Patents by Inventor David J. Waterhouse

David J. Waterhouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
    Patent number: 7928096
    Abstract: The present invention provides compound of the formula (I): in which at least two of R1, R2, R3, R4, R5, and R6 are N2O2M and related compounds, substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: April 19, 2011
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: David J. Waterhouse, Preeya Kapur, Larry K. Keefer, Joseph A. Hrabie, Frank De Rosa
  • Methods for separation and detection of ketosteroids and other carbonyl-containing compounds
    Patent number: 7807472
    Abstract: Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: October 5, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xia Xu, Regina G. Ziegler, David J. Waterhouse, Joseph E. Saavedra, Larry K. Keefer
  • POLYDIAZENIUMDIOLATED CYCLIC POLYAMINES WITH POLYPHASIC NITRIC OXIDE RELEASE AND RELATED COMPOUNDS, COMPOSITIONS COMPRISING SAME AND METHODS OF USING SAME
    Publication number: 20090068248
    Abstract: The present invention provides compound of the formula (I): in which at least two of R1, R2, R3, R4, R5, and R6 are N2O2M and related compounds, substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.
    Type: Application
    Filed: November 11, 2008
    Publication date: March 12, 2009
    Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HE
    Inventors: David J. Waterhouse, Preeya Kapur, Larry K. Keefer, Joseph A. Hrabie, Frank De Rosa
  • Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
    Patent number: 7468435
    Abstract: The present invention provides compound of the formula (I): in which at least two of R1, R2, R3, R4, R5, and R6 are N2O2M and related compounds substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: December 23, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David J. Waterhouse, Preeya Kapur, Larry K. Keefer, Joseph A. Hrabie, Frank De Rosa