Abstract: The invention provides compositions and methods for treating tuberous sclerosis complex (TSC). In particular, provided are condensed tuberins (cTuberins), cTuberin nucleic acids, and recombinant adeno-associated viruses (rAAVs) carrying a cTuberin nucleic acid for treating a patient with TSC.

Abstract: A fluid device generally comprises a staging reservoir which may receive a volume of fluid flowing from a primary reservoir via a coupler upon operation of an actuator, wherein the staging reservoir is usable to measure fluid within the device in order to dispense a desired amount of fluid.

Abstract: A fluid device generally comprises a staging reservoir which may receive a volume of fluid flowing from a primary reservoir via a coupler upon operation of an actuator, wherein the staging reservoir is usable to measure fluid within the device in order to dispense a desired amount of fluid.

Abstract: A system for mounting an accessory to a cycle has a mounting part 400, a receiving part 500, and a locking member 508. The mounting part 400 has an axially extending member 402 and at least one transversely projecting lug 406. The receiving part 500 has a recess for receiving the member 402 and the lug(s) 406 when the receiving part 500 is in a receiving/releasing position, and at least one lip 506 for engaging with the lug(s) 406 to retain the mounting part 400 when the receiving part 500 is angularly moved relative to the mounting part 400. The locking member 508 is operable between the mounting part 400 and the receiving part 500, and is moveable between an unlocked position and a securing position to selectively retain the receiving part 500 in a plurality of angularly offset locked positions relative to the mounting part 400.

Abstract: A waste disposal apparatus, such as a waste disposal container or unit that is configured to receive used personal care products in a discreet and sanitary manner Instances of incontinence, menstruation or uncontrollable bodily functions can be a personal situation that is otherwise unknown to others. However, current receptacles available to dispose of used personal care products fail to provide for a hygienic, easily accessible and discreet that is designed for small spaces, such as a home bathroom or public restroom stall.

Abstract: A waste disposal apparatus, such as a waste disposal container or unit that is configured to receive used personal care products in a discreet and sanitary manner. Instances of incontinence, menstruation or uncontrollable bodily functions can be a personal situation that is otherwise unknown to others. However, current receptacles available to dispose of used personal care products fail to provide for a hygienic, easily accessible and discreet that is designed for small spaces, such as a home bathroom or public restroom stall.

Abstract: A system for mounting an accessory to a cycle has a mounting part 400, a receiving part 500, and a locking member 508. The mounting part 400 has an axially extending member 402 and at least one transversely projecting lug 406. The receiving part 500 has a recess for receiving the member 402 and the lug(s) 406 when the receiving part 500 is in a receiving/releasing position, and at least one lip 506 for engaging with the lug(s) 406 to retain the mounting part 400 when the receiving part 500 is angularly moved relative to the mounting part 400. The locking member 508 is operable between the mounting part 400 and the receiving part 500, and is moveable between an unlocked position and a securing position to selectively retain the receiving part 500 in a plurality of angularly offset locked positions relative to the mounting part 400.

Abstract: A system for mounting an accessory to a cycle has a mounting part (400), a receiving part (500), and a locking member (508). The mounting part (400) has an axially extending member (402) and at least one transversely projecting lug (406). The receiving part (500) has a recess for receiving the member (402) and the lug(s) (406) when the receiving part (500) is in a receiving/releasing position, and at least one lip (506) for engaging with the lug(s) (406) to retain the mounting part (400) when the receiving part (500) is angularly moved relative to the mounting part (400). The locking member (508) is operable between the mounting part (400) and the receiving part (500), and is moveable between an unlocked position and a securing position to selectively retain the receiving part (500) in a plurality of angularly offset locked positions relative to the mounting part (400).

Abstract: A system for mounting an accessory to a cycle has a mounting part (400), a receiving part (500), and a locking member (508). The mounting part (400) has an axially extending member (402) and at least one transversely projecting lug (406). The receiving part (500) has a recess for receiving the member (402) and the lug(s) (406) when the receiving part (500) is in a receiving/releasing position, and at least one lip (506) for engaging with the lug(s) (406) to retain the mounting part (400) when the receiving part (500) is angularly moved relative to the mounting part (400). The locking member (508) is operable between the mounting part (400) and the receiving part (500), and is moveable between an unlocked position and a securing position to selectively retain the receiving part (500) in a plurality of angularly offset locked positions relative to the mounting part (400).

