Abstract: The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: The present invention relates to sulfonylureas and sulfonylthioureas comprising a monocyclic imidazolyl group of formula (I): wherein Q is selected from O or S, R1 is an imidazolyl group, wherein the imidazolyl group is unsubstituted or substituted with one or more monovalent substituents, and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: A non-systematic convolutional decoder of a convolutionally encoded multi-level data stream includes a shift register and two or more paths of exclusive-OR (XOR) gates, arranged to reconstruct an original input information stream, each path having a quantiser arranged to quantise the signal to two levels, and a set of XOR gates arranged to match an encoding path in an associated convolutional encoder, and a selector arranged to feed an output from each path to a single input of the shift register. If the paths have differing values at their output, the selector may choose the value from the path based upon a function of the multi-level signals associated with each path, such as the path with the largest absolute signal level. The decoder provides a simple means for decoding signals while allowing the signal to also or instead be decoded using e.g. a Viterbi decoder if higher performance is required.

Abstract: A system for compensating for phase noise, with particular application in lidar, includes a compensation interferometer that receives a signal from a source, and splits it into a first and second path, with a path length difference ?? between them. Typically the path length is significantly less than that of the return distance to a target. The output of the compensation interferometer, which consists of phase noise generated in time ?? is vectorially summed during a time similar to a signal flight time to a target, and the result used to reduce phase noise present on measurements of a target. It further includes means for selecting ?? such that competing noise elements are reduced or optimised.

Abstract: A radio receiver includes a downconverter for downconverting dual sideband signals such as Binary Offset Carrier (BOC) signals from multiple sources to produce an upper and a lower sideband signal, and chip-matched filters for filtering each of the sideband signals. The output of each filter is provided to a series of separate channels, one for each source, where there are at least Early, Prompt and Late gates. Each gate has a nearest-neighbour sampler and a multiplier for multiplying with an appropriate part of a spreading code, a mixer for removing Doppler or other frequency offsets and an integrator. The invention provides a means for demodulating signals such as BOC modulated satellite navigation signals in an efficient manner by using a single downconverter for the received signals of interest from the multiple sources.

Abstract: A radio receiver includes a downconverter for downconverting dual sideband signals such as Binary Offset Carrier (BOC) signals from multiple sources to produce an upper and a lower sideband signal, and chip-matched filters for filtering each of the sideband signals. The output of each filter is provided to a series of separate channels, one for each source, where there are at least Early, Prompt and Late gates. Each gate has a nearest-neighbour sampler and a multiplier for multiplying with an appropriate part of a spreading code, a mixer for removing Doppler or other frequency offsets and an integrator. The invention provides a means for demodulating signals such as BOC modulated satellite navigation signals in an efficient manner by using a single downconverter for the received signals of interest from the multiple sources.

Abstract: Participant-provided qualitative or comment-style responses to inquiries may be processed to generate processed responses, which may then be evaluated by participants for ranking. The processed responses may reflect groups of similar qualitative responses to, among other things, simplify and reduce the amount of data that needs to be reviewed by the participants for ranking. On the other hand, the processed responses may have a one-to-one correspondence with the qualitative responses, and the grouping of similar responses may occur after the participant ranking. Grouping after participant ranking may have the benefit of, among other things, simplifying the grouping, as only highest ranked responses may need to be grouped.

Abstract: A method for the reception of a frequency hopped direct sequence spread spectrum signal includes acquiring the signal by splitting the received signal into a plurality of processing sub-channels, each corresponding to one or more hop frequencies; and within each sub-channel: i) subtracting any sub-carrier frequency from the received signal; ii) filtering the signal from (i) using a chip-matched filter; iii) selecting a sub-set of samples from the filtered signal; iv) correlating the sampled signal from step (iii) with a known reference signal to produce at least one correlator output. The output(s) from each sub-channel are provided to an input of a corresponding one or more common discrete time Fourier transforms (DTFT), and an output therefrom having a peak above a predetermined threshold is selected for further processing in the receiver. The method is a less expensive way of tracking the signal and can demodulate appropriately modulated signals.

Abstract: Methods and systems for payment assurance and claim pre-validation are described. In one embodiment, a pre-visit claim for health care related services is received for payment assurance. In response to the pre-visit claim, a payer is queried for pre-visit claim detail information indicating any payment or authorization issues for services to be rendered. The pre-visit claim may be updated in certain embodiments based on the pre-visit claim detail information, and an appointment may be scheduled for services. In other aspects, a claim for health care related services is received for pre-validation. In response, a payer is queried for claim detail information indicating any payment or authorization issues for the claim. The claim may be updated in certain embodiments based on the claim detail information, and payment for services rendered may be provided by a payer in response to a submitted claim.

Abstract: Some embodiments are directed to a method of determining the time of arrival of an incoming satellite signal at a receiver, including receiving an incoming signal, multiplying of the incoming signal by a first real-valued periodic modifying signal to produce a first modified output, correlating the first modified output to obtain a first correlation output, multiplying the incoming signal by a second real-valued periodic modifying signal to produce a second modified output, correlating the second modified output to produce a second correlation output and comparing the first correlation output with the second correlation output.

