Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: Embodiments of the disclosed technologies receive first event data associated with a first party application, receive second event data representing a click, in the first party application, on a link to a third party application, receive third event data from the third party application, convert the third event data to a label, map a compressed format of the labeled third event data to the first event data and the second event data to create multi-party attribution data, group multiple instances of the multi-party attribution data into a batch, add noise to the compressed format of the labeled third event data in the batch, and send the noisy batch to a second computing device. A debiasing algorithm can be applied to the noisy batch. The debiased noisy batch can be used to train at least one machine learning model.

Abstract: In some embodiments, an electrode can include a current collector, a composite material in electrical communication with the current collector, and at least one phase configured to adhere the composite material to the current collector. The current collector can include one or more layers of metal, and the composite material can include electrochemically active material. The at least one phase can include a compound of the metal and the electrochemically active material. In some embodiments, a composite material can include electrochemically active material. The composite material can also include at least one phase configured to bind electrochemically active particles of the electrochemically active material together. The at least one phase can include a compound of metal and the electrochemically active material.

Abstract: The present disclosure provides autonomous vehicle systems and methods that include or otherwise leverage a machine-learned yield model. In particular, the machine-learned yield model can be trained or otherwise configured to receive and process feature data descriptive of objects perceived by the autonomous vehicle and/or the surrounding environment and, in response to receipt of the feature data, provide yield decisions for the autonomous vehicle relative to the objects. For example, a yield decision for a first object can describe a yield behavior for the autonomous vehicle relative to the first object (e.g., yield to the first object or do not yield to the first object). Example objects include traffic signals, additional vehicles, or other objects. The motion of the autonomous vehicle can be controlled in accordance with the yield decisions provided by the machine-learned yield model.

Abstract: In one example of the present disclosure, a method for determining false positive and active indications is disclosed. The method may apply anomaly network event data to a machine learning model. The machine learning model is trained with historic and correlated anomaly network event data. The method then determines which one of the anomaly network event data is a false positive indication and which one is an active indication.

Abstract: A low level contact resistance (LLCR) testing apparatus comprises a test board, an interface board, and a patch board. The test board comprises a processor socket. The interface board connects to both the test board and the patch board. The patch board connects to a contact resistance tester. An LLCR system comprising the LLCR testing apparatus and a contact resistance tester can be portable. The test board can accommodate thermal management solutions of varying sizes and types. Different test board designs can accommodate different socket-processor configurations and the different test boards can be easily accommodated by an LLCR testing apparatus due to its modular design.

Abstract: Disclosed is an eye simulator device, wherein same is a medical training aid and includes: an eyepiece having a display configured to project at least one image onto or through a convex shaped front surface of a simulated eyeball of the eyepiece; a support configured to hold the eyepiece; a simulated eyelid pivotally attached to the support; and an actuator assembly having an actuator arm and an electromagnetic (EM) coil in connection with the actuator arm, so as to control a motion of the simulated eyelid, which allows to more realistically mimic the eye, and to more intuitively mimic a motion change of the eye, and it is illustratable to show a change process of the eye by projecting an eye condition, making it easier for a student to understand.

Abstract: Machine learning, artificial intelligence, and other computer-implemented methods are used to identify various semantically important chunks in documents, automatically label them with appropriate datatypes and semantic roles, and use this enhanced information to assist authors and to support downstream processes. Chunk locations, datatypes, and semantic roles can often be automatically determined from what is here called “context”, to wit, the combination of their formatting, structure, and content; those of adjacent or nearby content; overall patterns of occurrence in a document, and similarities of all these things across documents (mainly but not exclusively among documents in the same document set).

Abstract: Techniques are described herein that are capable of dynamically re-allocating computing resources while maintaining network connection(s). Applications of users are run in a computing unit. Computing resources are allocated among the applications based at least in part on dynamic demands of the applications for the computing resources and resource limits associated with the respective customers. In a first example, the computing resources are dynamically re-allocated among the applications, as a result of changing the resource limit of at least one customer, while maintaining at least one network connection between a client device of each customer and at least one respective application. In a second example, the computing resources are dynamically re-allocated among the applications, as a result of changing the resource limit of at least one customer, while maintaining at least one network connection between an interface and a client device of each customer.

