Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: A transactional method and system of managing access to API services based on the performance of computational tasks by an end-user is disclosed. The system and method are configured to identify requests from an end-user to an API for services that are associated with a transactional cost. This cost is passed on to the end-user by generation of a computational task assignment to be completed by the client computing system. Once the assignment has been performed, the end-user may be granted access to the requested service.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: Anti-angiogenic treatments, for example treatment of ocular neovascularization or cancer, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of treating or preventing fibrosis and compounds for use in such methods are described.

Abstract: A transactional method and system of managing access to API services based on the performance of computational tasks by an end-user is disclosed. The system and method are configured to identify requests from an end-user to an API for services that are associated with a transactional cost. This cost is passed on to the end-user by generation of a computational task assignment to be completed by the client computing system. Once the assignment has been performed, the end-user may be granted access to the requested service.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: Anti-angiogenic treatments, for example treatment of ocular neovascularization or cancer, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of treating or preventing fibrosis and compounds for use in such methods are described.

Abstract: A measurement process, intended for measuring at least one wheel of a train, including an acquisition step, during which a plurality of profiles of at least a part of the wheel are acquired by plurality of optical sensors, as the train moves in front of the optical sensors, a mapping step, during which, for each optical sensor, the profiles acquired by the optical sensor are joined by a control module, to obtain a map of the part of the wheel further transformed into a cloud of points, a rejoining step, during which the clouds of points obtained from the optical sensors are joined to form a three-dimensional image of the wheel, and an analysis step, during which a plurality of reference points and reference distances are measured on the three-dimensional image.

Abstract: The present invention provides a wafer product decorating apparatus comprising a laser, a collimator, at least one galvanometer driven mirror, and an aspheric scan lens, the apparatus being positionable relative to the wafer product to be decorated wherein the apparatus is configured to provide a laser beam having a spot size of from 100 to 750 ?m in diameter on the surface of the product to be decorated and a substantially flat focal plane, characterised in that the focal plane has a depth of field of from 5 mm to 20 mm and that the focal plane of the laser beam is from 5 mm to 30 mm above or below the surface of the product to be decorated. The invention also provides a process for decorating a wafer product.

Abstract: Anti-angiogenic treatments, for example treatment of ocular neovascularization or cancer, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of treating or preventing fibrosis and compounds for use in such methods are described.

Abstract: Anti-angiogenic treatments, for example treatment of ocular neovascularization or cancer, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of treating or preventing fibrosis and compounds for use in such methods are described.

Abstract: A measurement process, intended for measuring at least one wheel of a train, including an acquisition step, during which a plurality of profiles of at least a part of the wheel are acquired by plurality of optical sensors, as the train moves in front of the optical sensors, a mapping step, during which, for each optical sensor, the profiles acquired by the optical sensor are joined by a control module, to obtain a map of the part of the wheel further transformed into a cloud of points, a rejoining step, during which the clouds of points obtained from the optical sensors are joined to form a three-dimensional image of the wheel, and an analysis step, during which a plurality of reference points and reference distances are measured on the three-dimensional image.

Abstract: Anti-angiogenic treatments, for example treatment of ocular neovascularization or cancer, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of treating or preventing fibrosis and compounds for use in such methods are described.

Abstract: The present invention provides a wafer product decorating apparatus comprising a laser, a collimator, at least one galvanometer driven mirror, and an aspheric scan lens, the apparatus being positionable relative to the wafer product to be decorated wherein the apparatus is configured to provide a laser beam having a spot size of from 100 to 750 ?m in diameter on the surface of the product to be decorated and a substantially flat focal plane, characterised in that the focal plane has a depth of field of from 5 mm to 20 mm and that the focal plane of the laser beam is from 5 mm to 30 mm above or below the surface of the product to be decorated. The invention also provides a process for decorating a wafer product.

Abstract: The present invention relates to a method and apparatus for assisting with automated task management. In one embodiment, an apparatus for assisting a user in the execution of a task, where the task includes one or more workflows required to accomplish a goal defined by the user, includes a task learner for creating new workflows from user demonstrations, a workflow tracker for identifying and tracking the progress of a current workflow executing on a machine used by the user, a task assistance processor coupled to the workflow tracker, for generating a suggestion based on the progress of the current workflow, and a task executor coupled to the task assistance processor, for manipulating an application on the machine used by the user to carry out the suggestion.

Abstract: A multi-city wavelength link architecture is used to distribute spectral bands received on input optical signals among output optical signals. Such an architecture may include an optical wavelength cross connect having multiple input ports, multiple output ports, and a wavelength routing element that selectively routes wavelength components between one optical signal and multiple optical signal. Such an optical wavelength cross connect will generally receive cross-connect-input optical signals at the input ports and transmit cross-connect-output optical signals from the output ports. Methods are used to increase the number of cities that may be accommodated by the architecture without disrupting through traffic between the existing cities.

Abstract: The invention relates to thiophene carboxamides of formula (I), wherein A, R1, R2, R3, R4, R5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: The present invention relates to a method and apparatus for assisting with automated task management. In one embodiment, an apparatus for assisting a user in the execution of a task, where the task includes one or more workflows required to accomplish a goal defined by the user, includes a task learner for creating new workflows from user demonstrations, a workflow tracker for identifying and tracking the progress of a current workflow executing on a machine used by the user, a task assistance processor coupled to the workflow tracker, for generating a suggestion based on the progress of the current workflow, and a task executor coupled to the task assistance processor, for manipulating an application on the machine used by the user to carry out the suggestion.

Abstract: The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin K.