Abstract: Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

Abstract: A self-priming pump assembly is disclosed. In an illustrative embodiment, the self-priming pump assembly includes a motor, a main pump having a main pump impeller, a vacuum pump having a vacuum pump impeller, and a drive shaft driven by the motor. The main pump impeller and the vacuum pump impeller may be directly coupled to and driven by the drive shaft, and may rotate about the rotation axis of the drive shaft. In some instances, the vacuum pump impeller is situated between the motor and the main pump impeller, while in other instances, the main pump impeller may be situated between the vacuum pump impeller and the motor. In some cases, bearings may be provided at or near the vacuum pump to help support the vacuum pump relative to the drive shaft.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. A float may be provided, wherein when the fluid level in the reservoir reaches a desired level, the float opens a float valve to let air into the reservoir to maintain the desired level. The float valve may have a capacity that is greater than or equal to the pumping capacity of the vacuum pump, or at least large enough to make up for a difference between the pumping capacity of the vacuum pump and an amount of fluid that can be pumped by the centrifugal pump from the reservoir.

Abstract: A self-priming pump assembly is disclosed. In an illustrative embodiment, the self-priming pump assembly includes a motor, a main pump having a main pump impeller, a vacuum pump having a vacuum pump impeller, and a drive shaft driven by the motor. The main pump impeller and the vacuum pump impeller may be directly coupled to and driven by the drive shaft, and may rotate about the rotation axis of the drive shaft. In some instances, the vacuum pump impeller is situated between the motor and the main pump impeller, while in other instances, the main pump impeller may be situated between the vacuum pump impeller and the motor. In some cases, bearings may be provided at or near the vacuum pump to help support the vacuum pump relative to the drive shaft.

Abstract: A vacuum pump having components that are subject to wear may be adjusted to compensate for the wear. In some instances, a vacuum pump may include a housing and an impeller disposed at least partially within the housing. A gap between the housing and the impeller may be adjustable to compensate for wear. In some cases, the housing may include a ring that may be moved to adjust a tolerance (or gap) between the ring and the impeller. In some instances, the ring may be rotated to adjust this gap. In other instances, the ring may be translated to adjust the tolerance.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A vacuum pump having components that are subject to wear may be adjusted to compensate for the wear. In some instances, a vacuum pump may include a housing and an impeller disposed at least partially within the housing. A gap between the housing and the impeller may be adjustable to compensate for wear. In some cases, the housing may include a ring that may be moved to adjust a tolerance (or gap) between the ring and the impeller. In some instances, the ring may be rotated to adjust this gap. In other instances, the ring may be translated to adjust the tolerance.

Abstract: A vacuum pump having components that are subject to wear may be adjusted to compensate for the wear. In some instances, a vacuum pump may include a housing and an impeller disposed at least partially within the housing. A gap between the housing and the impeller may be adjustable to compensate for wear. In some cases, the housing may include a ring that may be moved to adjust a tolerance (or gap) between the ring and the impeller. In some instances, the ring may be rotated to adjust this gap. In other instances, the ring may be translated to adjust the tolerance.

Abstract: A trailer and fuel tank assembly are disclosed. The fuel tank preferably forms the body of the trailer. The fuel tank may include a recess in the top surface for receiving the motor and/or pump, which may lower the pump closer to the ground to increase the suction performance of the pump. The bottom surface of the fuel tank may be bowed upward. This may cause any contaminants in the fuel tank to collect along the edges of the tank. Drain ports, positioned near the edges of the tank, can then be used to drain the contaminants from the tank. To easily attach accessories to the trailer, one or more track bars may be mounted to the trailer body. The track bars preferably include an elongate channel and an elongate slot. By placing an insert inside of the channel and bolting the accessory to the insert through the longitudinally extending slot, the accessories can be easily attached to the trailer.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A method for the direct measurement of large strains in ropes in situ using a plastic optical fiber, for example, perfluorocarbon or polymethyl methacrylate and Optical Time-Domain Reflectometer or other light time-of-flight measurement instrumentation. Protective sheaths and guides are incorporated to protect the plastic optical fiber. In one embodiment, a small rope is braided around the plastic optical fiber to impose lateral compressive forces to restrain the plastic optical fiber from slipping and thus experience the same strain as the rope. Methods are described for making reflective interfaces along the length of the plastic optical fiber and to provide the capability to measure strain within discrete segments of the rope. Interpretation of the data allows one to calculate the accumulated strain at any point in time and to determine if the rope has experienced local damage.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.

Abstract: A pumping system is disclosed that includes a vacuum source. The pumping system includes a motor coupled to a centrifugal pump and a separator defining a reservoir in fluid communication with an inlet of the centrifugal pump. A water liquid ring vacuum pump having an inlet is provided in fluid communication with the reservoir of the separator. Accordingly, the vacuum pump may provide the required vacuum to prime the pump. To backflush that pumping system, the pumping system may include a first valve provided between the discharge port of the vacuum pump and the reservoir of the separator. A second valve may be provided between the reservoir of the separator and the inlet of the water liquid ring vacuum pump. During normal operation, the first valve fluidly connects the discharge of the vacuum pump to the atmosphere and the second valve fluidly connects the inlet of the vacuum pump to the reservoir of the separator.

Abstract: A trailer and fuel tank assembly are disclosed. The fuel tank preferably forms the body of the trailer. The fuel tank may include a recess in the top surface for receiving the motor and/or pump, which may lower the pump closer to the ground to increase the suction performance of the pump. The bottom surface of the fuel tank may be bowed upward. This may cause any contaminants in the fuel tank to collect along the edges of the tank. Drain ports, positioned near the edges of the tank, can then be used to drain the contaminants from the tank. To easily attach accessories to the trailer, one or more track bars may be mounted to the trailer body. The track bars preferably include an elongate channel and an elongate slot. By placing an insert inside of the channel and bolting the accessory to the insert through the longitudinally extending slot, the accessories can be easily attached to the trailer.

Abstract: A self priming pump system that includes a motor coupled to a centrifugal pump for driving the centrifugal pump. A separator having a reservoir is provided for storing a limited amount of pumped fluid in advance of the centrifugal pump. A vacuum source provides a vacuum suction to the reservoir to draw pumped fluid into the reservoir to prime the pump. To increase the reliability of the vacuum pump system, a deflector and/or extension may be provided in the reservoir to help prevent pumped fluid from entering the vacuum pump input. Also, the configuration of a tank used to store liquid for the vacuum pump system may be configured to separate and collect sediments near a drain port, which then can be easily drained. For positive head pressures, one or more valves may be used to prevent pumped fluid from escaping the reservoir, if desired.