Patents by Inventor David M. Lucas
David M. Lucas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11845817Abstract: The present disclosure relates to synthetic polyisoprene elastomeric articles including: one or more cured blend compositions of pre-vulcanized synthetic polyisoprene particles and non-prevulcanized synthetic polyisoprene particles, wherein the pre-vulcanized synthetic polyisoprene particles and the non-prevulcanized synthetic polyisoprene particles are bonded by mono-sulfidic and/or di-sulfidic, and poly-sulfidic crosslinks, wherein the poly-sulfidic crosslinks are present in an amount of 60 to 79 percent of the total amount of crosslinks in the cured blend composition. Methods of making synthetic polyisoprene elastomeric articles such as gloves or condoms is also disclosed.Type: GrantFiled: March 8, 2019Date of Patent: December 19, 2023Assignee: Ansell LimitedInventors: Koralalage Don Sugathananda Amarasekera, David M. Lucas, Angodage Sujith Ruwan Samantha Perera, Dambadeni Arachchige Ruwani Upekshika Lalanthani
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Publication number: 20210115172Abstract: The present disclosure relates to synthetic polyisoprene elastomeric articles including: one or more cured blend compositions of pre-vulcanized synthetic polyisoprene particles and non-prevulcanized synthetic polyisoprene particles, wherein the pre-vulcanized synthetic polyisoprene particles and the non-prevulcanized synthetic polyisoprene particles are bonded by mono-sulfidic and/or di-sulfidic, and poly-sulfidic crosslinks, wherein the poly-sulfidic crosslinks are present in an amount of 60 to 79 percent of the total amount of crosslinks in the cured blend composition. Methods of making synthetic polyisoprene elastomeric articles such as gloves or condoms is also disclosed.Type: ApplicationFiled: March 8, 2019Publication date: April 22, 2021Inventors: Koralalage Don Sugathananda Amarasekera, David M. Lucas, Angodage Sujith Ruwan Samantha Perera, Dambadeni Arachchige Ruwani Upekshika Lalanthani
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Patent number: 10538609Abstract: A synthetic polyisoprene latex emulsion has pre-vulcanization composition and post vulcanization composition. The pre-vulcanization composition comprises soluble sulfur with high S8 ring structure that is catalytically broken by a zinc dithiocarbamate. Surfactants present in the pre-vulcanization composition wets synthetic polyisoprene particles and permeates small sized sulfur and accelerator molecules into the interior of these particles thereby pre-vulcanizing the particles. The degree of pre-vulcanization is verified by isopropanol index test. The latex emulsion has post-vulcanization composition with accelerators that crosslink inter-particle region during post vulcanization cure cycle. The dipped synthetic polyisoprene article is substantially uniformly cured both in the inter-particle and intra-particle regions and reliably exhibits high cross link density, uniform distribution of double bonds in TEM and zinc segregation at the boundaries or original particles by electron microprobe analysis.Type: GrantFiled: June 28, 2017Date of Patent: January 21, 2020Assignee: Lifestyles Healthcare Pte. Ltd.Inventors: David M. Lucas, Sugath Amarasekera, Dave Narasimhan, Adeline Ai Lin Kung
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Publication number: 20170304261Abstract: Disclosed herein are treatment methods, vaccination methods, compositions, co-therapeutic methods, combination therapeutic compositions and kits comprising silvestrol and silvestrol analogs alone or in combination with therapeutic and preventative therapies. Disclosed herein are also methods, compositions and kits that can be used to treat cancer, viral infections, to modulate the immune system or as preventative therapies.Type: ApplicationFiled: December 8, 2016Publication date: October 26, 2017Inventors: Robert A. Baiocchi, John Thomas Patton, David M. Lucas, Douglas Kinghorn, Michael Grever
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Publication number: 20170298159Abstract: A synthetic polyisoprene latex emulsion has pre-vulcanization composition and post vulcanization composition. The pre-vulcanization composition comprises soluble sulfur with high S8 ring structure that is catalytically broken by a zinc dithiocarbamate. Surfactants present in the pre-vulcanization composition wets synthetic polyisoprene particles and permeates small sized sulfur and accelerator molecules into the interior of these particles thereby pre-vulcanizing the particles. The degree of pre-vulcanization is verified by isopropanol index test. The latex emulsion has post-vulcanization composition with accelerators that crosslink inter-particle region during post vulcanization cure cycle. The dipped synthetic polyisoprene article is substantially uniformly cured both in the inter-particle and intra-particle regions and reliably exhibits high cross link density, uniform distribution of double bonds in TEM and zinc segregation at the boundaries or original particles by electron microprobe analysis.Type: ApplicationFiled: June 28, 2017Publication date: October 19, 2017Inventors: David M. Lucas, Sugath Amarasekera, Dave Narasimhan, Adeline Ai Lin Kung
