Abstract: Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses.

Abstract: The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell polyomavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma.

Abstract: Herpes Simplex Virus type 2 (HSV-2) epitopes bound by CD8 or CD4 tissue resident memory cells at a healed site of HSV-2 infection are disclosed. The HSV-2 epitopes can be used as immunogenic compositions to elicit protective immune responses against HSV-2.

Abstract: Methods and systems are described for simplifying a causal influence model that describes influence of parent nodes Xi (i=1, . . . , n) on possible states of the child node Y. The child node Y and each one of the parent nodes Xi (i=1, . . . , n) are assumed to be either a discrete Boolean node having states true and false, a discrete Ordinal node having a plurality of ordered states; and a Categorical node having a plurality of unordered states. The influence of each parent node Xi on the child node Y is assumed to be a promoting influence and an inhibiting influence. User interfaces are described that incorporate these specific node types.

Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.

Abstract: An apparatus for making probabilistic inferences based on a belief network includes a processing system configured to receive as input one or more parameters of a causal influence model. The belief network has a child node Y and one or more parent nodes Xi (i=1, . . . , n) for the child node Y. The causal influence model describes the influence of the parent nodes Xi on possible states of the child node Y. The processing system is further configured to use a creation function to convert the parameters of the causal influence model into one or more entries of a conditional probability table. The conditional probability table provides a probability distribution for all the possible states of the child node Y, for each combination of possible states of the parent nodes Xi.

Abstract: Methods and systems are described for simplifying a causal influence model that describes influence of parent nodes Xi (i=1, . . . , n) on possible states of the child node Y. The child node Y and each one of the parent nodes Xi (i=1, . . . , n) are assumed to be either a discrete Boolean node having states true and false, a discrete Ordinal node having a plurality of ordered states; and a Categorical node having a plurality of unordered states. The influence of each parent node Xi on the child node Y is assumed to be a promoting influence and an inhibiting influence. User interfaces are described that incorporate these specific node types.

Abstract: Methods and systems are described for simplifying a causal influence model that describes influence of parent nodes Xi (i=1, . . . , n) on possible states of the child node Y. The child node Y and each one of the parent nodes Xi (i=1, . . . , n) are assumed to be either a discrete Boolean node having states true and false, a discrete Ordinal node having a plurality of ordered states; and a Categorical node having a plurality of unordered states. The influence of each parent node Xi on the child node Y is assumed to be a promoting influence and an inhibiting influence. User interfaces are described that incorporate these specific node types.

Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.

Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.

Abstract: Methods and systems are described for simplifying a causal influence model that describes influence of parent nodes Xi (i=1, . . . , n) on possible states of the child node Y. The child node Y and each one of the parent nodes Xi (i=1, . . . , n) are assumed to be either a discrete Boolean node having states true and false, a discrete Ordinal node having a plurality of ordered states; and a Categorical node having a plurality of unordered states. The influence of each parent node Xi on the child node Y is assumed to be a promoting influence and an inhibiting influence. User interfaces are described that incorporate these specific node types.

Abstract: An apparatus for making probabilistic inferences based on a belief network includes a processing system configured to receive as input one or more parameters of a causal influence model. The belief network has a child node Y and one or more parent nodes Xi (i=1, . . . , n) for the child node Y. The causal influence model describes the influence of the parent nodes Xi on possible states of the child node Y. The processing system is further configured to use a creation function to convert the parameters of the causal influence model into one or more entries of a conditional probability table. The conditional probability table provides a probability distribution for all the possible states of the child node Y, for each combination of possible states of the parent nodes Xi.

Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.