Abstract: An assembly includes a first tube including a first flange at one end, wherein the first flange includes a first knife-edge ring defined in an axial face thereof. A second tube includes a second flange at one end, wherein the second flange includes a second knife-edge ring defined in an axial face thereof. A gasket is seated between the first and second flanges. The gasket is in a deformed state conforming to the first and second knife-edge rings to seal a space inside the first and second tubes from an external environment. A nut is included radially outward from the first and second flanges, wherein the nut includes internal threads engaged to compress the first and second flanges toward one another.

Abstract: Provided herein are oligonucleotide compositions that inhibit ANGPTL7 and reduce intraocular pressure when administered to an eye. The oligonucleotide compositions contain nucleoside modifications.

Abstract: Provided nucleic acid-based expression construct for the target cell-specific production of a therapeutic protein, such as a pro-apoptotic protein, within a target cell, including a target cell that is associated with aging, disease, or other condition, in particular a target cell that is a senescent cell or a cancer cell.

Abstract: There is a need for more effective and efficient constrained-optimization-based operational load balancing. In one example, a method comprises determining constraint-satisfying operator-unit mapping arrangements that satisfy an operator unity constraint and an operator capacity constraint; for each constraint-satisfying operator-unit mapping arrangement, determining an arrangement utility measure; processing each arrangement utility measure using an optimization-based ensemble machine learning model that is configured to determine an optimal operator-unit mapping arrangement of the plurality of constraint-satisfying operator-unit mapping arrangements; and initiating the performance of one or more operational load balancing operations based on the optimal operator-unit mapping arrangement.

Abstract: An automated greeting card conveyance system is disclosed that includes a first conveyor configured to transport pre-decorated greeting cards along a first conveyance path and a second conveyor configured to transport envelopes along a second conveyance path. A control system controls customization of each greeting card and envelope by (a) determining a card identifier of the greeting card, (b) identifying customized content associated with an order for the greeting card having the card identifier, and (c) causing the customized content to be printed on the greeting card and envelope. A coupling system may also be used to automatically insert the greeting card into the envelope. In addition, a sealing system may be used to automatically seal envelope having a pointed envelope flap.

Abstract: In an embodiment, a computer-implemented method of tracking soil sampling in a field is disclosed. The method comprises receiving, by a processor, digitally stored field map data and digitally stored sampling data. The method further comprises displaying, by the processor, a field map depicting the first set of sampling points in a computer-generated graphical user interface. In addition, the method comprises receiving a selection of a first sampling point and displaying first sampling data associated with the first sampling point. The method also comprises receiving an update indicating that a soil sample has been collected at the first sampling point. Finally, the method comprises determining a second sampling point at which a next soil sample is to be collected and displaying the second sampling point in the field map.

Abstract: A system and method are disclosed for the collection and aggregation of genomic, medical, and other data of interest for individuals and populations that may be of interest for analysis, research, pharmaceutical development, medical treatment, and so forth. Contributors become members of a community upon creation of an account and providing of data or files. The data is received and processed, such as to analyze, structure, perform quality control, and curate the data. Value or shares in one or more community databases are computed and attributed to each contributing member. The data is controlled to avoid identification or personalization. Third parties interested in the database information may contribute value (e.g., pay) for access and use. Value flows back to the members and to a system administrative entity.

Abstract: In an aspect, a toy assembly is provided and includes a housing and an inner object inside the housing. The inner object includes a breakout mechanism that includes a hammer and an actuation lever. The hammer is movable between a retracted position in which the hammer is spaced from the housing and an advanced position in which the hammer is positioned to break the housing. The actuation lever is pivotable from a hammer retraction position towards a hammer driving position so as to drive the hammer towards the advanced position.

Abstract: Disclosed herein are compositions comprising modified oligonucleotides. In some embodiments, the oligonucleotide includes a hydrophobic moiety. In some embodiments, the oligonucleotide includes a vinyl phosphonate. In some embodiments, the oligonucleotide includes modified oligonucleotide sugars such as 2? modified ribose molecules. In some embodiments, the oligonucleotide includes modified internucleoside linkages such as phosphorothioate linkages. In some embodiments, the oligonucleotide includes an siRNA. In some embodiments, the siRNA comprises a duplex region with overhangs on either end.

