Patents by Inventor David M. Lynn
David M. Lynn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8071210Abstract: In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films.Type: GrantFiled: October 9, 2008Date of Patent: December 6, 2011Assignee: Wiscousin Alumni Research FoundationInventors: David M. Lynn, Maren E. Buck, Jingtao Zhang
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Publication number: 20110117138Abstract: The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.Type: ApplicationFiled: November 19, 2010Publication date: May 19, 2011Applicant: Wisconsin Alumni Research FoundationInventors: David M. Lynn, Adam D. Miller
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Patent number: 7943179Abstract: A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the inventive pH triggerable particles. Upon exposure to an acidic environment such as the endosome or phagosome of a cell, the particles dissolve or disrupt due to protonation or an increase in solubility of the pH triggering agent. Pharmaceutical compositions and methods of preparing and administering these particles are also described. These particles may be particularly useful in genetic vaccination.Type: GrantFiled: December 2, 2004Date of Patent: May 17, 2011Assignee: Massachusetts Institute of TechnologyInventors: Steven R. Little, David M. Lynn, Daniel G. Anderson, Robert S. Langer
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Patent number: 7883720Abstract: The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.Type: GrantFiled: July 7, 2004Date of Patent: February 8, 2011Assignee: Wisconsin Alumni Research FoundationInventors: David M. Lynn, Adam D. Miller
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Publication number: 20100048736Abstract: Materials and methods for the generation of polyelectrolyte multilayers that can erode to release cationic components. The multilayers comprise layers that contain one or more cations and one or more charge-dynamic anionic polymers. Charge-dynamic anionic polymers contain side chains having removable functional groups. Removal of the functional groups results in a change in the net change in the charge of the polymer which can disrupt interactions between cations and the anionic polymers and facilitate release of cations.Type: ApplicationFiled: June 5, 2009Publication date: February 25, 2010Inventors: Xianghui Liu, Jingtao Zhang, David M. Lynn
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Publication number: 20100036084Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: ApplicationFiled: July 23, 2009Publication date: February 11, 2010Applicant: Massachusetts Institute of TechnologyInventors: Robert S. Langer, David M. Lynn, David Putnam, Mansoor M. Amiji, Daniel G. Anderson
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Publication number: 20090170179Abstract: In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films.Type: ApplicationFiled: October 9, 2008Publication date: July 2, 2009Inventors: David M. Lynn, Maren E. Buck, Jingtao Zhang
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Publication number: 20090105375Abstract: Multilayered films, particularly ultrathin multilayered films comprising cationic polymers which are useful for controlled release of anionic species, particularly for controlled release of nucleic acids. The multilayer films herein are useful for temporal controlled released of anionic species, particularly one or more anionic peptides, proteins, nucleic acids or other anionic biological agents.Type: ApplicationFiled: October 9, 2008Publication date: April 23, 2009Inventors: David M. Lynn, Jingtao Zhang, Xianghui Liu
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Publication number: 20080286345Abstract: A composition for delivery of a molecule into a cell is provided. The composition includes a protein transduction domain that is conjugated to the molecule which is incorporated into a multilayered film. Preferably, the protein transduction domain is a cationic protein transduction domain. More preferably, the cationic protein transduction domain is nonaarginine, and the multilayered film includes polyelectrolyte multilayers. When the composition is presented to a cell, the multilayered film dissolves or erodes in physiological media, and the molecule is delivered into the cell.Type: ApplicationFiled: January 22, 2008Publication date: November 20, 2008Inventors: David M. Lynn, Ronald T. Raines, Christopher M. Jewell, Stephem M. Fuchs, Ryan M. Flessner
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Patent number: 7427394Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.Type: GrantFiled: May 28, 2003Date of Patent: September 23, 2008Assignees: Massachusetts Institute of Technology, The United States of Americas as represented by the Secretary of the ArmyInventors: Daniel G. Anderson, David M. Lynn, Akin Akinc, Robert S. Langer
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Patent number: 7112361Abstract: A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.Type: GrantFiled: October 24, 2002Date of Patent: September 26, 2006Assignee: Massachusetts Institute of TechnologyInventors: David M. Lynn, Eduardo Vazquez, Robert Langer, Paula T. Hammond
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Patent number: 6998115Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: GrantFiled: October 2, 2001Date of Patent: February 14, 2006Assignee: Massachusetts Institute of TechnologyInventors: Robert S. Langer, David M. Lynn, David Putnam, Mansoor M. Amiji, Daniel G. Anderson
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Publication number: 20040071654Abstract: Poly(&bgr;-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.Type: ApplicationFiled: May 28, 2003Publication date: April 15, 2004Inventors: Daniel G. Anderson, David M. Lynn, Akin Akinc, Robert S. Langer
