Abstract: A system includes memory, and processing circuitry coupled to the memory, the processing circuitry configured to: determine at least one of: a cross-electrical signal measurement at a first electrode on a first lead implanted within a tongue of the patient based on a stimulation signal between a second electrode on the first lead or a second lead implanted within the tongue of the patient and a third electrode, or a strain measurement of at least one of the first lead or the second lead. The processing circuitry is configured to determine movement of the tongue based on at least one of the cross-electrical signal measurement or the strain measurement, and generate information indicative of the movement of the tongue.

Abstract: An example system includes a first lead configured to be positioned in or beside a left internal jugular vein (IJV) of a patient to deliver a first stimulation signal to a first vagus nerve, the first lead including one or more first segmented electrodes positioned on a distal portion of the first lead and a first anchoring mechanism; a second lead configured to be positioned in or beside a right IJV of the patient to deliver a second stimulation signal to a second vagus nerve, the second lead including one or more second segmented electrodes positioned on a distal portion of the second lead and a second anchoring mechanism; and circuitry configured to deliver electrical energy to the first lead to deliver the first stimulation signal and the second lead to deliver the second stimulation signal to provide bilateral stimulation to the first vagus nerve and the second vagus nerve.

Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: Systems and methods are provided for monitoring the effects of conductive dust deposits that compromise the ability of a trip unit to accurately detect AC current in a circuit interrupter. When a Rogowski coil is used as a current sensor in the circuit interrupter and the trip unit processes the output of the Rogowski coil using a printed circuit board assembly (PCBA) processing circuit, the DC component of the processing circuit output signal can be analyzed to determine whether any conductive dust has formed unintended electrical pathways on the PCBA and compromised the ability of the PCBA to accurately measure AC current in the circuit interrupter. It can be determined that such unintended electrical pathways have formed when the DC component of the processing circuit output either exceeds a predetermined threshold or has increased by a significant amount after opening of the separable contacts.

Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided herein are compositions comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4). In another aspect, such compositions further comprise a reduced level of host cell proteins and/or increased level of polysorbate-80 (PS-80) stability.

Abstract: An example system includes a collar; a first stimulating electrode array positioned on the collar and configured to delivery stimulation therapy to a patient; a second stimulating electrode array being positioned on the collar and configured to deliver stimulation therapy to the patient; a sensor array being positioned on the collar and configured to detect one or more features indicative of laryngeal muscle activity of the patient; and a controller configured to control stimulation therapy to be delivered via the first stimulating electrode array and the second stimulating electrode array.

Abstract: The present disclosure provides for synchronization of multi-core systems by monitoring a plurality of debug trace data streams for a redundantly operating system including a corresponding plurality of cores performing a task in parallel; in response to detecting a state difference on one debug trace data stream of the plurality of debug trace data streams relative to other debug trace data streams of the plurality of debug trace data streams: marking a given core associated with the one debug trace data stream as an affected core; and restarting the affected core.

Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: Methods and apparatus for interfaces to manage inter-regional connectivity for direct network peerings. A system may include a connectivity coordinator, a first resource collection in a first geographical zone and a second resource collection in a second geographical zone. The coordinator implements a programmatic interface defining connectivity operations. The coordinator receives a request via the interface to establish a logically isolated network path to the second resource collection on behalf of a client that has a dedicated physical link set up to connect to the first resource collection. In response to the request, the coordinator performs one or more configuration operations to enable traffic to flow from the client's network to the second resource collection over a logically isolated network path using the dedicated physical link.

Abstract: Provided herein are energy storage devices. In some cases, the energy storage devices are capable of being transported on a vehicle and storing a large amount of energy. An energy storage device is provided comprising at least one liquid metal electrode, an energy storage capacity of at least about 1 MWh and a response time less than or equal to about 100 milliseconds (ms).

Abstract: Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases with alternative configurations. Also described are methods of making and using compositions comprising these linkers.

Abstract: An example device includes processing circuitry configured to receive, from an oxygen sensor, an ambient air signal indicative of an oxygen partial pressure of ambient air. The processing circuitry is further configured to receive, from an atmospheric pressure sensor, an atmospheric pressure sensor signal indicative of atmospheric pressure. The processing circuitry is configured to determine, based on the atmospheric pressure sensor signal, an oxygen partial pressure of the ambient air, determine, based at least in part on the oxygen partial pressure of the ambient air and the ambient air signal, the one or more calibration parameters, and calibrate, based on the one or more calibration parameters, the oxygen sensor. The calibrated oxygen sensor may be used to, for example, determine the oxygen content of urine of a patient to monitor renal function of the patient.

