Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: Methods and systems are provided for treating a contaminated environmental medium. In one example, the treatment includes adding a first jarosite-group mineral to the contaminated environmental medium to form a wet mixture under a set of conditions. The set of conditions is maintained over a duration of time to expedite precipitation of a second jarosite-group mineral, the second jarosite-group mineral incorporating contaminant cations and contaminant anions into a structure of the second jarosite-group mineral. The first jarosite-group mineral is added in situ at a contamination site.

Abstract: Methods and systems are provided for treating a contaminated environmental medium. In one example, the treatment includes adding a salt to the contaminated environmental medium to form a slurry. The slurry is heated to irreversibly precipitate a jarosite-group mineral incorporating contaminant cations and contaminant anions into its structure.

Abstract: Methods and systems are provided for treating a contaminated environmental medium. In one example, the treatment includes adding a salt to the contaminated environmental medium to form a slurry. The slurry is heated to irreversibly precipitate a jarosite-group mineral incorporating contaminant cations and contaminant anions into its structure.

Abstract: The invention relates to the reinforcement of materials by the dispersal of structures in the material to be reinforced. In particular the invention relates to the reinforcement of materials and involves the random dispersal of independent three-dimensional structures in the material, these structures may be a mixture of left and right handed structures and/or comprise a series of lumen to anchor them into the material and/or be selected from a subset of possible three dimensional structures based on the number of apices and connections between these.

Abstract: A side curtain air bag assembly for use in protection of an occupant within a vehicle which has a roof and a side structure below the roof. The assembly includes an inflatable air bag curtain adapted for inflation away from the vehicle roof in covering relation to at least a portion of the side structure between the side structure and an occupant. The assembly further includes a directional guide assembly including a dynamic guide element operatively connected to the inflatable air bag curtain such that upon inflation of the inflatable air bag curtain away from the vehicle roof, the dynamic guide element is carried in a direction extending away from the vehicle roof. Upon application of a tensioning force between the inflatable air bag curtain and the dynamic guide element having a vertical force component projecting towards the vehicle roof and a horizontal force component projecting into the inflatable air bag curtain the dynamic guide element is substantially locked into place at a position below the roof.

Abstract: A side curtain air bag assembly for use in protection of an occupant within a vehicle which has a roof and a side structure below the roof. The assembly includes an inflatable air bag curtain adapted for inflation away from the vehicle roof in covering relation to at least a portion of the side structure between the side structure and an occupant. The assembly further includes a directional guide assembly including a dynamic guide element operatively connected to the inflatable air bag curtain such that upon inflation of the inflatable air bag curtain away from the vehicle roof, the dynamic guide element is carried in a direction extending away from the vehicle roof. Upon application of a tensioning force between the inflatable air bag curtain and the dynamic guide element having a vertical force component projecting towards the vehicle roof and a horizontal force component projecting into the inflatable air bag curtain the dynamic guide element is substantially locked into place at a position below the roof.

Abstract: A containment structure for housing an inflatable air bag cushion and inflator. Extrusion processes are used to form the portion of the containment structure which houses the inflatable air bag cushion while non-extrusion processes are used to form the portion of the containment structure which houses the inflator in fluid communication with the inflatable cushion. The portion of the containment structure which houses the inflatable air bag cushion is preferably formed from a lightweight, readily deformable material and will preferably be formed from extruded aluminum or plastic. The portion of the containment structure housing the inflator is preferably formed by a deep drawing or molding process so as to include an integral chamber sized for the acceptance and storage of the inflator therein.

Abstract: A containment structure for housing an inflatable air bag cushion and inflator. Extrusion processes are used to form the portion of the containment structure which houses the inflatable air bag cushion while non-extrusion processes are used to form the portion of the containment structure which houses the inflator in fluid communication with the inflatable cushion. The portion of the containment structure which houses the inflatable air bag cushion is preferably formed from a lightweight, readily deformable material and will preferably be formed from extruded aluminum or plastic. The portion of the containment structure housing the inflator is preferably formed by a deep drawing or molding process so as to include an integral chamber sized for the acceptance and storage of the inflator therein.

Abstract: An air bag module includes an axially elongated, extruded housing having a nautilus-shaped profile defined by a single continuously extending spiral-shaped wall. The spiral-shaped wall has first and second free ends and the spiral-shaped wall has a generally continually increasing radius of curvature from the first end to the second end. The housing preferably has a decreased radius portion for holding an inflator therein and an increased radius portion for holding an air bag therein. The decreased radius portion has a radius of curvature which is less than a radius of curvature of the increased radius portion.