Patents by Inventor David Moureau
David Moureau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141175Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: June 26, 2023Publication date: May 2, 2024Inventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Publication number: 20230392071Abstract: Green excitable tandem dyes are provided. Tandem dyes of embodiments of the invention include: a non-conjugated polymeric backbone; one or more green excitable donor fluorophores linked to the non-conjugated polymeric backbone; and one or more acceptor fluorophores linked to the non-conjugated polymeric backbone; where the donor and acceptor fluorophores are in energy transfer relationship. Also provided are methods of making and using the tandem dyes, as well as kits that include the dyes and find use in embodiments of the methods.Type: ApplicationFiled: May 25, 2023Publication date: December 7, 2023Inventors: Glenn Bartholomew, David Moureau
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Publication number: 20230324374Abstract: Tandem dyes having internally positioned sensors are provided. Tandem dyes of embodiments of the invention include a peptidic scaffold comprising: one or more donor-fluor amino acid residues each conjugated to a pendant donor fluorophore; one or more acceptor-fluor amino acid residues each conjugated to a pendant acceptor fluorophore; and an internal amino acid residue conjugated to a sensor, e.g., a specific binding member, e.g., for a target analyte. In tandem dyes of embodiments of the invention, the donor and acceptor fluorophores of the are in energy transfer relationship. Also provided are methods of making and using the tandem dyes, as well as kits that include the dyes that find use in embodiments of the methods.Type: ApplicationFiled: March 28, 2023Publication date: October 12, 2023Inventors: Glenn Bartholomew, Brian Wall, David Moureau
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Publication number: 20230314418Abstract: Single domain antibody/polymeric fluorescent tandem dye conjugates are provided. Aspects of the provided conjugates include: a single domain antibody having one or more polymeric tandem fluorescent dyes conjugated thereto. In some instances, the polymeric tandem fluorescent dye includes: (i) a polymeric backbone made up of non-conjugated repeat units; (ii) a plurality of pendant donor chromophore groups each independently linked to a non-conjugated repeat unit of the polymeric backbone; and (iii) one or more pendant acceptor fluorophores linked to a non-conjugated repeat unit of the polymeric backbone, wherein pendant donor and acceptor fluorophores are in energy transfer relationship. Also provided are methods of using the conjugates, e.g., in methods of evaluating a sample for the presence of a target analyte, and kits comprising the conjugates that find use in embodiments of the methods.Type: ApplicationFiled: March 27, 2023Publication date: October 5, 2023Inventors: David Moureau, Stephanie Rigaud
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Publication number: 20230295441Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: May 24, 2023Publication date: September 21, 2023Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 11732138Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: September 28, 2022Date of Patent: August 22, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Publication number: 20230235177Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: September 28, 2022Publication date: July 27, 2023Inventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Patent number: 11702547Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: November 19, 2021Date of Patent: July 18, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 11492493Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: December 19, 2018Date of Patent: November 8, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Publication number: 20220089877Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: November 19, 2021Publication date: March 24, 2022Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 11214688Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: August 26, 2020Date of Patent: January 4, 2022Assignee: Becton, Dickinson and CompanyInventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20200392346Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: August 26, 2020Publication date: December 17, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 10844228Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: March 28, 2019Date of Patent: November 24, 2020Assignee: Becton, Dickinson and CompanyInventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20200002540Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: March 28, 2019Publication date: January 2, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20190194467Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: December 19, 2018Publication date: June 27, 2019Inventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Publication number: 20180036639Abstract: A system for creating and publishing story-driven games can provide various user interfaces which enable one or more game creators to construct frames, input story narratives, incorporate third-party multimedia content, configure deterministic and/or non-deterministic transitioning between frames, compile and publish games to multiple game marketplaces.Type: ApplicationFiled: August 3, 2017Publication date: February 8, 2018Inventors: David Moureau Reid, Gregory John Buron, Marc Anthony Racine, Chad Jeremy Riddle
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Patent number: 9614229Abstract: Non-flammable electrolyte compositions for lithium metal primary batteries and the cells containing these electrolytes are described. The electrolyte compositions comprise one or more partially or fully fluorinated functionalized short chain polyethers with one or more lithium salts, and may include one or more cosolvents, and may have one or more fire retardants added. Said short chain functionalized fluorinated polyethers have much better ionic conductivity than the alkyl terminated fluorinated polyethers or long chain perfluoropolyethers, which provide superior flame resistance without sacrificing overall battery performance. Heat resistant, non-flammable primary lithium cells are also disclosed.Type: GrantFiled: September 30, 2014Date of Patent: April 4, 2017Assignee: MAXPOWER, INC.Inventors: Lin-Shu Du, David Moureau
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Publication number: 20160093895Abstract: Non-flammable electrolyte compositions for lithium metal primary batteries and the cells containing these electrolytes are described. The electrolyte compositions comprise one or more partially or fully fluorinated functionalized short chain polyethers with one or more lithium salts, and may include one or more cosolvents, and may have one or more fire retardants added. Said short chain functionalized fluorinated polyethers have much better ionic conductivity than the alkyl terminated fluorinated polyethers or long chain perfluoropolyethers, which provide superior flame resistance without sacrificing overall battery performance. Heat resistant, non-flammable primary lithium cells are also disclosed.Type: ApplicationFiled: September 30, 2014Publication date: March 31, 2016Inventors: Lin-Shu Du, David Moureau