Abstract: Provided are methods of sensitizing LKB1/STK11 deficient cancers to immune therapy. A method for treatment for LKB1/STK11 deficient cancers is provided comprising administration of inhibitor or inhibitors of one or more of NAMPT, CD38, SHP2, CXCR1/2, HDAC4 and PARP in combination with immunotherapy.

Abstract: A non-viral vector, comprising, from 5? to 3?, flanked by two transposon terminal inverted repeats, an inducible promoter, a first coding region comprising a specific combination of genes whose expression is localized to a tumor microenviorment and their function being mediators of CAR persistence and anti-tumor mechanisms to stimulate or enhance a patient anti-tumor response; a second promoter and coding region for expressing one or more artificial immunosurveillance chimeric antigen receptors (AI-CAR), and a truncated CD20 or truncated EGFR safety target. A polycistronic mRNA comprised of a specific combination of transiently expressed anti-tumor mechanisms designed to stimulate a patient anti-tumor response the same as an AI-CAR vector.

Abstract: An electrostatically steerable actuator includes a gimbaled platform. A central portion of a rear side of the platform extends outward from the platform. A diameter of the central portion is substantially smaller than a corresponding diameter of the platform. An array of electrodes faces the rear side of the platform to provide an adjustable electrostatic field for tilting the platform.

Abstract: Embodiments of the present invention are directed to a system and method for indoor wireless optical communication. The system may include a central unit and a plurality of user units. A bi-directional optical communication link may be established over a collimated invisible light beam to enable transmission of wireless communications between a remote communication device and a user unit. The central and user units include an optical transmitter. At least one of the user unit and the central unit comprises a visible light source configured to produce a collimated visible light beam to enable alignment of the user unit and the central unit upon establishment of the bi-directional optical communication link.

Abstract: An electrostatically steerable actuator includes a gimbaled platform. A central portion of a rear side of the platform extends outward from the platform. A diameter of the central portion is substantially smaller than a corresponding diameter of the platform. An array of electrodes faces the rear side of the platform to provide an adjustable electrostatic field for tilting the platform.

Abstract: Embodiments of the present invention are directed to a system and method for indoor wireless optical communication. The system may include a central unit and a plurality of user units. A bi-directional optical communication link may be established over a collimated invisible light beam to enable transmission of wireless communications between a remote communication device and a user unit. The central and user units include an optical transmitter. At least one of the user unit and the central unit comprises a visible light source configured to produce a collimated visible light beam to enable alignment of the user unit and the central unit upon establishment of the bi-directional optical communication link.

Abstract: A MEMS variable optical attenuator (VOA) comprises at least one semitransparent refraction-mode shutter having a wedge shape and operative to attenuate an optical beam transmitted from a first optical fiber to a second optical fiber using refraction of the beam, and an actuator operative to position the shutter in the path of the beam. Optionally, the VOA further comprises a locking mechanism for locking the shutter after actuation, and at least one damper connected to the shutter for shortening the VOA switching time. The actuator may include in various embodiments a folding suspension with straight or curved springs, some springs interacting electrostatically with one or more side electrodes to provide an essentially linear dependence of shutter movement on actuation voltage.