Abstract: Novel compounds, compositions, and methods of using and preparing the same, which maybe useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: An apparatus includes a switch module that selectively turns on a switch to connect an input power conductor connected to a voltage source to a motor in a sequence. The switch for each phase is turned on for a portion of a cycle of a fundamental frequency of the voltage source. A source phase module determines a phase of the AC voltage source, a back-EMF phase module determines a phase of a back-EMF of the motor, and a torque module determines when a phase difference between the phase of the AC voltage source and the phase of the back-EMF is within a phase range indicative of a positive motor torque. A pulse module enables the switches in response to the phase difference having a phase within the phase range and disables the switches in response to the phase difference having a phase not in the phase range.

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: A motor controller includes a motor winding heater function. The motor controller applies a predefined current to one or more of the motor windings without the use of additional dedicated motor winding heater devices. The motor controller serves to control the operation of the motor, while the motor windings serve both as a heater at times and to produce torque at times.

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: An apparatus for a quasi variable frequency motor controller is includes a DFC module that applies a first frequency to a motor as part of a discrete frequency control (“DFC”) method for motor starting. The first frequency includes a discrete frequency in a plurality of discrete frequencies of the DFC method and each discrete frequency includes a frequency lower than a fundamental frequency of an alternating current (“AC”) voltage source providing power to the motor. The apparatus includes a torque module that determines when motor torque generated by the motor reaches a negative torque threshold and a next frequency module that applies a second frequency to the motor in response to the torque module determining that the motor torque has reached the negative torque threshold. The second frequency is a next frequency in the DFC method.

Abstract: An apparatus includes a switch module that selectively turns on a switch to connect an input power conductor connected to a voltage source to a motor in a sequence. The switch for each phase is turned on for a portion of a cycle of a fundamental frequency of the voltage source. A source phase module determines a phase of the AC voltage source, a back-EMF phase module determines a phase of a back-EMF of the motor, and a torque module determines when a phase difference between the phase of the AC voltage source and the phase of the back-EMF is within a phase range indicative of a positive motor torque. A pulse module enables the switches in response to the phase difference having a phase within the phase range and disables the switches in response to the phase difference having a phase not in the phase range.

Abstract: An apparatus for a quasi variable frequency motor controller is includes a DFC module that applies a first frequency to a motor as part of a discrete frequency control (“DFC”) method for motor starting. The first frequency includes a discrete frequency in a plurality of discrete frequencies of the DFC method and each discrete frequency includes a frequency lower than a fundamental frequency of an alternating current (“AC”) voltage source providing power to the motor. The apparatus includes a torque module that determines when motor torque generated by the motor reaches a negative torque threshold and a next frequency module that applies a second frequency to the motor in response to the torque module determining that the motor torque has reached the negative torque threshold. The second frequency is a next frequency in the DFC method.

Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Abstract: The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.