Abstract: A waste disposal apparatus, such as a waste disposal container or unit that is configured to receive used personal care products in a discreet and sanitary manner. Instances of incontinence, menstruation or uncontrollable bodily functions can be a personal situation that is otherwise unknown to others. However, current receptacles available to dispose of used personal care products fail to provide for a hygienic, easily accessible and discreet that is designed for small spaces, such as a home bathroom or public restroom stall.

Abstract: A waste disposal apparatus, such as a waste disposal container or unit that is configured to receive used personal care products in a discreet and sanitary manner Instances of incontinence, menstruation or uncontrollable bodily functions can be a personal situation that is otherwise unknown to others. However, current receptacles available to dispose of used personal care products fail to provide for a hygienic, easily accessible and discreet that is designed for small spaces, such as a home bathroom or public restroom stall.

Abstract: A wearable support assembly is provided which includes a belt strap configured to be secured about a user's hips/waist and a carrier frame which is pivotally attached to the belt strap at two pivot points which are spaced apart along the belt strap to create a substantially lateral pivot axis when the belt is worn by the user, where the relative position of the two pivot points can be adjusted with respect to the belt, the carrier frame is located behind the user when the support assembly is worn by the user and the carrier frame spans the distance between each pivot point on the belt strap with a gap separating the belt strap and the carrier frame.

Abstract: An apparatus 1 for attaching an article 3 to a vehicle 9, having a first engagement member 24 and a second engagement member 26 spaced from the first engagement member along a longitudinal axis and that is slidable relative to the first engagement member along the longitudinal axis between an engaged position and a disengaged position. The apparatus 1 has a transverse plane extending generally through the apparatus and coincident with the longitudinal axis. The first and second engagement members 24, 26 each have a retaining portion 24b, 26b that is non-perpendicular relative to the transverse plane and configured to be received by respective engagement features 103, 107 on the article 3.

Abstract: The present invention relates to a connection device for a pannier for a vehicle and a pannier having such a connection device. The connection device includes a pivotable support member having an attachment arrangement for attaching to the vehicle. The pivotable support member is adapted to be pivoted between an attachment position, in which the attachment arrangement is exposed for attachment to the vehicle, and a concealed position. The present invention provides a connection device having an attachment arrangement. The attachment arrangement can be displaced so as not to interfere with objects, e.g., getting snared or caught.

Abstract: A carrier for golf clubs and accessories. The carrier has a semi-rigid or rigid body (3) defining a main storage compartment, the main storage compartment containing a tapered storage compartment (21) and two side compartments (23, 25). A width WI of the tapered storage compartment (21) at or towards a top of the tapered storage compartment is greater than a width W2 of the tapered storage compartment (21) at or towards a base of the tapered storage compartment. Each side compartment (23, 25) has a width W4 at or towards a base of said side compartment that is greater than a width W3 at or towards a top of that side compartment.

Abstract: An apparatus for accessing longitudinal bores which includes: a length of resilient tube configured to be extendible along at least a portion of its length; wherein one end of the resilient tube includes a utility head thereon; and wherein the other end of the tube is configured to directly or indirectly connect to, and receive a force from, a physical energy source.

Abstract: Support assemblies for attaching to an existing device, such as a bicycle frame, are provided. Support assemblies are suited for carrying loads and providing additional storage and transport capacity. Assemblies of the present invention contemplate a primary support member for carrying or receiving articles, and additional or secondary members for supporting the primary support and communicating with the existing device.

Abstract: A wearable support assembly is provided which includes a belt strap configured to be secured about a user's hips/waist and a carrier frame which is pivotally attached to the belt strap at two pivot points which are spaced apart along the belt strap to create a substantially lateral pivot axis when the belt is worn by the user, where the relative position of the two pivot points can be adjusted with respect to the belt, the carrier frame is located behind the user when the support assembly is worn by the user and the carrier frame spans the distance between each pivot point on the belt strap with a gap separating the belt strap and the carrier frame.

Abstract: This invention relates to a bicycle carrier for mounting to a vehicle. The carrier includes a mounting portion for attaching the carrier to a vehicle, a main member attached to the mounting portion, and a pair of wheel supports affixed relative to the main member and at an angle of between about 35 degrees and about 55 degrees to a substantially horizontal axis, such that upper ends of the wheel supports are closer together than lower ends of the wheel supports. Each wheel support includes a channel for partial receipt of a bicycle wheel. The wheel supports are configured to support the wheels of bicycles having a range of wheel diameters and/or wheel base lengths.