Abstract: The present invention relates to a method of chemovaccination against Plasmodium infection comprising administering to a patient an effective amount of a selective inhibitor of plasmepsin X, or a pharmaceutically acceptable salt thereof.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for optimizing package delivery and confirmation are disclosed. In one embodiment, the system's processors accesses a first image of an assigned delivery location captured by a first computing device. The first image comprises an annotation indicating a specific location at the assigned delivery location for delivery of a parcel. At a display device of a second computing device, a real-time image stream comprising the annotation is captured by a camera of the second computing device is displayed. The annotation is overlaid within the real-time image stream based on comparing the first image received from the first computing device to the real-time image stream. The system further captures, from the real-time image stream, a second image when the parcel is positioned at the specific location based on the annotation overlaid within the real-time image stream.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: A diverter assembly for a vehicle includes a spacer and a diverter coupled to the spacer; the spacer is configured to couple to a cooling assembly that provides access to an engine compartment of the vehicle, and when the spacer is coupled to the cooling assembly the diverter is aligned with a screen of the cooling assembly. The spacer may include an aperture configured to receive a fastener that secures a screen assembly of the cooling assembly to a frame of the cooling assembly. The fastener may simultaneously secure the diverter assembly to the frame of the cooling assembly.

Abstract: According to an embodiment of a first aspect of the invention, there is provided a distributed network comprising a plurality of nodes. Each of the plurality of nodes is configured to run one or more computational units comprising its own unit state. The network is configured to individually execute, by an execution subset of the plurality of nodes, s set of execution messages in a deterministic manner, thereby mutating the unit states of one or more of the computational units of the execution subset. The network is further configured to regularly make, by the nodes of the execution subset, a read snapshot of the unit states of the one or more computational units of the execution subset and to provide, by one or more nodes of the execution subset, user access to the read snapshot. Further aspects of the invention relate to a corresponding computer-implemented method, a node, a computer program product and a software architecture.

Abstract: An aspect of the invention relates to a computer-implemented method for charging and paying for a use of resources of a distributed network. The distributed network comprises a plurality of nodes, wherein each of the plurality of nodes is configured to run one or more computational units. The one or more computational units comprise one or more application units for providing application services to users of the distributed network. The embodied method comprises steps of running, by each user of the network, one or more local user gas accounts at one or more of the application units and processing, via the local user gas accounts, payments for the use of the resources of the distributed network. Further aspects relate to a distributed network, a node of a distributed network and a corresponding computer program product.

Abstract: A method of improving electrical conduction across an impaired region of a tissue (e.g., myocardial tissue), includes applying an electrically conductive wiring carbon nanotube fibers) across the impaired region. The electrically conductive wiring can become associated with non-impaired regions of the tissue on opposite sides of the impaired region by suturing. The method can also be utilized to treat or prevent cardiac arrhythmia in a subject (e.g., ventricular arrhythmia). The electrically conductive wiring includes carbon nanotubes, such as carbon nanotube fibers, Such electrically conductive wiring can be used to transmit electrical signals to a tissue or sense electrical signals from the tissue. Suture threads including carbon nanotubes, such as carbon nanotube fibers, are provided.

Abstract: A diverter assembly for a vehicle includes a spacer and a diverter coupled to the spacer; the spacer is configured to couple to a cooling assembly that provides access to an engine compartment of the vehicle, and when the spacer is coupled to the cooling assembly the diverter is aligned with a screen of the cooling assembly. The spacer may include an aperture configured to receive a fastener that secures a screen assembly of the cooling assembly to a frame of the cooling assembly. The fastener may simultaneously secure the diverter assembly to the frame of the cooling assembly.