Abstract: A method of tuning a resonant frequency of a nano-electromechanical systems (NEMS) drum device is performed by applying a gate voltage between the drum membrane [100] and a back gate [104] to alter the resonant frequency of the membrane to a desired frequency; photoionizing the drum membrane with a laser to detune the membrane resonant frequency to a ground state frequency; and releasing the gate voltage to set the membrane to the desired resonant frequency. The method provides the basis for various applications including NEMS memory and photodetection techniques. The NEMS device may be implemented as a graphene/hBN membrane [100] suspended on a SiO2 layer [102] deposited on a Si substrate [104].

Abstract: In some examples, a system comprises a catheter including an elongated body defining a lumen, the elongated body comprising a proximal portion and a distal portion; an anchoring member positioned on the proximal portion of the elongated body, the anchoring member configured to anchor the proximal portion of the elongated body to a patient; and a sensor configured to sense a biomarker in a fluid within the lumen of the elongated body, wherein the biomarker is indicative of an acute kidney infection (AKI) of the patient.

Abstract: A medical system for obstructive sleep apnea (OSA) treatment includes therapy delivery circuitry configured to output one or more electrical stimulation signals to a tongue of a patient; sensing circuitry configured to sense one or more compound muscle action potential (CMAP) signals, wherein the one or more CMAP signals are generated in response to the delivery of the one or more electrical stimulation signals; and processing circuitry configured to: cause the therapy delivery circuitry to output the one or more electrical stimulation signals to the tongue; receive information indicative of the one or more CMAP signals from the sensing circuitry; determine, based on the one or more CMAP signals, one or more therapeutic stimulation parameters for the OSA treatment; and cause the therapy delivery circuitry to deliver therapeutic electrical stimulation signals according to at least the determined one or more therapeutic stimulation parameters.

Abstract: A system for sensing one or more physiological traits and obstetric conditions, such as a fertility phase, pregnancy, labor, post-partum conditions, and other conditions related to the reproductive system of the patient. The system may use the one or more physiological traits sensed to define one or more patient attributes for the patient, such as a hormone level, heart rate, blood pressure, respiration rate, temperature, oxygen saturation level, uterine contractions, fluid level, and/or other patient attributes. The system is configured to compare the one or more patient attributes to one or more attribute signs describing a threshold for the one or more patient attributes. The system is configured to issue a communication to the patient and/or a clinician based on the comparisons. The system may be configured to assess and indicate reproductive phases for the patient over a life-cycle from the fertility phase to the post-partum phase.

Abstract: In one example, the disclosure relates to a catheter system comprising an elongated body defining a lumen. The elongated body comprising a proximal portion and a distal portion. An anchoring member is positioned on the proximal portion of the elongated body. The anchoring member configured to anchor the proximal portion of the elongated body to a patient. The catheter system includes one or more sensors positioned on the elongated body. The one or more sensors are configured to sense a parameter of a fluid within the lumen of the elongated body. The catheter system includes memory positioned on the elongated body, the memory configured to store patient-specific information.

Abstract: Example systems, catheters, and methods are disclosed for actively sampling a fluid. An example system includes a pump configured to pump fluid to direct the fluid a dissolved oxygen sensor and the dissolved oxygen sensor configured to output a signal indicative of an amount of dissolved oxygen in the fluid.

Abstract: In one example, a system includes an elongated body defining a lumen where the elongated body includes a proximal portion and a distal portion. An anchoring member may be positioned on the proximal portion of the elongated body. The system further includes a sensor located on the elongated body where the sensor may be configured to sense at least one flow parameter of a fluid within the lumen. In some examples, the system includes processing circuitry configured to determine at least one of a density parameter or a temperature parameter of the fluid in the lumen based on the sensed at least one flow parameter of the fluid.

Abstract: In some examples, a device includes a catheter insert elongated body defining a body lumen, the catheter insert elongated body being configured to be at least partially inserted to a catheter lumen defined by a catheter without covering a first fluid opening of the catheter and to form a fluidically tight coupling with the catheter, and one or more sensors positioned on the elongated body. At least one of the one or more sensors are configured to sense a substance of interest. The catheter insert elongated body includes a material that is a substantially non-permeable to the substance of interest.