Abstract: An apparatus includes a soft start manager such as implemented via hardware, software, or a combination of hardware and software. The soft start manager receives input parameter from a power supply; the input parameter (such as output voltage, duty cycle, input voltage, etc.) is associated with conversion of the input voltage into an output voltage that powers a load. The soft start manager monitors a magnitude of the input parameter. Based at least in part on the magnitude of the input parameter, the soft start manager controls a switching period applied to switch circuitry in the power supply.

Abstract: Endless belts, such as for use with e-bikes and other personal mobility systems such as standard bicycles, wheelchairs, scooters including electric scooters, and other systems that utilize a belt for transmitting power to impart motion to the system. The belts are particularly suited for inhibiting “tooth jumping” during use, having a curvature coefficient of no more than 0.01%, and in some embodiments less than 0.005%, with a compressibility coefficient of no more than 0.00075. The belts can utilize reinforcing cords, such as carbon cords, which when incorporated into the final belt, some cords have an open porosity of 10 vol-% or less, in some embodiments 5 vol-% or less.

Abstract: An optimized testing method is used to determine minimum inhibitory concentration (MIC) of a particular antimicrobic for use with a particular microbe. The testing method includes iteratively imaging the microbes mixed with various concentrations of the antimicrobic. The images are thereafter processed to determine one or more of the amount/count of the microbes in each image, the total area occupied by the microbes in each image, and the ratio between the area occupied by the microbes and the count of the microbes. Once a sufficient amount of data is collected, the MIC is determined based on one or more of the count, area, and ratio datasets.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds which are prodrugs of ALOX-15 inhibitors. Also described herein are methods for using such compounds in the treatment of disease.

Abstract: In an aspect, a toy assembly is provided, and includes a housing, an inner object (which may, in some embodiments, be a toy character) inside the housing, a tether, and a breakout motor. The breakout motor is operatively connected to the tether such that operation of the breakout motor drives the tether to rip a hole in the housing to open the housing.

Abstract: In one embodiment, an automated high-speed X-ray inspection system may generate a first X-ray image of an inspected sample at a first direction substantially orthogonal to a plane of the inspected sample. The first X-ray image may be a high-resolution grayscale image. The system may identify one or more elements of interest of the inspected sample based on the first X-ray image. The first X-ray image may include interfering elements that interfere with the one or more elements of interest in the first X-ray image. The system may determine one or more first features associated with respective elements of interest based on variations of grayscale values in the first X-ray images. The system may determine whether one or more defects are associated with the respective elements of interest based on the one or more first features associated with the element of interest.

Abstract: A method for use by a mobile device configured to operate in a wireless network for the communication of data messages with a server is described. The method comprises receiving, at a mobile device, an indication that a pending message is available for retrieval from a host service, and communicating directly with the host service to retrieve the pending message from the host service.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds which are prodrugs of ALOX-15 inhibitors. Also described herein are methods for using such compounds in the treatment of disease.

Abstract: In one embodiment, a computing system may access design data of a printed circuit board to be produced by a manufacturing process. The system may determine one or more corrections for the design data of the printed circuit board based on one or more correction rules for correcting one or more parameters associated with the printed circuit board. The system may automatically adjust one or more of the parameters associated with the design data of the printed circuit board based on the one or more corrections. The adjusted parameters may be associated with an impedance of the printed circuit board. The one or more corrections may cause the impendence of the printed circuit board to be independent from layer thickness variations of the printed circuit board to be produced by the manufacturing process.

Abstract: In one embodiment, an X-ray inspection system may nondestructively inspect a printed circuit board to measure a number of dimensions at a number of pre-determined locations of the printed circuit board. The X-ray inspection system may generate a data set for the printed circuit board based on the measured dimensions. The X-ray inspection system may calculate one or more drilling values based on the data set of the printed circuit board. The X-ray inspection system may provide, to a drilling machine, instructions for drilling a number of plated-through vias based on the calculated drilling values for the printed circuit board.

Abstract: There is a need for solutions for more efficient predictive data analysis systems. This need can be addressed, for example, by a system configured to receive temporal inferences for a predictive task, where each temporal inference is associated with a temporal benchmark and the temporal benchmarks include a base temporal benchmark and supplemental temporal benchmarks; generate a cross-temporal prediction for the predictive task by applying one or more cross-temporal probabilistic updates to the base temporal inference, where each cross-temporal probabilistic update is associated with a supplemental temporal benchmark; and display the cross-temporal prediction using a cross-temporal prediction interface.