Abstract: A method of phonophoretic transfer of an active agent into or across a porous surface, which method comprises contacting the active agent with the porous surface and applying thereto ultrasound at a frequency of between 20 kHz and 3 MHz; characterised in that the active agent is ideally cationic and is disposed in a low viscosity carrier and wherein the active agent is in direct contact with the porous surface. An apparatus for phonophoretic transfer of an active agent to or through a porous surface, said apparatus comprising an ultrasonic generator, a housing provided with an ultrasound transducer mounted in or on housing, and a treatment chamber disposed in or on said housing, said transducer being directed towards said treatment chamber, wherein the treatment chamber is provided with a liquid-tight membrane to retain the active agent against a porous surface located in the treatment chamber during sonication.

Abstract: The invention here described relates to monitoring the effect of angiogenesis inhibiting drugs used to treat cancer in breast and testicular tissues. A probe combining electromagnetic radiation in the red and infra-red part of the spectrum is physically combined with a series of Ultrasound Doppler transducers arranged to monitor blood flow over one hemisphere of the tumour. This arrangement overcomes the major difficulty with conventional Doppler blood flow probes that the signals vary more from area to area of the cancer than the changes induced by the drugs acting on the neovascularisation over short time intervals. The invention envisages using probes with transducers of different frequencies and where the piezoelements are angled to cover such an area of angiogenesis that inhomogeneities become insignificant, by virtue of the fact that signals from all the vessels in a hemispherical volume of the tumour's advancing front are collected and processed electronically to produce the observed spectra.

Abstract: An apparatus for the examination of living tissues, comprises an illuminator (228) for illuminating the tissue with infra-red-containing electromagnetic radiation, a television camera (202) for receiving the radiation which is transmitted through the tissue and image devices (216) for producing an image of the received radiation. In addition a probe (224) is provided for applying ultrasound to a region of the tissue and for receiving the reflected ultrasonic signals from the region. The signals obtained are representative of the velocity of blood flow in the region and a computer (216) is provided for generating from the signal an image which provides an indication of blood flow velocity in the region. The apparatus further comprises an arm rotatably mounted on a support about a pivot, the television camera (202) being mounted on the arm on one side of the pivot. A device for holding the tissue to be imaged by the television camera is mounted on the arm on the other side of the pivot.

Abstract: The invention provides a thermocouple device comprising a base wire 1 and a plurality of junctions 3 spaced along said wire, each of said junctions being connected to a monitoring means which provides a visual indication of the temperature at each junction 3. A heating coil 2 or energy absorbative material may be disposed along the length of the base wire 1 to assist in detection of liquid flow, ultrasonic flux or bubble presence.

Abstract: Apparatus for removing biological material from a body thereof comprising a hollow tubular elongate member, one end of which can engage biological material to be removed, a casing in which a portion of the tubular member is mounted for longitudinal sliding movement, a motor which is connected to the casting and has a rotatable drive shaft, means for coupling the rotation of the drive shaft to the tubular member so as longitudinally to vibrate the tubular member and means for withdrawing removed biological material up the tubular member from the said end thereof.

Abstract: An ultrasound unit for the clinical application of hyperthermia to tumor cells in soft tissue. The ultrasound hyperthermic unit includes in one aspect an array of sonic transducers (1) radially disposed about an axis and angled to direct sonic energy (12) towards said axis at a point remote from said array, each transducer being adapted for angular movement relative to the other transducers thereby to allow adjustment of the shape of the acoustic focus. The array is computer controlled both with regard to acoustic focus and with regard to the energy imparted by each member of the array, said control being mediated by temperatures sensing means (40) adjacent a tumor. This ultrasound unit may be associated with a heat treatment tank (51, 31) including a flexible membrane (32, 52) which may overlie a tumor, thereby to locally raise the temperature and reduce the amount of ultrasonic power required to achieve a desired temperature.

Abstract: A tele-diaphanography apparatus suitable for transilluminating human or animal tissues, which apparatus comprises a first housing including a source of light of wavelength from 300 Nm to 2000 Nm; means for directing light from the first light source onto the tissues to be examined by transillumination, and a heat-absorbing filter located in the path of the light from the light source; a second housing including a source of light of wavelength from 300 Nm to 2000 Nm, and means for directing the light from the second light source onto the tissues to be examined; a light detector for detecting the light transmitted through the transilluminated tissue being examined; a visual display unit for displaying the image detected by the light detector; and recording means for recording the image detected by the light detector.