Abstract: A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defined above with a compound of the following formula (8); and (c) recovering a compound of formula (I) as defined above. The compound of formula (I) is a promising modulator of p300/CBP activity that has potential utility in treating cancers, including prostate cancer, haematological cancers, bladder cancer and lung cancer.

Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: A security device for a building-related passenger transport system includes a microcontroller having a memory, a processor and a communication interface. A security module is stored in the memory and, when it is executed on the processor, receives security-relevant signals from components of the passenger conveyor system, evaluates the signals with regard to a security problem and transmits a warning signal to a controller of the passenger conveyor system in the event of a security problem. An update module is stored in the memory and, when it is executed on the processor, receives a software package via the communication interface and updates at least parts of the security module with the software package. The microcontroller is configured such that the security module is able to be amended only by the update module.

Abstract: Apparatus and methods of forming boxes from template blanks includes moving the blank forward on a drive line while one or more side panel fingers raise and lower various side panels of the blank in an alternating fashion. One or more holders maintain the side panels in position as the blank moves forward on the drive line. The raised and lowered side panels rigidify various panels from which they extend. The rigidified panels may be less susceptible to bending along false scores that extend transversely across the blank during folding and bending steps of the box forming process.

Abstract: An elevator system has a central control unit for generating control signals and/or processing sensor signals and controlling functions of the system, a plurality of field devices distributed inside a structure accommodating the system, preferably along an elevator shaft, and a field bus system for interchanging the signals between the control unit and the field devices. Each field device outputs sensor signals generated by a sensor and/or receives control signals to be implemented by an actuator. Data packets including the signals are interchanged in a serial manner between the control unit and all field devices in a summation frame method using a closed ring topology. Each field device has a driver to insert the sensor signals into the data packet or to remove the control signals from the data packet. Data and signal transmission is thereby carried out quickly and safely in a safety circuit of the elevator system.

Abstract: Apparatus and methods of forming boxes from template blanks includes moving the blank forward on a drive line while one or more side panel fingers raise and lower various side panels of the blank in an alternating fashion. One or more holders maintain the side panels in position as the blank moves forward on the drive line. The raised and lowered side panels rigidify various panels from which they extend. The rigidified panels may be less susceptible to bending along false scores that extend transversely across the blank during folding and bending steps of the box forming process.

Abstract: A machine for forming packing templates includes a infeed system that can feed multiple feeds of sheet material into the machine without repositioning the infeed system or forming creases or bends in the sheet material. The machine also includes a separation and cutting systems with one or more cutting tables and biased knives that cut the sheet material packaging templates. The machine also includes creasing roller(s) that forms creases in the sheet material. The machine also includes a system for reducing or eliminating the impact of irregularities in the sheet material.

Abstract: A method for configuring security related configuration parameters is used in a passenger transport installation that includes at least one sensor exchanging sensor signals with a control. The sensor detects operating parameters within the passenger transport installation and emits corresponding sensor signals. The control controls security related functions of the passenger transport installation taking into account the sensor signals and the configuration parameters. The method includes: comparing the sensor signals with a predefined key signal pattern; operating the control temporarily in a configuration mode exclusively if the compared sensor signals correspond to the key signal pattern; and configuring the security related configuration parameters during the configuration mode. An installation-specific sensor (e.g. optical sensor or magnetic field sensor) functions as an interface to put the control into configuration mode in a targeted manner, e.g.

Abstract: A machine for forming packing templates includes a infeed mechanism that can feed multiple feeds of sheet material into the machine without repositioning the infeed mechanism or forming creases or bends in the sheet material. The machine also includes a separation and cutting systems with one or more cutting tables and biased knives that cut the sheet material packaging templates. The machine also includes creasing roller(s) that forms creases in the sheet material. The machine also includes a system for reducing or eliminating the impact of irregularities in the sheet material.

Abstract: A car safety supervising unit (SSU) for an elevator having an elevator car displaceable within an elevator shaft includes at least one sensor for sensing car-related parameters and outputting corresponding car-related signals, an I/O interface for inputting input signals into the car SSU and for outputting output signals to external devices and a signal processing unit for processing at least one of the car-related signals and the input signals and for generating the output signals. In an installation operation mode, the signal processing unit processes exclusively the car-related signals and generates the output signals based exclusively on the car-related signals whereby the car SSU accomplishes basic safety functions for safely operating the elevator with a limited number of available sensors. In a normal operation mode, the signal processing unit processes both the car-related signals and the input signals and generates the output signals based on both.

