Abstract: Described are methods of inhibiting one or more pharmaceutical agent from binding to a plasma protein so it binds to its target. Specifically, a plasma protein binding agent is administered prior to, concurrently with, or after the administration of one or more pharmaceutical agents that binds to a plasma protein in vivo. The methods of the present invention allow pharmaceutical agents that bind to plasma binding proteins to treat disease cells in vivo.

Abstract: A limited slip differential for vehicular applications that eliminates chattering noise from the differential while maintaining seal integrity. This is accomplished by the use of a differential casing that includes at least a pair of fluid seals isolating a first chamber for bathing the respective differential components in a fluid lubricant appropriate to the contained components. A fluid lubricant, such as one containing a friction modifier is particularly suitable for the array of friction plates and pads of a disk pack, but can be detrimental to sealing elements, such as about the pinion gear. The separate chambers allows for the use of different fluid lubricants.

Abstract: In a differential/mechanism for transmitting power from a drive shaft to the axle shafts of a motor vehicle, an axle shaft end play adjuster is threadingly disposed at the end of the axle shaft adjacent the differential pinion shaft. The end play adjuster limits the range of axially inward movement of the axle shaft. A axle shaft end play adjuster assembly includes a shaft supported for rotation about a longitudinal axis having a threaded portion located near an axial end of the shaft to support a washer and a threader adjustment member threadingly engaging the end of the axle shaft adjacent the differential pinion shaft. The adjustment members threaded onto the interior axial end of the axle shaft may respectively engage the associated side gear through a splined interface.

Abstract: The device for adjusting an endplay of an axle shaft in a differential assembly includes an axle shaft supported in a differential case for rotation about a longitudinal axis, and an endplay adjustment member threadedly mounted on a terminal shoulder provided at an inboard end of the axle shaft. The axle shaft has external splines adapted to mate with internal splines of a differential side gear and an annular groove located adjacent to the terminal shoulder. The annular groove receives a retainer ring provided to limit an axial displacement of the axle shaft in an outboard direction. The endplay adjustment member is selectively positionable on the terminal shoulder along the axial direction of the axle shaft to variably limit an axial movement of the retainer ring within the annular groove, thus adjusting the axle shaft endplay.

Abstract: A differential assembly having a limited slip device with a mechanism to adjust the preload of a clutch pack. The differential assembly includes a differential case with pinion and side gears disposed therein. The clutch pack is disposed between at least one of the side gears and the differential case to retard relative rotation there between. An adjustment collar is disposed between the clutch pack and the differential case to adjust the preload of the clutch pack. Elongated slots are formed through the differential case to provide external access to spanner slots formed in the adjustment collar. A tool may be inserted through the elongated slots to engage the spanner slots and selectively rotate the adjustment collar to adjust the preload.