Publication number: 20070088248
Abstract: The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.
Type:
Application
Filed:
September 5, 2006
Publication date:
April 19, 2007
Applicant:
Iomai Corporation
Inventors:
Gregory Glenn, Kyle Doerksen, Larry Ellingsworth, Diane Epperson, David Frerichs, Mervyn Hamer, Aaron Henningsgaard, Matthew Inouye, Adrian James, Jonathan Kaplan, John Lai, Robert Lister, David Lubensky, Peter MacDonald, Sally Madsen, Brian Mason, Christine McElhaney, Lionel Mohri, Anthony Pigliacampo, Gina Romero, Charles Steeves, Christina Villar, Jianmei Yu