Abstract: A method for the reception of a frequency hopped direct sequence spread spectrum signal includes acquiring the signal by splitting the received signal into a plurality of processing sub-channels, each corresponding to one or more hop frequencies; and within each sub-channel: i) subtracting any sub-carrier frequency from the received signal; ii) filtering the signal from (i) using a chip-matched filter; iii) selecting a sub-set of samples from the filtered signal; iv) correlating the sampled signal from step (iii) with a known reference signal to produce at least one correlator output. The output(s) from each sub-channel are provided to an input of a corresponding one or more common discrete time Fourier transforms (DTFT), and an output therefrom having a peak above a predetermined threshold is selected for further processing in the receiver. The method is a less expensive way of tracking the signal and can demodulate appropriately modulated signals.

Abstract: Methods and systems for payment assurance and claim pre-validation are described. In one embodiment, a pre-visit claim for health care related services is received for payment assurance. In response to the pre-visit claim, a payer is queried for pre-visit claim detail information indicating any payment or authorization issues for services to be rendered. The pre-visit claim may be updated in certain embodiments based on the pre-visit claim detail information, and an appointment may be scheduled for services. In other aspects, a claim for health care related services is received for pre-validation. In response, a payer is queried for claim detail information indicating any payment or authorization issues for the claim. The claim may be updated in certain embodiments based on the claim detail information, and payment for services rendered may be provided by a payer in response to a submitted claim.

Abstract: A system for compensating for phase noise, with particular application in lidar, includes a compensation interferometer that receives a signal from a source, and splits it into a first and second path, with a path length difference ?? between them. Typically the path length is significantly less than that of the return distance to a target. The output of the compensation interferometer, which consists of phase noise generated in time ?? is vectorially summed during a time similar to a signal flight time to a target, and the result used to reduce phase noise present on measurements of a target. It further includes means for selecting ?? such that competing noise elements are reduced or optimised.

Abstract: Methods and systems for payment assurance and claim pre-validation are described. In one embodiment, a pre-visit claim for health care related services is received for payment assurance. In response to the pre-visit claim, a payer is queried for pre-visit claim detail information indicating any payment or authorization issues for services to be rendered. The pre-visit claim may be updated in certain embodiments based on the pre-visit claim detail information, and an appointment may be scheduled for services. In other aspects, a claim for health care related services is received for pre-validation. In response, a payer is queried for claim detail information indicating any payment or authorization issues for the claim. The claim may be updated in certain embodiments based on the claim detail information, and payment for services rendered may be provided by a payer in response to a submitted claim.

Abstract: Some embodiments are directed to a method of identifying a vehicle-borne transmitter emitting an interfering signal over a predefined frequency band. The method comprises monitoring the predefined frequency band at a first location to identify an emission of an interfering signal from a passing vehicle. If an interfering signal is detected, the method further comprises capturing a first image of the passing vehicle to enable an identity of the passing vehicle to be determined.

Abstract: A system for practitioner-patient network communicating real-time health data, location and prescription calendar scheduling is provided that enables health care practitioners to monitor patients in real-time by patient location. Prescriptions may be generated, amended, renewed, and authorized in real-time over network. Data transmitted over network may be packaged with a unique patient identity parsed into the data stream whereby unique security protocols ensure point-to-point delivery.

Abstract: An automated medical test data report, tracking, and patient matching system devised to enable secure transmittal of medical test results data over network between a hosting computing apparatus and at least one receiving computing apparatus is provided. Triple tiered security is enabled by action of paired cryptographic keys, sequencing of data by generation of a randomized and securely-shared sequencing order, and fragmentation of data from a data stream into sortable data packets routable to separate and remotely connected partitions by appending a sort code into each data packet collectively prevent compromise of data in transmission over network.

Abstract: Systems and methods for defining a composite view and using the definition of the composite view to obtain, aggregate, analyze, and present data from a variety of data sources to a user. These systems and methods may allow for the definition of a visual framework to aggregate and display related data. This visual framework, or composite view, may in turn be composed of a master view and a set of subviews, each of which may display data collected from a particular data source according to a particular format. By interacting with the master view data from a variety of data sources can be displayed.

Abstract: The sharing of objects may be executed by performing various share type administrations. Objects may be shared directly to a site or may be made available indirectly for reuse by a site. The objects shared and made available for reuse may be added to the site to which they are shared and made available for reuse. References to the objects shared and made available for reuse are stored in repositories in response to, and in accordance with, the share type administration performed. The storage of the references to objects is based on privileges associated with at least one of a repository, a site and a user. Objects made available for reuse by, and shared to, a site may be made unavailable for reuse by, and unshared to, the site through the execution of a share type administration.

Abstract: A method for coordinating medical treatments and in-care patient tracking system is set forth wherein a patient peripheral enables determination of patient location data, patient identification data, and treatment data, by sensed spatiotemporal relationships of the patient peripheral within a designated area. Proximity of the patient peripheral with a practitioner peripheral enables automated association of treatment data to a patient record alongside practitioner identification data. Treatment data generated, such as collected samples and other data, effects automatic assignment of the patient identity to relevant data and materials. Inventory is trackable, and doses administered are reportable automatically to the patient record.