Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.

Abstract: A computing device comprising a secure browser extension for a web browser monitors for satisfaction of one or more operating conditions to identify whether one or more unauthorized applications are intercepting web browser communications. Based on satisfaction of at least one operating condition, the secure browser extension of the computing device sends an HTTPS request to a known service via the web browser. The secure browser extension receives an HTTPS response to the HTTPS request via the web browser. The secure browser extension determines whether the certificate included in the HTTPS response is trusted by the secure browser extension. Based on determining the certificate is not trusted, the secure browser extension terminates the web browser session and generates a notification for display at the computing device that indicates web browser communications are compromised.

Abstract: A timecoding technique for determining and assigning timecodes for variable frame rate video. Content identified for timecode assignment is decoded, and for sequential frames of the content, portions of timestamps are compared to determine if the frames are from a same time period (e.g., from the same second in time). For a subsequent frame from the same time period, an index is atomically incremented, a timecode generated from a combination of the time period and the index, and the timecode assigned to the frame. For a subsequent frame from a different time period, the index is initialized, a timecode generated from a combination of the different time period and the initialized index, and the timecode assigned to the frame. Accumulated durations of frames may be used in place of timestamps, in some instances.

Abstract: A card accessory device including, among other things, one or more processors and memory storing instructions that, when executed by the one or more processors, are configured to cause the card accessory device to receive, from a terminal in communication with the card, one or more messages comprising a complete message indicative of successfully reading the card and a read error message indicative that there was an error in reading the card, identify one or more predetermined sequences based on the one or more messages, and perform via a rumble pack, one or more predetermined vibration sequences comprising a first vibration sequence associated with the complete message and a second vibration sequence associated with the read error message in a predetermined pattern.

Abstract: Various embodiments of an automated adaptive bitrate (“ABR”) encoding system and method that encodes an input video into a set of encoded video streams for ABR delivery, also known as an ABR ladder. The automated ABR encoding system encodes the input video into an initial number of speculative encodings, based on respectively determined resolution and quality level settings for the individual speculative encodings. It then estimates quality scores for a plurality of potential output encodings based on respective output statistics of the speculative encodings. It selects a plurality of better quality output encodings from the plurality of potential output encodings based on the quality scores. It then encodes the input video a second time into the plurality of better quality output encodings. The automated ABR encoding system selects one or more output encodings from the plurality of better quality output encodings to include in the ABR ladder.

Abstract: A cemetery geospatial mapping system and methods are provided for interactive map-based searching of cemetery properties. The cemetery geospatial mapping system comprises a mapping tools system that includes a component systems package. The component systems package comprises a mapping system that enables end-users to add GPS coordinates to cemetery property records, automates mapping and overlaying of the cemetery properties onto satellite imagery, and enables the end-users to visually interact with information associated with the cemetery properties. A dynamic pricing system uses machine-learning algorithms to analyze data so as to provide the end-users with an optimal price recommendation for each property and unit of inventory. The dynamic pricing system maximizes profits based on predefined characteristics associated with the properties and units of inventory. A host site is stored on an application server system and accessible to the end-users by way of a communications network, such as the Internet.

Abstract: A timecoding technique for determining and assigning timecodes for variable frame rate video. Content identified for timecode assignment is decoded, and for sequential frames of the content, portions of timestamps are compared to determine if the frames are from a same time period (e.g., from the same second in time). For a subsequent frame from the same time period, an index is atomically incremented, a timecode generated from a combination of the time period and the index, and the timecode assigned to the frame. For a subsequent frame from a different time period, the index is initialized, a timecode generated from a combination of the different time period and the initialized index, and the timecode assigned to the frame. Accumulated durations of frames may be used in place of timestamps, in some instances.

Abstract: Systems and methods for objectively assessing physical performance of a subject and generating programs specifically tailored to correct any physical deficiencies identified during that assessment. Generally, the assessments may produce results in binary format so that the assessments may be conducted objectively. Additionally, the recommended exercise programs may be generated based on the results of those assessments so that the recommended exercise programs target the identified physical deficiencies.

Abstract: A timecoding technique for determining and assigning timecodes for variable frame rate video. Content identified for timecode assignment is decoded, and for sequential frames of the content, portions of timestamps are compared to determine if the frames are from a same time period (e.g., from the same second in time). For a subsequent frame from the same time period, an index is atomically incremented, a timecode generated from a combination of the time period and the index, and the timecode assigned to the frame. For a subsequent frame from a different time period, the index is initialized, a timecode generated from a combination of the different time period and the initialized index, and the timecode assigned to the frame. Accumulated durations of frames may be used in place of timestamps, in some instances.

Abstract: A cryogenic fluid containment system is disclosed. The system can store a fluid such as hydrogen at a cryogenic temperature and pressure. As the fluid naturally warms, the fluid can be directed to a portion of a liquefaction system that is configured to perform a cooling technique on the fluid. The cooling techniques may be Joule-Thomson cooling techniques. The liquefaction system may be equipped to perform both non-Joule-Thomson cooling techniques and Joule-Thomson cooling techniques. The system is configured to direct fluid to an appropriate portion of the liquefaction system, which may be based at least in part upon a Joule-Thomson coefficient of the fluid.

