Patents by Inventor David J. Lim

David J. Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-VISTA ANTIBODIES AND USES THEREOF
    Publication number: 20240132593
    Abstract: The present disclosure provides antibodies to V-domain Ig-containing Suppressor of T cell Activation (VISTA) and compositions comprising such antibodies. Also provided are methods of using antibodies that specifically binds to VISTA to treat diseases, e.g., to treat cancer.
    Type: Application
    Filed: February 18, 2022
    Publication date: April 25, 2024
    Inventors: Shawn P. Iadonato, Thierry Guillaudeux, Eric J. Tarcha, David Scott Johnson, Adam Shultz Adler, Rena Aviva Mizrahi, Yoong Wearn Lim, Michael Asensio
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Patent number: 7985729
    Abstract: The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: July 26, 2011
    Assignee: House Research Institute
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz, Kiweon Cha
  • USE OF ANITMICROBIAL PROTEINS AND PEPTIDES FOR THE TREATMENT OF OTITIS MEDIA AND PARANASAL SINUSITIS
    Publication number: 20100204447
    Abstract: The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
    Type: Application
    Filed: April 21, 2010
    Publication date: August 12, 2010
    Applicant: HOUSE EAR INSTITUTE
    Inventors: DAVID J. LIM, HAA-YUNG LEE, PAUL WEBSTER, ALI ANDALIBI, JIAN-DONG LI, TOMAS GANZ, KIWEON CHA
  • USE OF ANTIMICROBIAL PROTEINS AND PEPTIDES FOR THE TREATMENT OF OTITIS MEDIA AND PARANASAL SINUSITIS
    Publication number: 20090023893
    Abstract: The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
    Type: Application
    Filed: July 16, 2008
    Publication date: January 22, 2009
    Applicant: House Ear Institute
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz, Kiweon Cha
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Patent number: 7338936
    Abstract: The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: March 4, 2008
    Assignee: House Ear Institute
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz, Kiweon Cha
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Patent number: 7060674
    Abstract: Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: June 13, 2006
    Assignee: House Ear Institute
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Publication number: 20040265296
    Abstract: Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
    Type: Application
    Filed: April 6, 2004
    Publication date: December 30, 2004
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Patent number: 6716813
    Abstract: Disclosed herein is a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin and defensins, were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: April 6, 2004
    Assignee: House Ear Institute
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz
  • Conjugate vaccine for nontypeable Haemophilus influenzae
    Patent number: 6607725
    Abstract: A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: August 19, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin-Xing Gu, Chao-Ming Tsai, David J. Lim, John B. Robbins
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Publication number: 20020141986
    Abstract: Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
    Type: Application
    Filed: November 27, 2001
    Publication date: October 3, 2002
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz
  • Immortalized human middle ear epithelial cell lines
    Patent number: 6358688
    Abstract: Human middle ear epithelial cell lines permanently transformed by human papilloma viruses have been obtained. These cell lines are useful for the study of gene and protein expression in otitis media and the identification of chemical and biological agents that may be useful in the therapy of human otitis media and other diseases of the ear.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: March 19, 2002
    Assignee: House Ear Institute
    Inventors: David J. Lim, Young-Myoung Chun, Johng S. Rhim, Derald E. Brackmann
  • Conjugate vaccine for nontypeable haemophilus influenzae
    Publication number: 20020001589
    Abstract: A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
    Type: Application
    Filed: February 20, 2001
    Publication date: January 3, 2002
    Inventors: Xin-Xing Gu, Chao-Ming Tsai, David J. Lim, John B. Robbins
  • Conjugate vaccine for nontypeable Haemophilus influenzae
    Patent number: 6207157
    Abstract: A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: March 27, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin-Xing Gu, Chao-Ming Tsai, David J. Lim, John B. Robbins