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Publication number: 20030124368Abstract: A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.Type: ApplicationFiled: October 24, 2002Publication date: July 3, 2003Inventors: David M. Lynn, Eduardo Vazquez, Robert Langer, Paula T. Hammond
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Acid activation of ruthenium metathesis catalysts and living ROMP metathesis polymerization in water
Patent number: 6486279Abstract: Activation of ruthenium based catalyst compounds with acid to improve reaction rates and yields of olefin metathesis reactions, including ROMP, RCM, ADMET and cross-methasis reactions is disclosed. The ruthenium catalyst compounds are ruthenium carbene complexes of the general formula AxLyXzRu═CHR′ where x=0, 1 or 2, y=0, 1 or 2, and z=1 or 2 and where R′ is hydrogen or a substituted or unsubstituted alkyl or aryl, L is any neutral electron donor, X is any anionic ligand, and A is a ligand having a covalent structure connecting a neutral electron donor and an anionic ligand. The use of acid with these catalysts allows for reactions with a wide range of olefins in a variety of solvents, including acid-initiated RIM processes and living ROMP reactions of water-soluble monomers in water.Type: GrantFiled: June 14, 2001Date of Patent: November 26, 2002Assignee: California Institute of TechnologyInventors: David M. Lynn, Eric L. Dias, Robert H. Grubbs, Bernard Mohr -
Publication number: 20020131951Abstract: Poly(&bgr;-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: ApplicationFiled: October 2, 2001Publication date: September 19, 2002Inventors: Robert S. Langer, David M. Lynn, David Putnam, Mansoor M. Amiji, Daniel G. Anderson
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Acid activation of ruthenium metathesis catalysts and living ROMP metathesis polymerization in water
Publication number: 20020055598Abstract: Activation of ruthenium based catalyst compounds with acid to improve reaction rates and yields of olefin metathesis reactions, including ROMP, RCM, ADMET and cross-methasis reactions is disclosed. The ruthenium catalyst compounds are ruthenium carbene complexes of the general formula AxLyXzRu═CHR′ where x=0, 1 or 2, y=0, 1 or 2, and z=1 or 2 and where R′ is hydrogen or a substituted or unsubstituted alkyl or aryl, L is any neutral electron donor, X is any anionic ligand, and A is a ligand having a covalent structure connecting a neutral electron donor and an anionic ligand. The use of acid with these catalysts allows for reactions with a wide range of olefins in a variety of solvents, including acid-initiated RIM processes and living ROMP reactions of water-soluble monomers in water.Type: ApplicationFiled: June 14, 2001Publication date: May 9, 2002Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: David M. Lynn, Eric L. Dias, Robert H. Grubbs, Bernard Mohr -
Patent number: 6376690Abstract: The present invention generally relates to the discovery that the solubility of metal complexes may be readily manipulated by the addition of one or more solubility-enhancing compounds. This manipulation of the solubilities allows for the preparation of suitable samples for precise quantitative analysis and for the facile purification of the desired products from the reaction mixture containing one or more metal complexes. In one embodiment of the invention, the relative solubilities between two solutions are manipulated so as cause the metal complex found in a first solution to transfer to a second solution that is generally immiscible with the first solution. The metal complex is thus separated from the reaction mixture which comprises the first solution by the removal of the second solution.Type: GrantFiled: August 30, 1999Date of Patent: April 23, 2002Assignee: California Institute O TechnologyInventors: Robert H. Grubbs, Heather D. Maynard, David M. Lynn
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Acid activation of ruthenium metathesis catalysts and living ROMP metathesis polymerization in water
Patent number: 6284852Abstract: Activation of ruthenium based catalyst compounds with acid to improve reaction rates and yields of olefin metathesis reactions, including ROMP, RCM, ADMET and cross-metathesis reactions is disclosed. The ruthenium catalyst compounds are ruthenium carbene complexes of the general formula AxLyXzRu═CHR′ where x=0, 1 or 2, y=0, 1 or 2, and z=1 or 2 and where R′ is hydrogen or a substituted or unsubstituted alkyl or aryl, L is any neutral electron donor, X is any anionic ligand, and A is a ligand having a covalent structure connecting a neutral electron donor and an anionic ligand. The use of acid with these catalysts allows for reactions with a wide range of olefins in a variety of solvents, including acid-initiated RIM processes and living ROMP reactions of water-soluble monomers in water.Type: GrantFiled: October 29, 1998Date of Patent: September 4, 2001Assignee: California Institute of TechnologyInventors: David M. Lynn, Eric L. Dias, Robert H. Grubbs, Bernard Mohr -
Patent number: 5924597Abstract: A fragrance dispensing apparatus and method is disclosed for use in a multi-room building having an existing HVAC system ventilated by a forcing fan. The apparatus includes a plurality of fragrance containers, a plurality of solenoids, a plurality of programmable timers, and a single fan timer. A fragrance container is mounted in communication with the HVAC ductwork leading into a given room. Each fragrance container is controlled by a separate solenoid, which is in turn controlled by a separate programmable timer. All of the programmable timers are connected to a single fan timer, which controls the operation of the forcing fan. The method allows one or more of the programmable timers to activate corresponding containers to dispense fragrances as the forcing fan runs to distribute the fragrances into the rooms supplied by the ductwork.Type: GrantFiled: September 19, 1997Date of Patent: July 20, 1999Inventor: David M. Lynn