Patents by Inventor David J. Kyle
David J. Kyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20150265638Abstract: A method of preparing a feed composition includes (a) mixing one or more carotenoids and one or more phospholipids in an organic solvent to form a solution; and (b) thereafter combining the carotenoid(s) and phospholipid(s) with at least one other animal feed component. The organic solvent is a polar solvent selected from the group consisting of chlorocarbons and lower alcohols, and step (a) further includes removing the polar solvent from the solution.Type: ApplicationFiled: April 29, 2015Publication date: September 24, 2015Applicant: ADVANCED BIONUTRITION CORPORATIONInventors: MOTI HAREL, John Piechocki, David J. Kyle
-
Patent number: 9072311Abstract: Carotenoids are provided as dietary supplements to animal feed. These supplements improve the bioavailability of carotenoids by providing them in combination with phospholipids. The invention provides animal feeds for aquatic and terrestrial animals, and methods for making the feeds.Type: GrantFiled: June 21, 2004Date of Patent: July 7, 2015Assignee: ADVANCED BIONUTRITION CORPORATIONInventors: Moti Harel, John Piechocki, David J. Kyle
-
Publication number: 20150143555Abstract: This invention is directed to the composition, method of production, aid rrse of improved edible fish, crustacean, or mollusk products enriched with one or more components that provide health benefits to humans or other animals consuming the product.Type: ApplicationFiled: November 12, 2014Publication date: May 21, 2015Applicant: ADVANCED BIONUTRITION CORPORATIONInventors: David J. KYLE, Moti HAREL, John PIECHOCKI
-
Patent number: 8198067Abstract: A microbial biomass, made from algae, bacteria, fungi, yeast, or combinations thereof, provides a feed for animals raised either in agriculture or aquaculture. A feed additive, and a therapeutic composition can also be made from a microbial biomass of algae, bacteria, fungi, yeast, or combinations thereof. The feed, feed additive, and therapeutic composition can comprise one or more proteins, peptides, antibodies, antibody fragments, or a combination thereof, wherein said proteins, peptides, antibodies, antibody fragments, or a combination thereof are non-native to the microbes of the biomass. The biomass can have therapeutic, bioactive, nutritional, and/or immunogenic properties.Type: GrantFiled: June 9, 2006Date of Patent: June 12, 2012Assignee: Advanced Bionutrtion CorporationInventor: David J. Kyle
-
Publication number: 20120034653Abstract: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization.Type: ApplicationFiled: July 22, 2011Publication date: February 9, 2012Applicant: Martek Biosciences CorporationInventors: Kirk Emil APT, F.C. Thomas Allnutt, David J. Kyle, James Casey Lippmeier
-
Patent number: 8008061Abstract: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization.Type: GrantFiled: August 21, 2007Date of Patent: August 30, 2011Assignee: Martek Biosciences CorporationInventors: Kirk Emil Apt, F. C. Thomas Allnutt, David J. Kyle, James Casy Lippmeier
-
Patent number: 7939710Abstract: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization.Type: GrantFiled: April 23, 2001Date of Patent: May 10, 2011Assignee: Martek Biosciences CorporationInventors: Kirk Emil Apt, F. C. Thomas Allnutt, David J. Kyle, James Casey Lippmeier
-
Patent number: 7932056Abstract: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.Type: GrantFiled: June 23, 2009Date of Patent: April 26, 2011Assignee: Advanced BionutritionInventors: Ruth Barratt, F. C. Thomas Allnutt, Robert Bullis, David J. Kyle
-
Publication number: 20110015160Abstract: A method of treating a neurological disorder comprises administering to a person affected from such a disorder a microbial oil comprising DHA, a microbial oil comprising ARA or a combination of DHA and ARA oils in an amount sufficient to elevate the levels of circulating DHA and/or ARA in the person's blood to at least normal levels.Type: ApplicationFiled: July 12, 2010Publication date: January 20, 2011Inventors: David J. Kyle, Henry Linsert, JR.
