in the chamber.

Abstract: The invention concerns a beverage production device (10) comprising a first dissolution chamber (1), said first dissolution chamber being configured for producing a beverage by mixing a beverage concentrate and a diluent and comprising:—at least one diluent inlet (11a, 11b) and—at least one liquid delivery outlet (12),—a bottom wall (13), the at least one liquid delivery outlet (12) being set in said bottom wall, wherein the device comprises a second dilution chamber (2), said second dilution chamber comprising a top wall (21), and—at least one liquid inlet (22) through the top wall, said liquid inlet being the liquid delivery outlet (12) of the first dissolution chamber, and—at least one diluent inlet (23) configured for introducing a diluent in the second dilution chamber and mixing said diluent with the liquid flowing from the at least one liquid inlet (22) through the top wall.

Abstract: A system for testing a communications network includes a controller having a computing device with a controller application and an operator having a microcontroller and a device interface module controlled by the microcontroller. A handheld communications device is operatively connected to the operator through the device interface module and adapted to communicate over the communications network being tested. The controller and the operator are connected by an out-of-band wireless control link to allow communication therebetween outside of the communications network being tested. The operator is adapted to receive commands from the controller over the out-of-band control link and, upon receipt of a command from the controller over the out-of-band control link, to initiate in-band communication on the handheld communications device over the communications network through the device interface module.

Abstract: A method and a device for dispensing multiple portions of a fluid, the fluid being stored in a container comprising a port and a flexible dispensing tube having an inlet and an outlet, the inlet being integrally sealed to the port and visco-elastic valve is mounted in the outlet. The method comprising a compression step and a step of terminating compression wherein the method comprises a further step implemented at the end of the compression step of releasing the pressure in the tube portion between the first tube portion and the valve.

Abstract: The present invention proposes a beverage production device for preparing a beverage from a beverage concentrate contained in a receptacle, comprising a support means (1) for supporting the receptacle (13), a platemember (2) arranged vertically to the support means, the platemember (2) comprising at least four outlet nozzles (4) for injecting a fluid jet (A) into the receptacle (13), liquid supply means (6) connected to the outlet nozzles (4), wherein at least two of the outlet nozzles (4) are designed to direct a fluid jet (A3, A4) to an inner side wall (13b) of the receptacle (13) and said outlet nozzles (4) are arranged at different angles (a) with respect the vertical, and wherein at least two of the outlet nozzles (4) are designed to direct a fluid jet (A1, A2) to the bottom of the receptacle (13a) and said outlet nozzles (4) are arranged at different angles (b) with respect to the vertical.

Abstract: The invention relates to a method for delivering a flavored and/or nutritionally enhanced non-carbonated beverage on premise. The method comprises a step of providing at least one packaged source of a liquid premix base comprising at least one microbiologically, physically, enzymatically and/or chemically sensitive beverage component which is not solely carbohydrate, a water activity lowering component. The liquid premix based is formulated with a water activity and/or solid content effective to render it shelf stable at room temperature. The method comprises a step of separately providing a plurality of flowable additive packaged sources adapted to tailor the flavor, aroma, body and/or nutritional value of the beverage. The method comprises a step in which liquid premix base is mixed to hot or cold non-carbonated water to provide a beverage base which is dispensed to the cup and wherein at least one additive is delivered and mixed with the beverage base into the cup.