Patents by Inventor David J Holmes

David J Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • metRS2
    Patent number: 7304152
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: December 4, 2007
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham
  • metRS2
    Patent number: 7128920
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: October 31, 2006
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham
  • metRS2
    Publication number: 20040157233
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Application
    Filed: June 30, 2003
    Publication date: August 12, 2004
    Inventors: Daniel R. Gentry, David J. Holmes, Karen A. Ingraham
  • Methods for producing modified nucleic acid molecules
    Patent number: 6770462
    Abstract: A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desired site in the molecule, but does not require ligation. Also described is the use of this method for high throughput screening the resulting modified nucleic acid molecules.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: August 3, 2004
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Alison F. Chalker, David J. Holmes, Robert Dwayne Lunsford, James Yigong Ge
  • lacR from Streptococcus pneumoniae
    Patent number: 6548273
    Abstract: The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: April 15, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Pan Fong Chan, David J. Holmes, Michael A. Lonetto, Christopher M. Traini, Magdalena Zalacain
  • Fucose kinase
    Patent number: 6511839
    Abstract: The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: January 28, 2003
    Inventors: Pan Fong Chan, Sanjoy Biswas, David J. Holmes, Michael A. Lonetto, Leslie M. Palmer, Stephanie Van Horn, Richard L. Warren, Jr., Magdalena Zalacain
  • KdtB
    Publication number: 20020115191
    Abstract: The invention provides kdtB polypeptides and polynucleotides encoding kdtB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing kdtB polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: August 9, 2001
    Publication date: August 22, 2002
    Inventors: John P. Throup, Stephanie Van Horn, Richard L. Warren, David J. Holmes, Alison F. Chalker, Chi Young So, Karen A. Ingraham
  • galK
    Publication number: 20020107217
    Abstract: The invention provides galK promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
    Type: Application
    Filed: September 17, 2001
    Publication date: August 8, 2002
    Inventors: Pan Fong Chan, David J. Holmes, Michael A. Lonetto, Stephanie Van Horn, Richard L. Warren, Magdalena Zalacain
  • yacM1
    Publication number: 20020064863
    Abstract: The invention provides yacM1 polypeptides and polynucleotides encoding yacM1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing yacM1 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and materials.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 30, 2002
    Inventors: Martin K. Burnham, David J. Holmes, Michael A. Lonetto, Robert D. Lunsford, Damien McDevitt, Daniel Sylvester, Stephanie Van Horn, Magdalena Zalacain
  • yacM2
    Publication number: 20020064827
    Abstract: The invention provides yacM2 polypeptides and polynucleotides encoding yacM2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing yacM2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assaysto screen for microbial infections in organisms and materials.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 30, 2002
    Inventors: Martin K. R. Burnham, David J. Holmes, Robert D. Lunsford, Damien McDevitt, Daniel Sylvester, Stephanie Van Horn, Magdalena Zalacain
  • defl
    Publication number: 20020058796
    Abstract: The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 21, 2001
    Publication date: May 16, 2002
    Inventors: Michael A. Lonetto, David J. Holmes, Deborah D. Jaworski, Richard O. Nicholas, Min Wang, Robert K. Stodola, Anna L. Kosmatka, Richard L. Warren, David J.C. Knowles, Christopher M. Traini, John E. Hodgson
  • TktA from Streptococcus pneumoniae
    Patent number: 6326167
    Abstract: The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of Streptococcus pneumoniae.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: December 4, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Alison F Chalker, Sauli J Haataja, David W Holden, David J Holmes, Karen A Ingraham, Gee W Lau, Andrea Marra, Michael A Lonetto, Damien McDevitt, Jennifer Ray, Jun Yu
  • Galk promoter
    Patent number: 6291230
    Abstract: The invention provides galK promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: September 18, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc,
    Inventors: Magdalena Zalacain, Pan Fong Chan, David J. Holmes, Michael A. Lonetto, Stephanie Van Horn, Richard L. Warren, Jr.
  • def1
    Patent number: 6284878
    Abstract: The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: September 4, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Michael Arthur Lonetto, Deborah Dee Jaworski, Min Wang, Richard Lloyd Warren, Christopher Michael Traini, Anna Lisa Kosmatka, David Justin Charles Knowles, John Edward Hodgson, Michael Terence Black, David J. Holmes, Richard Oakley Nicholas, Robert King Stodola
  • kdtB
    Patent number: 6277597
    Abstract: The invention provides kdtB polypeptides and polynucleotides encoding kdtB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing kdtB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 3, 1999
    Date of Patent: August 21, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Alison F Chalker, David J Holmes, Karen A Ingraham, Chi Young So, John P Throup, Stephanie Van Horn, Richard L Warren
  • DnaB
    Patent number: 6204014
    Abstract: The invention provides DnaB polypeptides and polynucleotides encoding DnaB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DnaB polypeptides to screen for anibacterial compounds.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: March 20, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Alison F Chalker, David J Holmes, Karen A Ingraham, Deborah D Jaworski, Anna L Lenox, Earl W May, Marie J Mazzulla, Jennifer Ray, Min Wang, Richard L Warren, Jr.
  • FabF
    Patent number: 6168797
    Abstract: The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: January 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Martin K R Burnham, Jason C Fedon, David J Holmes, Karen A Ingraham, Howard Kallender, John T Lonsdale, Marie J Mazzulla, Karen M O'Dwyer, Leslie M Palmer, Chi Young So, Christopher M Traini, Glenn S Van Aller, Stephanie Van Horn, Magdalena Zalacain
  • pcrA protein from Streptococcus pneumoniae
    Patent number: 6121414
    Abstract: The invention provides pcrA polypeptides and DNA (RNA) encoding pcrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pcrA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: September 19, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Robert King Stodola, David J Holmes
  • PCR A
    Patent number: 5858718
    Abstract: The invention provides pcrA polypeptides and DNA (RNA) encoding pcrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pcrA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: January 12, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Robert King Stodola, David J. Holmes
  • Method and apparatus for detecting and counting articles
    Patent number: 5454016
    Abstract: A method and apparatus for counting irregularly-shaped articles. A pair of light sources are provided at a sensing plane through which articles to be counted are adapted to pass. Each of the light sources emits a light beam that is at an angle to the other light beam, such as an angle of about 90.degree.. Corresponding solar cells are positioned opposite the respective light sources to receive the light signals as the articles pass through the sensing plane. The light sources are alternately operated and the outputs from the respective light detectors are used to calculate an equivalent volume for the article for comparison with a predetermined article volume range to decide whether to count the article. The method and apparatus permit accurate counts of irregularly shaped articles and are substantially independent of the orientation of the article at the sensing plane.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: September 26, 1995
    Assignee: Batching Systems Inc.
    Inventor: David J. Holmes