Patents by Inventor David Karli

David Karli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11340212
    Abstract: Methods of analyzing a biological fluid to determine an expected therapeutic benefit of the fluid include determining amounts of components within the biological fluid. Comparisons of a first component of the biological fluid relative to another component of the biological are made to characterize a therapeutic effect of the biological fluid.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: May 24, 2022
    Assignee: Greyledge Technologies, LLC
    Inventors: David Karli, Theodore Sand
  • Publication number: 20180306773
    Abstract: Methods of analyzing a biological fluid to determine an expected therapeutic benefit of the fluid include determining amounts of components within the biological fluid. Comparisons of a first component of the biological fluid relative to another component of the biological are made to characterize a therapeutic effect of the biological fluid.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 25, 2018
    Inventors: David Karli, Theodore Sand
  • Publication number: 20180100133
    Abstract: An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve, a second valve, and a concentration and flow logic and control component. The concentration and flow logic and control component is configured to: determine a first volume of a target cell-poor fraction in the first vessel to mix with a target cell-rich fraction in the second vessel in order to form a target cell-rich concentrate having a concentration of target cells that is within a target concentration range; and control the second valve to transfer the first volume of the target cell-rich fraction from the first vessel to the second vessel to form the target cell-rich concentrate. The target concentration range is between 1.0 and 1.5×106 target platelets/?L.
    Type: Application
    Filed: December 10, 2017
    Publication date: April 12, 2018
    Inventors: David Karli, Theodore Sand
  • Patent number: 9840690
    Abstract: An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve, a second valve, and a concentration and flow logic and control component. The concentration and flow logic and control component is configured to: determine a first volume of a target cell-poor fraction in the first vessel to mix with a target cell-rich fraction in the second vessel in order to form a target cell-rich concentrate having a concentration of target cells that is within a target concentration range; and control the second valve to transfer the first volume of the target cell-rich fraction from the first vessel to the second vessel to form the target cell-rich concentrate. The target concentration range is between 1.0 and 1.5×106 target cells/?L.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: December 12, 2017
    Assignee: Greyledge Technologies, LLC
    Inventors: David Karli, David L. Bombard
  • Publication number: 20150376564
    Abstract: An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve, a second valve, and a concentration and flow logic and control component. The concentration and flow logic and control component is configured to: determine a first volume of a target cell-poor fraction in the first vessel to mix with a target cell-rich fraction in the second vessel in order to form a target cell-rich concentrate having a concentration of target cells that is within a target concentration range; and control the second valve to transfer the first volume of the target cell-rich fraction from the first vessel to the second vessel to form the target cell-rich concentrate. The target concentration range is between 1.0 and 1.5×106 target cells/?L.
    Type: Application
    Filed: September 8, 2015
    Publication date: December 31, 2015
    Inventors: David Karli, David L. Bombard
  • Patent number: 9164079
    Abstract: This disclosure describes systems, methods, and apparatuses for forming concentrates of platelet-rich plasma or bone marrow cells having user-defined concentrations, concentration ranges, and/or volumes. Whole blood or bone marrow samples can be passed through one or two separation operations in which platelets or bone marrow cells are separated from red blood cells and concentrated in a plasma. During this separation and concentrating, a total number of platelets or bone marrow cells or a concentration of either is determined and then used to ascertain what volumes and concentrations need be mixed in order to produce a platelet-rich plasma concentrate or a bone marrow-rich plasma concentrate having a target concentration and/or volume.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: October 20, 2015
    Assignee: GREYLEDGE TECHNOLOGIES LLC
    Inventors: David Karli, David L. Bombard
  • Publication number: 20120237490
    Abstract: This disclosure describes systems, methods, and apparatus for forming concentrates of platelet-rich plasma or bone marrow cells having user-defined concentrations, concentration ranges, and/or volumes. Whole blood or bone marrow samples can be passed through one or two separation operations in which platelets or bone marrow cells are separated from red blood cells and concentrated in a plasma. During this separation and concentrating, a total number of platelets or bone marrow cells or a concentration of either is determined and then used to ascertain what volumes and concentrations need be mixed in order to produce a platelet-rich plasma concentrate or a bone marrow-rich plasma concentrate having a target concentration and/or volume.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 20, 2012
    Applicant: GREYLEDGE TECHNOLOGIES, LLC
    Inventors: David Karli, David L. Bombard