Abstract: A process for producing a compound of the following formula (I) which process comprises: (a) treating a compound of the following formula (5) with a compound of the following formula (6) to generate an intermediate compound of the following formula (7); (b) treating a compound of formula (7) as defined above with a compound of the following formula (8); and (c) recovering a compound of formula (I) as defined above. The compound of formula (I) is a promising modulator of p300/CBP activity that has potential utility in treating cancers, including prostate cancer, haematological cancers, bladder cancer and lung cancer.

Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: A monitoring device for an elevator system is used with an assembly device for assembling a shaft retrofit and a method for monitoring an assembly platform. The monitoring device monitors movements of an elevator car and includes a sensor system for detecting a movement variable and at least one analysis device that evaluates the detected movement variable and compares it to a threshold. If the threshold is exceeded, a signal output is triggered to actuate a brake/catching device. The monitoring device selects the threshold from specified thresholds based on a state of the monitoring device. The specified thresholds include at least one normal operation threshold, and the monitoring device indicates a normal state as soon as specified connection elements are connected to it. The monitoring device further contains a checking routine for determining a state of the monitoring device, and selects the threshold from specified thresholds based on the state.

Abstract: An elevator includes a drive, a car operatively connected to the drive to traverse along a travel path, at least one guide rail positioned along the travel path to guide the car, a safety brake arranged on the car to exert a braking force on the guide rail, and a safety system. The safety system includes a first safety control unit and a second safety control unit that monitor a safety condition of the elevator. The first safety control unit outputs a stop signal to the drive, in particular to a drive brake and/or to a frequency converter of the drive, and the second safety control unit outputs a trigger signal to the safety brake to bring the elevator into a proper safety condition when an impermissible safety condition of the elevator is detected.

Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: A system and method for determining an elevator car position uses position markers situated in the elevator shaft and each assigned a discrete car position, first and second detection devices on the elevator car detecting first and second position markers respectively, and an evaluation unit that determines first and second discrete car positions based on the detected first and second position markers respectively. A single interpolation device of the position determining system determines first and second interpolated car positions. The evaluation unit determines first and second car positions based on the first and second discrete car positions and the first and second interpolated car positions respectively. The interpolation device generates an interpolation parameter that characterizes a position of the first detection device relative to the first position marker and determines the first and second interpolated car positions on the basis of the interpolation parameter.

Abstract: A compound which is a benzimidazole of formula (I): wherein X is a 5-membered heteroaryl group selected from the following: or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: A method for configuring security related configuration parameters is used in a passenger transport installation that includes at least one sensor exchanging sensor signals with a control. The sensor detects operating parameters within the passenger transport installation and emits corresponding sensor signals. The control controls security related functions of the passenger transport installation taking into account the sensor signals and the configuration parameters. The method includes: comparing the sensor signals with a predefined key signal pattern; operating the control temporarily in a configuration mode exclusively if the compared sensor signals correspond to the key signal pattern; and configuring the security related configuration parameters during the configuration mode. An installation-specific sensor (e.g. optical sensor or magnetic field sensor) functions as an interface to put the control into configuration mode in a targeted manner, e.g.

Abstract: The presently disclosed subject matter relates to compositions, systems and methods of screening one or more species of polypeptide in a complex mixture of polypeptides, e.g., multi-subunit proteins. For example, the subject matter relates to ligands used in connection with affinity capillary electrophoresis, as well as methods and systems for detecting polypeptides in a mixture of multimers that include multispecific antibodies, e.g., bispecific antibodies.

Abstract: An elevator system has a drive, a car, a plurality of safety function components for providing safety functions at various positions, and a safety monitoring system with a plurality of safety monitoring units for monitoring all of the safety function components. The monitoring units have an input interface for reading in data or signals and an output interface for outputting control signals to an assigned member of the safety function components, at least some of the monitoring units being connected via data exchange channels. The monitoring units are organized in a master-slave hierarchy, with one unit designed as a master unit, and at least one other unit designed as a slave unit. The decentralized and distributed monitoring units, each having data processing capability, and the master-slave organization result in the elevator system exhibiting a high security level with low cabling complexity and cost expenditure, in particular for high rise elevators.