-
Publication number: 20100086638Abstract: The disclosure relates to an animal feed or feed ingredient containing from about 0.01% to 1.0% DHA, wherein all, or substantially all of the DHA comes from material that is of non-animal origin and the use of microbially-derived DHA at these low levels provides sufficient DHA for the optimal neurological development of the animal.Type: ApplicationFiled: April 3, 2007Publication date: April 8, 2010Inventors: David J. Kyle, John Piechocki, Emile Laurin, Walter G. Rakitsky
-
Publication number: 20090324636Abstract: A method of production and composition of a extremely stable fish oil blend and method of use of said blend. The instant invention provides phospholipid additives to fish oil or other long-chain polyunsaturated fatty acid in an admixture that enhances the stability of the final product. Most preferably said composition utilizes a crude extract of an algal producer of long-chain polyunsaturated acids containing soaps and phospholipids added to fish oil or other purified long-chain polyunsaturated fatty acid to provide a surprisingly stable product.Type: ApplicationFiled: May 11, 2006Publication date: December 31, 2009Applicant: ADVANCED DIONUTRITION CORPORATIONInventors: John Piechocki, David J. Kyle
-
Publication number: 20090258396Abstract: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.Type: ApplicationFiled: June 23, 2009Publication date: October 15, 2009Applicant: ADVANCED BIONUTRITIONInventors: Ruth Barratt, F.C. Thomas Allnutt, Robert Bullis, David J. Kyle
-
Publication number: 20090238890Abstract: The disclosure relates to novel microencapsulation processes based on the use of high viscosity fluids (e.g., gelatinized starch and alginate), which are mixed and then sprayed using a much gentler hydraulic pressure and, preferably gas-based atomization into a crosslinking solution (e.g. of calcium chloride). To improve the efficiency of the system, the process can be performed in a continuous mode rather than by a conventional batch process. This involves continuous or intermittent harvest of the microparticles collected in the capture vessel followed by amendment and recycling of the CaCl2 solution and its redeployment into the capture vessel. The process allows production of microencapsulated probiotic bacteria without major losses in viability, thereby providing a useful and efficient new manufacturing method for the stabilization of probiotic bacteria prior to their introduction into functional foods.Type: ApplicationFiled: January 16, 2007Publication date: September 24, 2009Applicant: ADVANCED BIONUTRITION CORPORATIONInventors: John Piechocki, David J. Kyle
-
Patent number: 7550647Abstract: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.Type: GrantFiled: February 17, 2004Date of Patent: June 23, 2009Assignee: Advanced BioNutritionInventors: Ruth Barratt, F. C. Thomas Allnutt, Robert Bullis, David J. Kyle
-
Publication number: 20080194504Abstract: The invention is directed to compositions (e.g., feeds, feed supplements, and therapeutic products) and methods for inhibiting an animal pathogen using RNA-interference technology.Type: ApplicationFiled: February 4, 2005Publication date: August 14, 2008Applicant: ADVANCED BIONUTRITION CORPORATIONInventors: David J. Kyle, Arun K. Dhar
-
Patent number: 7396548Abstract: An animal feed with a high level of arachidonic acid is produced from microalgae, and fed to aquatic animals grown in aquaculture. The arachidonic acid-rich microalgae are fed directly to the aquatic animals, or processed to produce an oil that can be used as a human nutritive supplement. The arachidonic acid-rich microalgae can be combined with long chain omega-3 fatty acids to provide a source of nutrition for humans and animals. The animal feed and nutritional supplements are free of animal byproducts.Type: GrantFiled: March 19, 2003Date of Patent: July 8, 2008Assignee: Advanced BioNutrition CorporationInventor: David J. Kyle
-
Publication number: 20080138851Abstract: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization.Type: ApplicationFiled: August 21, 2007Publication date: June 12, 2008Applicant: Martek Biosciences CorporationInventors: Kirk Emil Apt, F.C. Thomas Allnutt, David J. Kyle, James Casey Lippmeier
-
Publication number: 20040177392Abstract: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.Type: ApplicationFiled: February 17, 2004Publication date: September 9, 2004Inventors: Ruth Barratt, F.C. Thomas Allnutt, Robert Bullis, David J. Kyle
-
Publication number: 20040081638Abstract: An animal feed is provided with a macroalgal, plant, or animal, e.g., insect or crustacean, biomass with one or more non-native peptides, proteins, antibodies, therapeutics, or a combination thereof. The proteins can be therapeutic, bioactive, proteins. A gene encoding a protein, antibody, therapeutic, or combination thereof, can be incorporated into a virus, which in turn, infects an organism that is a component of the feed. The virus can infect the macroalgal, plant, or animal feed component without incorporating viral genes into the macroalgal, plant, or animal feed component.Type: ApplicationFiled: October 14, 2003Publication date: April 29, 2004Inventor: David J. Kyle
-
Publication number: 20040047881Abstract: A microbial biomass, made from algae, bacteria, fungi, yeast, or combinations thereof, provides a feed for animals raised either in agriculture or aquaculture. A feed additive, and a therapeutic composition can also be made from a microbial biomass of algae, bacteria, fungi, yeast, or combinations thereof. The feed, feed additive, and therapeutic composition can comprise one or more proteins, peptides, antibodies, antibody fragments, or a combination thereof, wherein said proteins, peptides, antibodies, antibody fragments, or a combination thereof are non-native to the microbes of the biomass. The biomass can have therapeutic, bioactive, nutritional, and/or immunogenic properties.Type: ApplicationFiled: September 5, 2003Publication date: March 11, 2004Applicant: Advanced BioNutrition Corp.Inventor: David J. Kyle