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Patent number: 9725539Abstract: A synthetic polyisoprene latex emulsion has pre-vulcanization composition and post vulcanization composition. The pre-vulcanization composition comprises soluble sulfur with high S8 ring structure that is catalytically broken by a zinc dithiocarbamate. Surfactants present in the pre-vulcanization composition wets synthetic polyisoprene particles and permeates small sized sulfur and accelerator molecules into the interior of these particles thereby pre-vulcanizing the particles. The degree of pre-vulcanization is verified by isopropanol index test. The latex emulsion has post-vulcanization composition with accelerators that crosslink inter-particle region during post vulcanization cure cycle. The dipped synthetic polyisoprene article is substantially uniformly cured both in the inter-particle and intra-particle regions and reliably exhibits high cross link density, uniform distribution of double bonds in TEM and zinc segregation at the boundaries or original particles by electron microprobe analysis.Type: GrantFiled: May 29, 2015Date of Patent: August 8, 2017Assignee: Ansell Healthcare Products LLCInventors: David M. Lucas, Sugarth Amarasekera, Dave Narasimhan, Adeline Ai Lin Kung
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Publication number: 20160033418Abstract: Provided for example is a combination glove comprising: (a) an top elastomer layer with an inner surface, the top elastomer layer being translucent or transparent; (b) an bottom elastomer layer with an outer surface, the bottom elastomer layer being darker than the top elastomer layer; and (c) a space or seam between the layers, wherein to either the inner-top or the outer-bottom surface has been adhered a hydrophilicity promoting composition of (i) a polyvinyl alcohol or (ii) an alkyl-aryl compound or a siloxane compound having a pendent one to two oxy-polymers, or (iii) a quaternary amine including an alkyl of C8 to C24, wherein the oxy-polymer is (1) a poly-oxyalkylene polymer that is predominantly oxyethylene or (2) a polyvinyl alcohol, wherein the hydrophilicity promoting composition enhances the spreading in the space or seam of any of the hydrophilic or aqueous fluid that breaches the top or bottom elastomer layer.Type: ApplicationFiled: July 22, 2015Publication date: February 4, 2016Inventors: Aik Hwee Eng, Thanabalan Thannimalai, Albert Khor, Lok Si Tang, Thi Hao Pham, David M. Lucas, Anthony Lopez, Choy Yuen Chak
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Patent number: 9149567Abstract: Provided herein are powder-free elastomeric articles exhibiting good antimicrobial and anti-blocking properties. Also provided herein are methods for the manufacture of such articles substantially free from antimicrobial interfering materials, as well as packaging means for maintaining antimicrobial efficacy.Type: GrantFiled: March 9, 2010Date of Patent: October 6, 2015Assignee: Ansell LimitedInventors: Aik Hwee Eng, Hee Meng Lai, Kuang Leng Lim, Koon Meow Ting, David M. Lucas
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Publication number: 20150259451Abstract: A synthetic polyisoprene latex emulsion has pre-vulcanization composition and post vulcanization composition. The pre-vulcanization composition comprises soluble sulfur with high S8 ring structure that is catalytically broken by a zinc dithiocarbamate. Surfactants present in the pre-vulcanization composition wets synthetic polyisoprene particles and permeates small sized sulfur and accelerator molecules into the interior of these particles thereby pre-vulcanizing the particles. The degree of pre-vulcanization is verified by isopropanol index test. The latex emulsion has post-vulcanization composition with accelerators that crosslink inter-particle region during post vulcanization cure cycle. The dipped synthetic polyisoprene article is substantially uniformly cured both in the inter-particle and intra-particle regions and reliably exhibits high cross link density, uniform distribution of double bonds in TEM and zinc segregation at the boundaries or original particles by electron microprobe analysis.Type: ApplicationFiled: May 29, 2015Publication date: September 17, 2015Inventors: David M. Lucas, Sugarth Amarasekera, Dave Narasimhan, Adeline Ai Lin Kung
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Patent number: 9074027Abstract: A synthetic polyisoprene latex emulsion has pre-vulcanization composition and post vulcanization composition. The pre-vulcanization composition comprises soluble sulfur with high S8 ring structure that is catalytically broken by a zinc dithiocarbamate. Surfactants present in the pre-vulcanization composition wets synthetic polyisoprene particles and permeates small sized sulfur and accelerator molecules into the interior of these particles thereby pre-vulcanizing the particles. The degree of pre-vulcanization is verified by isopropanol index test. The latex emulsion has post-vulcanization composition with accelerators that crosslink inter-particle region during post vulcanization cure cycle. The dipped synthetic polyisoprene article is substantially uniformly cured both in the inter-particle and intra-particle regions and reliably exhibits high cross link density, uniform distribution of double bonds in TEM and zinc segregation at the boundaries or original particles by electron microprobe analysis.Type: GrantFiled: June 5, 2013Date of Patent: July 7, 2015Assignee: Ansell Healthcare Products LLCInventors: David M. Lucas, Sugarth Amarasekera, Dave Narasimhan, Adeline Ai Lin Kung