Abstract: Some embodiments of the present disclosure pertain to methods of improving electrical conduction across an impaired region of a tissue (e.g., myocardial tissue) by applying an electrically conductive material (e.g., carbon nanotube fibers) across the impaired region. The electrically conductive materials can become associated with non-impaired regions of the tissue on opposite sides of the impaired region by suturing. Such methods can also be utilized to treat or prevent cardiac arrhythmia in a subject (e.g., ventricular arrhythmia). Additional embodiments of the present disclosure pertain to electrical wirings that include carbon nanotubes, such as carbon nanotube fibers. Such electrical wirings can be used to transmit electrical signals to a tissue or sense electrical signals from the tissue. In some embodiments, the present disclosure also pertains to suture threads that include carbon nanotubes, such as carbon nanotube fibers.

Abstract: A method and system for supply chain product and process development collaboration. The supply chain is comprised of at least one project, each project having a part (or family of parts), a supplier of the part, and a customer. The system may include a data storage and retrieval device operably connected to a processor. The system's functions include collaboration tools and security based on the users' project roles. The method uses a methodology that ensures certain requirements are met prior to satisfying the methodology. The system and method of the present invention ensures that current, applicable methodologies are applied to a specific part and allows for collaboration between the customer and supplier during all phases of the project. Because all projects in a supply chain are present, a user can navigate throughout the supply chain. The supply chain's reporting functions permit determination of potential performance risks and the source thereof.

Abstract: An information server system is responsive to page specifications to render information pages at a plurality of clients that use different client software and that have widely different characteristics. Information pages are authored in a generic page specification format that is not limited to any particular client or client software. In response to a request for the information page, the server system selects and executes a page renderer that is compatible with the client software of the client requesting the information. The page renderer converts the page specification of the information page to an instruction sequence that is tailored particularly for the requesting client. The conversion is accomplished by selecting and executing a plurality of independently-executable pane renderers.

Abstract: An information server system is responsive to page specifications to render information pages at a plurality of clients that use different client software and that have widely different characteristics. Information pages are authored in a generic page specification format that is not limited to any particular client or client software. In response to a request for the information page, the server system selects and executes a page renderer that is compatible with the client software of the client requesting the information. The page renderer converts the page specification of the information page to an instruction sequence that is tailored particularly for the requesting client. The conversion is accomplished by selecting and executing a plurality of independently-executable pane renderers.

Abstract: An information server system is responsive to page specifications to render information pages at a plurality of clients that use different client software and that have widely different characteristics. Information pages are authored in a generic page specification format that is not limited to any particular client or client software. In response to a request for the information page, the server system selects and executes a page renderer that is compatible with the client software of the client requesting the information. The page renderer converts the page specification of the information page to an instruction sequence that is tailored particularly for the requesting client. The conversion is accomplished by selecting and executing a plurality of independently-executable pane renderers.

Abstract: A method and system for supply chain product and process development collaboration. The supply chain is comprised of at least one product, where each project is defined as a part (or family of parts), a supplier to supply the part, and a customer to be supplied the part. In one embodiment, the system includes a data storage and retrieval devise to hold project data, which, for each project, includes a project identifier, a part identified, a supplier identifier, a customer identifier, data representative of a methodology applicable to the project, and data representative of at least one control associated with processing of the project. The system and method of the present invention ensures that current methodologies applicable to a project are applied, and allows for collaboration between the customer and supplier during all phases of product and process design, development, and manufacture.

Abstract: A hypermedia-based navigation system includes a plurality of information providers and one or more clients. Databases of available hyperlink targets are maintained by the information providers. Each of the databases is searchable by means of one or more query attributes supported by the database and relating to the available hyperlink targets. A hypermedia document might contain a soft hyperlink, consisting of a query formulation specified in terms of query attributes and of values for said query attributes. A client resolves a soft hyperlink by querying at least one of the databases with the query formulation to locate one or more hyperlink targets having attributes and attribute values that satisfy the query formulation. The soft hyperlink can additionally contain executable rules. The client executes these rules prior to submitting the query formulation to the database. Each rule, when it executes, potentially adds search predicates to the original query formulation.