Abstract: A timecoding technique for determining and assigning timecodes for variable frame rate video. Content identified for timecode assignment is decoded, and for sequential frames of the content, portions of timestamps are compared to determine if the frames are from a same time period (e.g., from the same second in time). For a subsequent frame from the same time period, an index is atomically incremented, a timecode generated from a combination of the time period and the index, and the timecode assigned to the frame. For a subsequent frame from a different time period, the index is initialized, a timecode generated from a combination of the different time period and the initialized index, and the timecode assigned to the frame. Accumulated durations of frames may be used in place of timestamps, in some instances.

Abstract: An autonomous moving object comprising a radar sensor is provided. The radar sensor is configured to, during movement, acquire data sets representing reflections from surface portions located within a distance range, and, at least at a sequence of occasions, illuminate a surface region and acquire a data set representing, for each of a set of distances within said distance range, an amplitude and a phase of reflected radar signals received from surface portions located at said distance. Said surface regions comprise common sub-region illuminated at each of said occasions. A radar signal processor is configured to receive the data sets acquired at each of said sequence of occasions. The received data sets form a collection of data sets, wherein each data set of said collection comprises a data subset pertaining to said common sub-region. A surface classifier processor is configured to output a classification of a surface type of the surface based on said collection of data subsets.

Abstract: Techniques for accommodating irregular timing information in streamed media data are described. According to some embodiments, at least a portion of a media stream that includes a video component is received, the video component including a plurality of video frames and video timing data, and wherein the media stream includes an indication of a video frame rate. A first duration of a first video frame of the plurality of video frames is determined to be different than an expected video frame duration, wherein the expected video frame duration is based at least in part on the indication of the video frame rate. A timestamp of at least one video frame of the plurality of video frames is adjusted to change the first duration.

Abstract: A cemetery geospatial mapping system and methods are provided for interactive map-based searching of cemetery properties. The cemetery geospatial mapping system comprises a mapping tools system that includes a component systems package. The component systems package comprises a mapping system that enables end-users to add GPS coordinates to cemetery property records, automates mapping and overlaying of the cemetery properties onto satellite imagery, and enables the end-users to visually interact with information associated with the cemetery properties. A dynamic pricing system uses machine-learning algorithms to analyze data so as to provide the end-users with an optimal price recommendation for each property and unit of inventory. The dynamic pricing system maximizes profits based on predefined characteristics associated with the properties and units of inventory. A host site is stored on an application server system and accessible to the end-users by way of a communications network, such as the Internet.

Abstract: Rotor support structures for industrial machines are disclosed. The support structures may include a rigid base component including a top portion, a slide plate positioned above the rigid base component, and a bearing housing for a rotor, coupled to the slide plate. The bearing housing and the slide plate may be configured to slide or move over the rigid base component. The support structure may also include a plurality of retention blocks coupled to the bearing housing. Each of the plurality of retention blocks may include a moveable retention pin positioned through each of the plurality of retention blocks. The axial movement of the bearing housing and slide plate may compensate for thermal expansion of a turbine shell and/or may reduce vibrations of the rotor and bearing housing during operation of the industrial machines.

Abstract: A data storage subsystem having a plurality of data compression engines configured to compress data, each having a different compression algorithm. A data handling system is configured to determine a present rate of access to data; select at least one sample of data; determine the greatest degree of compression of said data compression engines; determine the compression ratios of the operated data compression engines with respect to the selected sample(s); compressing said selected at least one sample with a plurality of said data compression engines at said selected tier; operate a selected data compression engines with respect to the selected sample and determine the greatest degree of compression of the data compression engines; compress the data from which the sample was selected with one of the operated data compression engines determined to have the greatest degree of compression; and store the compressed data in data storage repositories.

Abstract: A method for searching data on multiple domains includes transmitting a search query to an enterprise domain; receiving, from the enterprise domain, enterprise content matching the search query; receiving, from the enterprise domain, a search query normalized for searching a social site domain, the normalized search query being the search query in a format recognizable by the social site domain; transmitting the normalized search query to the social site domain; and receiving, from the social site domain, social site content matching the normalized search query.

Abstract: Electric generators are described herein integrating thermoelectric and piezoelectric components. In some embodiments, an electric generator comprises a thermoelectric film having a plurality of lateral p-n junctions across a face of the film, the lateral p-n junctions established at interfaces between p-type regions and n-type regions. A piezoelectric film is coupled to the thermoelectric film and an electrode is coupled to the piezoelectric film.

Abstract: A new and distinct evergreen blueberry variety with zero chill requirement named ‘BLUECSOL12’, characterized by the following combination of traits: medium to strong plant vigor, upright growth habit, ovate leaf shape, campanulate corolla shape and moderate conspicuousness of ridges on corolla tube, oblate fruit shaped, extra-large fruit-size, moderate bloom intensity, high sweetness and acidity, and firm fruit. Latin name of the genus and species: Vaccinium corymbosum L.