Abstract: An aircraft includes a machine body that encloses a turbofan gas turbine engine and a plurality of ancillary systems. The turbofan gas turbine engine includes, in axial flow sequence, a first heat exchanger module, a fan assembly, a compressor module, a combustor module, a turbine module, and an exhaust module. The aircraft includes a second heat exchanger module. The machine body comprises a single fluid inlet aperture, with the fluid inlet aperture being configured to allow a fluid cooling flow to enter the machine body and to pass through the first heat exchanger module. When a temperature of the fluid cooling flow is less than a temperature of a fluid to be cooled, the fluid to be cooled is directed to the first heat exchanger module, and when a temperature of the fluid cooling flow is greater than a temperature of the fluid to be cooled, the fluid to be cooled is directed to the second heat exchanger module and cooled using a fuel supply for the gas turbine engine.

Abstract: Nucleic acid aptamers having a high binding affinity and specificity for malodorous molecules and the use of such aptamers to reduce the intensity of the undesirable smells in personal care compositions.

Abstract: Provided herein are compounds identified as inhibitors of KRAS protein activity that can be used to treat various diseases and disorders, such as cancer.

Abstract: In accordance with an embodiment, described herein is a system and method for delivery of content based on matching of user profiles with content metadata. The system enables delivery of personalized content, without the overhead of managing segment targeting rules, while providing content publishers or marketers with complete control over such personalization. A recommendation service or application program interface, provided by a computer, cloud computing environment, or other type of computer system, enables receipt and processing of requests, from client devices, for personalized content. A recommendation engine delivers content assets in response to a request from a client device. The recommendation engine determines a content channel and a user identity associated with the request, and then delivers content assets based on rules governing the matching of content asset metadata with the user profile. While content classification evolves over time, so also does the personalization of delivered content.

Abstract: A method for identifying documents that are similar in content to an input document includes receiving a request for identifying similar documents from among a plurality of candidate documents, retrieving document classification attributes for the input document and the candidate documents, where the document classification attributes are document level attributes.

Abstract: A fuel pump assembly comprises a plunger arranged to reciprocate within a plunger bore via a drive shaft, to perform a pumping cycle comprising a pumping stroke and a return stroke, the pumping stroke comprising movement of the plunger from a bottom dead centre (BDC) position to a top dead centre (TDC) position, and the return stroke comprising movement of the plunger from the TDC position to the BDC position. The fuel pump assembly comprises a spring assembly including a return spring that is cooperable, at a first end, with a first member coupled to the plunger and movable at a first speed dependent on the speed of rotation of the drive shaft and, at a second end, with a second member which is movable at a damped speed relative to the first speed.

Abstract: A software development infrastructure can enable user developers to select remote hardware devices to develop and test their software programs. For some tests and development activity, physical access to the remote device can be provided by the infrastructure administrator by replacing the internal calls of an application with mimic code, which can respond to application requests for sensor data, as if the user was physically handling the remote device at the same location.

Abstract: The present invention provides methods for predicting whether or not a test subject having primary biliary cholangitis (PBC) will benefit from advanced treatment in the form of a second-line agent used in addition to, or as an alternative to, ursodeoxycholic acid (UDCA). Associated methods for determining the therapeutic effect of a treatment regimen for PBC, methods for monitoring PBC progression, methods of PBC treatment, kits and assay devices are also provided.

Abstract: A turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly comprises a plurality of fan blades defining a fan diameter (D). The heat exchanger module comprises a plurality of heat transfer elements. The heat exchanger module is in fluid communication with the fan assembly by an inlet duct. The inlet duct has a fluid path length along a central axis of the inlet duct between a downstream-most face of the heat transfer elements and an upstream-most face of the fan assembly. The fluid path length is less than 10.0*D.

Abstract: An aerosol delivery device includes a first aerosol generator to generate a first aerosol from a first aerosol precursor and to introduce the first aerosol into a first fluid flow pathway, and a second aerosol generator to generate a second aerosol from a second aerosol precursor and to introduce the second aerosol into a second fluid flow pathway. The first aerosol is sized for pulmonary penetration. The second aerosol generator comprises a Venturi aperture to dispense and aerosolise the second aerosol precursor in the second aerosol generator. The second aerosol precursor is a liquid, and the second aerosol is sized to inhibit pulmonary penetration. The second aerosol is transmissible within a mammalian oral and/or nasal cavity. The second aerosol includes an active component for activating at least one of: one or more taste receptors in the oral cavity and one or more olfactory receptors in the nasal cavity.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly includes a plurality of fan blades defining a fan diameter, and the heat exchanger module is in fluid communication with the fan assembly by an inlet duct. The heat exchanger module includes a plurality of heat transfer elements for transfer of heat from a first fluid contained within the heat transfer elements to an airflow passing over a surface of the heat transfer elements prior to entry of the airflow into an inlet to the fan assembly. At full-power condition, the engine produces a maximum thrust T (N), the heat exchanger module transfers a maximum heat rejection H (W) from the first fluid to the airflow, and a Heat Exchanger Performance parameter PEX (W/N) defined as PEX=H/T is 0.4 to 6.0.