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Patent number: 9074029Abstract: A synthetic polyisoprene latex emulsion has pre-vulcanization composition and post vulcanization composition. The pre-vulcanization composition comprises soluble sulfur with high S8 ring structure that is catalytically broken by a zinc dithiocarbamate. Surfactants present in the pre-vulcanization composition wets synthetic polyisoprene particles and permeates small sized sulfur and accelerator molecules into the interior of these particles thereby pre-vulcanizing the particles. The degree of pre-vulcanization is verified by isopropanol index test. The latex emulsion has post-vulcanization composition with accelerators that crosslink inter-particle region during post vulcanization cure cycle. The dipped synthetic polyisoprene article is substantially uniformly cured both in the inter-particle and intra-particle regions and reliably exhibits high cross link density, uniform distribution of double bonds in TEM and zinc segregation at the boundaries or original particles by electron microprobe analysis.Type: GrantFiled: February 10, 2014Date of Patent: July 7, 2015Assignee: Ansell Healthcare Products LLCInventors: David M. Lucas, Sugarth Amarasekera, Dave Narasimhan, Adeline Ai Lin Kung
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Patent number: 9044474Abstract: A method of (a) treating a lymphoproliferative disease in a subject in need thereof; (b) slowing the progression of lymphoproliferative disease in a subject who has been diagnosed with a lymphoproliferative disease; or (c) preventing or delaying development of a lymphoproliferative disease in a subject who is at risk of developing a lymphoproliferative disease. The method generally comprises administering to the individual an effective amount of a combination therapy comprising: i) at least one autophagy modulating agent, or a derivative, pharmaceutically acceptable salt thereof, or prodrug thereof; and ii) at least one CDK inhibitor agent, or a derivative, pharmaceutically acceptable salt thereof, or prodrug thereof, wherein the i) agent and the ii) agents are administered in amounts sufficient to enhance the cytotoxicity of the combination relative to the CDK inhibitor agent treatment alone.Type: GrantFiled: November 7, 2011Date of Patent: June 2, 2015Assignee: The Ohio State UniversityInventors: John C. Byrd, Amy J. Johnson, Emilia Mahoney, David M. Lucas, Michael R. Grever
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Publication number: 20150128329Abstract: A glove, including a polymeric, elastomeric, or latex composition, having a water-based emulsion of a polyisoprene polymer; a first accelerator comprising at least one of a thiourea, a benzothiazole sulphenamide, a thiazole, or a dialkyl dithiocarbamate, or combinations thereof, a second accelerator comprising a thiuram or a xanthogen, or a combination thereof, at least one anti-oxidant, at least one vulcanizing agent; and an activator, wherein a total amount of the first accelerator and the second accelerator ranges from 0.2 to 2.5 PHR of the polymeric, elastomeric, or latex composition and the polymeric, elastomeric, or latex composition is substantially free of diphenyl guanidine and/or casein.Type: ApplicationFiled: November 12, 2014Publication date: May 14, 2015Inventors: Koralalage Don Sugathananda Amarasekera, David M. Lucas, Dambadeni Arachchige Ruwani Upekshika Lalanthani
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Publication number: 20140255432Abstract: Disclosed herein are treatment methods, vaccination methods, compositions, co-therapeutic methods, combination therapeutic compositions and kits comprising silvestrol and silvestrol analogs alone or in combination with therapeutic and preventative therapies. Disclosed herein are also methods, compositions and kits that can be used to treat cancer, viral infections, to modulate the immune system or as preventative therapies.Type: ApplicationFiled: July 27, 2012Publication date: September 11, 2014Applicant: OHIO STATE INNOVATION FOUNDATIONInventors: Robert A. Baiocchi, John Thomas Patton, JR., David M. Lucas, Douglas Kinghorn, Michael Grever
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Patent number: 8770201Abstract: Condoms having an elastomeric layer and coating containing an anhydrous warming lubricant and at least one or more ingredients dispersed therein, the coating being disposed on one or both surfaces are provided. The ingredients disposed on the elastomeric layer can be solid particles or encapsulated ingredients that are insoluble in the anhydrous warming lubricant and soluble in water. Methods of producing and using these condoms are also provided.Type: GrantFiled: October 23, 2008Date of Patent: July 8, 2014Assignee: GlycoBioSciences Inc.Inventors: Michael S. Zedalis, Beng Sim Chuah, David M. Lucas, Angela M. Shiokawa, Jose R. Siqueira, Dave Narasimhan