Abstract: We disclose the generation and training of Generative Adversarial Networks (GAN) to synthesize clinical images with skin conditions. Synthetic images for a pre-specified skin condition are generated, while being able to vary its size, location and the underlying skin color. We demonstrate that the generated images are of high fidelity using objective GAN evaluation metrics. The synthetic images are not only visually similar to real images, but also embody the respective skin conditions. Additionally, synthetic skin images can be used as a data augmentation technique for training a skin condition classifier, and improve the ability of the classifier to detect rare but malignant conditions.

Abstract: A video conference call control system is provided with an audio mixer to receive an audio speech signal at one or more network devices connected to the video conference call; to generate first and second talker identification values from the audio speech signal; to compare the first and second talker identification values during a timing comparison window to determine if the first and second talker identification values are identical and received simultaneously or substantially contemporaneously; and to selectively mute one or more audio devices at the network device(s) if the first and second talker identification values are identical and received simultaneously or substantially contemporaneously so that microphone input signals to the audio mixer are muted to prevent “playback” echo effects and so that microphone input and audio loudspeaker output signals to the audio mixer are muted to prevent “double join” echo effects.

Abstract: A data storage system includes a plurality of data storage drives, and a system controller coupled to each data storage drive of the plurality of data storage drives. The system controller is configured to store internal drive management data for each data storage drive of the plurality of data storage drives.

Abstract: The disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.

Abstract: The present application is directed towards compounds, pharmaceutically acceptable salts or prodrugs thereof, which are inhibitors of Histone Deacetylase (HDAC) binding or function. The compounds especially may have some selectivity for inhibiting Class IIa versus Class I HDACs. The present application also relates to methods of using the compounds and to uses of the compounds, especially in relation to the prevention of a disease, disorder or condition associated with Class IIa HDAC activity. In one form, the compounds are (ortho-phenyl) phenyl hydroxamates. In another form, the compounds are as provided in Formula (I), wherein R1 is a phenyl or cycloalkenyl which may be optionally substituted.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: Methods, nodes and computer program products control radio channel deployment when using un-licensed carriers in a wireless communication network and control mobility and/or load balancing target selection when using un-licensed carriers. When performed in an access node, unlicensed carrier intrinsic cell channel load is determined in a cell served by the access node based on one or more predetermined channel load indicators and neighbor cell channel load information is obtained, from one or more neighboring access nodes. The neighbor cell channel load information includes unlicensed carrier channel load in respective cells based on the one or more predetermined channel load indicators. At least one channel deployment operation is initiated based on an outcome of one or more comparative operations including the determined unlicensed carrier intrinsic cell channel load and/or the obtained neighbor cell channel load information.

Abstract: Systems and methods for providing a separate interest rate for an individual transaction are disclosed. A system may provide a service associated with a account having an account balance and an associated first interest rate. The system may include a service device having one or more memory devices storing instructions and one or more processors configured to execute the instructions to perform a separate interest rate service process. The process may include providing a separate interest rate service offer to a client device and receiving a separate interest rate selection from the client device. The process may also include determining a selected portion of the account balance corresponding to an amount to which a second interest rate, different from the first interest rate, is to be applied based on the separate interest rate selection.

Abstract: The present disclosure provides compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK) (e.g., Janus kinase 2 (JAK2)) and/or cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 11 (CDK11)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).

Abstract: Systems, methods, and non-transitory computer-readable media can access a plurality of parameter-based encodings providing a structured representation of an environment captured by one or more sensors associated with a plurality of vehicles traveling through the environment. A given parameter-based encoding of the environment identifies one or more agents that were detected by a vehicle within the environment and respective location information for the one or more agents within the environment. The plurality of parameter-based encodings can be clustered into one or more clusters of parameter-based encodings. At least one scenario associated with the environment can be determined based at least in part on the one or more clusters of parameter-based encodings.

Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.