Abstract: Technologies for detecting changes in a namespace using namespace enumeration endpoint response payloads are disclosed. A namespace is enumerated at a first time by retrieving response payloads containing metadata describing each location in the namespace from a namespace enumeration endpoint. Signatures are generated based on the response payloads and stored. To determine if changes were made to the namespace between the first time and a subsequent second time, metadata is retrieved from the namespace enumeration endpoint for the namespace at the second time and signatures are generated. Signatures generated at the first time are then compared to the signatures generated at the second time. If the signatures are different, the items in the location in the namespace changed between the first time and the second time. Changes occurring in a location of the namespace can then be identified based on the metadata obtained at the first and second times.

Abstract: There is provided a fuel management system for a gas turbine engine.

Abstract: This disclosure is directed to allocation of one or more radio bands to a user equipment (UE) for establishing a radio link with a radio node (e.g., eNodeB or gNodeB). The radio bands may include a shared band, such as citizens band radio service (CBRS), a primary licensed band, such as the B66 band, and/or an unlicensed band, such as B46 band. A radio communications system may consider a variety of parameters associated with the distance of a UE from a radio node, signal strength of a signal from the UE, the services requested by the UE, and/or spectral availability of the each of the radio bands to determine which radio band(s) to allocate to the UE. In some cases, the radio band allocated to a UE may be dynamically changed by the radio communications system as conditions related to the UE and/or the mobile network change.

Abstract: An example of a flow cell includes a substrate having depressions separated by interstitial regions. First and second primers are immobilized within the depressions. First transposome complexes are immobilized within the depressions, and the first transposome complexes include a first amplification domain. Second transposome complexes are also immobilized within the depressions, and the second transposome complexes include a second amplification domain. Some of the first transposome complexes, or some of the second transposome complexes, or some of both of the first and second transposome complexes include a modification to reduce tagmentation efficiency.

Abstract: Embodiments of the present invention provide techniques, systems, and methods for remote, agent-less enterprise computer threat data collection, malicious threat analysis, and identification and reporting of potential and real threats present on an enterprise computer system. Specifically, embodiments are directed to a system that securely identifies and maps sensitive information from computers across the enterprise. Secure and sensitive information may be internally encrypted and analyzed for indicators of compromise, threatening behavior, and known vulnerabilities. The remote, agent-less collection, analysis, and identification process can be repeated periodically to detect and map additional sensitive information over time, and may delete itself after completion to avoid detection.

Abstract: A wireless backhaul link is established via a low-band frequency division duplex (FDD) carrier between an integrated access and backhaul (IAB) node and an IAB donor node or between the IAB node and another IAB node that is linked to the IAB donor node, in which the IAB donor node provides a backhaul connection to a core network of a wireless carrier network. Further, one or more corresponding wireless backhaul links are established between the IAB node and one or more additional IAB nodes via one or more corresponding low-band FDD carriers. When a user device is determined to be in range of the IAB node for an establishment of a wireless access link via a mid-band FDD carrier or a time division duplex (TDD) carrier, the wireless access link is established between the IAB node and the user device via the mid-band FDD carrier or the TDD carrier.

Abstract: Systems, methods, and devices can be utilized to aggregate downlink millimeter wave (mmWave) frequency resources based on various conditions. In an example method, a connection request for downlink data is received from a user equipment (UE). The example method includes determining that a first congestion level of a first mmWave downlink channel is below a first threshold and determining that a second congestion level of a second mmWave downlink channel is below a second threshold. An activation request is transmitted to the UE. The activation request instructs the UE to activate a first antenna corresponding to the first mmWave downlink channel and to activate a second antenna corresponding to the second mmWave downlink channel. At least a portion of the downlink data is transmitted to the UE over the first mmWave downlink channel and the second mmWave downlink channel.

Abstract: A recyclable packaging film comprising a coextruded web having a high degree of optical clarity and a high level of moisture barrier. The coextruded web comprises a skin layer comprising polyethylene having a high degree of optical clarity and a heat sealant layer which forms an innermost layer of the packaging film, the heat sealant layer comprising a polyolefin polymer. The coextruded web also includes a moisture barrier layer which is disposed intermediate the skin layer and the heat sealant layer. An energy-cured coating is disposed on the skin layer of the coextruded web, wherein the energy-cured coating has a coating weight which is effective to impart a property in the packaging film selected from reduced susceptibility to melting, reduced susceptibility to stretching, or both.

Abstract: The present invention provides compositions and methods for immunotherapy, which include shelf-stable pharmaceutical compositions for inducing antigen-specific T cells. Such compositions are employed as components of an artificial antigen presenting cell (aAPC), to provide a patient with complexes for presentation of an antigen (e.g., a tumor antigen) and/or a T cell co-stimulatory molecule.