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Publication number: 20140186628Abstract: A synthetic polyisoprene latex emulsion has pre-vulcanization composition and post vulcanization composition. The pre-vulcanization composition comprises soluble sulfur with high S8 ring structure that is catalytically broken by a zinc dithiocarbamate. Surfactants present in the pre-vulcanization composition wets synthetic polyisoprene particles and permeates small sized sulfur and accelerator molecules into the interior of these particles thereby pre-vulcanizing the particles. The degree of pre-vulcanization is verified by isopropanol index test. The latex emulsion has post-vulcanization composition with accelerators that crosslink inter-particle region during post vulcanization cure cycle. The dipped synthetic polyisoprene article is substantially uniformly cured both in the inter-particle and intra-particle regions and reliably exhibits high cross link density, uniform distribution of double bonds in TEM and zinc segregation at the boundaries or original particles by electron microprobe analysis.Type: ApplicationFiled: February 10, 2014Publication date: July 3, 2014Applicant: Ansell Healthcare Products LLCInventors: David M. Lucas, Sugath Amarasekera, Dave Narasimhan, Adeline Ai Lin Kung
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Publication number: 20140173805Abstract: A latex glove article with a fibrous coating bonded to the skin-contacting surface. Long length soft moisture absorbing fibers are attached to latex layer of a glove with a thin layer of polymeric latex adhesive forming a fibrous lining. The long length fibers have a length ranging from 4 to 100 times the thickness of the polymeric latex adhesive layer and therefore extend or project from the polymeric latex adhesive coating. The fibers penetrate the polymeric latex adhesive layer at one end or both end of the fiber to a depth of about 60% to about 100% of the adhesive thickness, leaving a substantial portion of the fiber available for soft contact with skin and sweat absorption. Due to the substantial thickness of the fibrous lining, an air gap is created between skin and the impervious latex layer establishing continual evaporation of absorbed sweat and evaporative cooling.Type: ApplicationFiled: February 25, 2014Publication date: June 26, 2014Inventors: Noorman Bin Abu Hassan, David M. Lucas, Nuzaimah Binti Mustafa
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Publication number: 20140165263Abstract: Fluid repellent coatings including a silicone coating for elastomeric gloves, and methods for treating gloves having elastomeric coatings, are disclosed.Type: ApplicationFiled: December 16, 2013Publication date: June 19, 2014Inventors: Thi Hao Pham, Norman W. Keane, Albert Khor, David M. Lucas, Mohamad Izwan Jaafar, Khadzrul Ariff Mohamad Baki
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Patent number: 8709573Abstract: A latex glove article with a fibrous coating bonded to the skin-contacting surface. Long length soft moisture absorbing fibers are attached to latex layer of a glove with a thin layer of polymeric latex adhesive forming a fibrous lining. The long length fibers extend or project from the polymeric latex adhesive coating. The fibers penetrate the polymeric latex adhesive layer at one end or both end of the fiber to a depth of about 60% to about 100% of the adhesive thickness, leaving a substantial portion of the fiber available for soft contact with skin and sweat absorption. Due to the substantial thickness of the fibrous lining, which is between about 4 and about 100 times the thickness of the thin layer of polymeric latex adhesive, an air gap is created between skin and the impervious latex layer establishing continual evaporation of absorbed sweat and evaporative cooling.Type: GrantFiled: March 20, 2009Date of Patent: April 29, 2014Assignee: Ansell Healthcare Products LLCInventors: Noorman Bin Abu Hassan, David M. Lucas, Nuzaimah Binti Mustafa
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Publication number: 20140005250Abstract: A method of (a) treating a lymphoproliferative disease in a subject in need thereof; (b) slowing the progression of lymphoproliferative disease in a subject who has been diagnosed with a lymphoproliferative disease; or (c) preventing or delaying development of a lymphoproliferative disease in a subject who is at risk of developing a lymphoproliferative disease. The method generally comprises administering to the individual an effective amount of a combination therapy comprising: i) at least one autophagy modulating agent, or a derivative, pharmaceutically acceptable salt thereof, or prodrug thereof; and ii) at least one CDK inhibitor agent, or a derivative, pharmaceutically acceptable salt thereof, or prodrug thereof, wherein the i) agent and the ii) agents are administered in amounts sufficient to enhance the cytotoxicity of the combination relative to the CDK inhibitor agent treatment alone.Type: ApplicationFiled: November 7, 2011Publication date: January 2, 2014Applicant: THE OHIO STATE UNIVERSITYInventors: John C. Byrd, Amy J. Johnson, Emilia Mahoney, David M. Lucas, Michael R. Grever