Patents by Inventor David N. Krag
David N. Krag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230235026Abstract: Compositions and methods involving effector cells armed with antiviral antibodies are disclosed herein. Such compositions may also include additional antiviral treatments and may be used, for example, to treat subjects having a viral infection (e.g., SARS-CoV-2).Type: ApplicationFiled: April 13, 2021Publication date: July 27, 2023Applicant: Moonshot Antibodies, LLCInventors: David N. Krag, Girja S. Shukla, Stephanie C. Fournier, Sunny Yujing Sun
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Publication number: 20220169746Abstract: Compositions and methods involving anti-neoantigen antibodies and/or effector cells armed with anti-neoantigen antibodies are disclosed herein. Such compositions may also include immune checkpoint inhibitors and may be used, for example, in the treatment of cancers.Type: ApplicationFiled: February 26, 2020Publication date: June 2, 2022Applicant: The University of Vermont and State Agricultural CollegeInventors: David N. Krag, Girja S. Shukla, Stephanie C. Fournier, Sunny Yujing Sun
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Publication number: 20110130655Abstract: Implantable devices and methods for external beam radiation treatments are disclosed. One embodiment of an implantable device for guided radiation therapy comprises an active marker configured to be positioned within the patient and to transmit a non-ionizing wireless signal in response to a non-ionizing wirelessly transmitted source energy. The device further includes a fastening unit coupled to the active marker and configured to (a) hold the marker within a desired distance of a target in the tissue and (b) inhibit deformation of tissue from moving the active marker relative to the target.Type: ApplicationFiled: November 30, 2010Publication date: June 2, 2011Inventors: Eric D. Nielson, Steven C. Dimmer, David N. Krag, Timothy P. Mate, Roland Perez, Fergus Quigley
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Patent number: 7229960Abstract: The invention provides methods and compositions for treating subjects using Grb7 antagonists. Specifically disclosed are Grb7 antagonists that bind selectively to Grb7 and interfere with the ability of Grb7 to bind to its native ligands. These compositions are useful in the prevention and treatment of disorders characterized by abnormal interaction of Grb7 with its native ligands (e.g., ErbB2).Type: GrantFiled: November 5, 2001Date of Patent: June 12, 2007Assignee: University of Vermont and State Agricultural CollegeInventors: Stephanie C. Pero, David N. Krag, Lyn Oligino
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Patent number: 7098302Abstract: The invention provides methods and compositions for diagnosing and treating subjects using EBPs. Specifically disclosed are peptides and peptidomimetics that bind selectively to the extracellular domain of ErbB2. These compositions are useful in the prevention and treatment of disorders characterized by ErbB2 overexpression (e.g., breast cancer).Type: GrantFiled: October 15, 2002Date of Patent: August 29, 2006Assignee: University of Vermont and State Agricultural CollegeInventors: David N. Krag, Stephanie C. Pero, Lyn Oligino
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Patent number: 6918919Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.Type: GrantFiled: March 22, 2001Date of Patent: July 19, 2005Assignee: Calypso Medical Technologies, Inc.Inventor: David N. Krag
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Patent number: 6698433Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.Type: GrantFiled: January 14, 2002Date of Patent: March 2, 2004Assignee: Calypso Medical Technologies, Inc.Inventor: David N. Krag
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Patent number: 6675810Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.Type: GrantFiled: September 14, 2001Date of Patent: January 13, 2004Assignee: Calypso Medical Technologies, Inc.Inventor: David N. Krag
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Publication number: 20030216309Abstract: The invention provides methods and compositions for diagnosing and treating subjects using EBPs. Specifically disclosed are peptides and peptidomimetics that bind selectively to the extracellular domain of ErbB2. These compositions are useful in the prevention and treatment of disorders characterized by ErbB2 overexpression (e.g., breast cancer).Type: ApplicationFiled: October 15, 2002Publication date: November 20, 2003Applicant: University of Vermont and State Agricultural CollegeInventors: David N. Krag, Stephanie C. Pero, Lyn Oligino
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Publication number: 20030105000Abstract: The invention provides methods and compositions for treating subjects using Grb7 antagonists. Specifically disclosed are Grb7 antagonists that bind selectively to Grb7 and interfere with the ability of Grb7 to bind to its native ligands. These compositions are useful in the prevention and treatment of disorders characterized by abnormal interaction of Grb7 with its native ligands (e.g., ErbB2).Type: ApplicationFiled: November 5, 2001Publication date: June 5, 2003Inventors: Stephanie C. Pero, David N. Krag, Lyn Oligino
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Publication number: 20020143357Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.Type: ApplicationFiled: January 14, 2002Publication date: October 3, 2002Inventor: David N. Krag
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Patent number: 6401722Abstract: A method of stabilizing a tissue mass, using a system (8) that includes temperature sensors (10), a scanner (80), and a cryoprobe (220). The sensors provide temperature information with respect to a tissue portion adjacent thereto. The sensors include an identification (ID) code and an ID decoder. The ID decoder compares the sensor ID code to an ID code contained in an interrogation signal provided by the scanner. If the codes match, the sensor transmits the temperature information to the scanner, which processes and displays the temperature information in a humanly recognizable form. The method includes the step of inserting a cryoprobe into a tissue volume to be stabilized so that a portion of the cryoprobe projects therefrom. Then, the tissue volume is frozen while monitoring the size or temperature of the tissue volume. Freezing is terminated when the tissue volume is frozen (or reaches a first temperature level), and then removed while grasping the cryoprobe so as to stabilize the tissue volume.Type: GrantFiled: November 18, 1999Date of Patent: June 11, 2002Assignee: Calypso Medical Technologies, Inc.Inventor: David N. Krag
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Patent number: 6363940Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.Type: GrantFiled: May 14, 1998Date of Patent: April 2, 2002Assignee: Calypso Medical Technologies, Inc.Inventor: David N. Krag
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Publication number: 20020013596Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.Type: ApplicationFiled: September 14, 2001Publication date: January 31, 2002Inventor: David N. Krag
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Publication number: 20010018594Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.Type: ApplicationFiled: March 22, 2001Publication date: August 30, 2001Applicant: Calypso Medical, Inc.Inventor: David N. Krag
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Patent number: 6015390Abstract: A system (8) and method for stabilizing a tissue mass, using temperature sensors (10), a scanner (80), and a cryoprobe (220). The sensors provide temperature information with respect to a tissue portion adjacent thereto. The sensors include an identification (ID) code and an ID decoder. The ID decoder compares the sensor ID code to an ID code contained in an interrogation signal provided by the scanner. If the codes match, the sensor transmits the temperature information to the scanner, which processes and displays the temperature information in a humanly recognizable form. The method includes the step of inserting a cryoprobe into a tissue volume to be stabilized so that a portion of the cryoprobe projects therefrom. Then, the tissue volume is frozen while monitoring the size or temperature of the tissue volume. Freezing is terminated when the tissue volume is frozen (or reaches a first temperature level), and then removed while grasping the cryoprobe so as to stabilize the tissue volume.Type: GrantFiled: June 12, 1998Date of Patent: January 18, 2000Assignee: D. Krag LLCInventor: David N. Krag