Abstract: A metered volume microfluidic device can include fluid flow microfluidics. The fluid flow microfluidics can include an inflow channel, a metered volume chamber positioned to receive working fluid from the inflow channel, a metered volume outflow channel positioned to receive and direct a metered volume of the working fluid when discharged from the metered volume chamber, and a capillary check valve. The capillary check valve can allow excess working fluid to exit the metered volume chamber when filling the metered volume chamber via the inflow channel. The capillary check valve can also prevent excess working fluid that has passed there through from being reintroduced into the metered volume chamber when the working fluid is discharged into the metered volume outflow channel.

Abstract: A print liquid supply interface structure is provided, to fluidically connect a fluid supply container to a receiving station, comprising a liquid channel having at least one liquid channel wall, the liquid channel including a liquid interface, and at least one key pen next and parallel to the needle receiving portion of the liquid channel. In another example a key pen structure is provided. In yet another example an interface structure for receiving a separate key pen is provided.

Abstract: An interface for positive pressure respiratory therapy includes a mask assembly having a mask seal and a mask shell. The mask assembly is positioned lower than and exposes a bridge of the user's nose. The mask seal includes first and second portions on respective first and second sides of a nasal region that contact opposing sides of the user's nose. The first and second portions each include supports that help maintain a shape of the mask seal. A pair of covers can be supported relative to the mask assembly and adjacent a respective one of the first and second portions of the mask seal. The covers limit expansion of the first and second portions of the mask seal in response to pressurized air within the mask seal. The supports of the first and second portions can transfer load from the mask seal to the covers.

Abstract: Skin hydration is necessary to maintain the epidermal barrier, minimize adverse environmental influences, and reduce cell stress. Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically and cosmetically acceptable salts thereof, and compositions, methods, and uses that may be used for skin hydration. Also reported herein is a scalable method for synthesizing compounds of Formula (I). The compounds provided herein are responsible for improved skin penetration and/or retention and are therefore useful for the treatment and/or prevention of various diseases, disorders, or conditions to protect human skin.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: A printable liquid supply cartridge includes a printable liquid reservoir extending between a first side and a second side, and between a front end and a rear end. The front end includes a printable liquid outlet to receive a first fluid pen and a gas inlet, above the printable liquid outlet, to receive a second fluid pen. The front end also includes an interface support at the first side, the support having an I2C data interface that includes electrical connection pads exposed on an interior side of the support to face from the first side towards the second side, the electrical connection pads being arranged vertically and to make contact with the printer data interface at least partially inserted into the second portion.

Abstract: In one embodiment a sub-assembly of components is provided to assemble a print liquid supply container, the set including a reservoir and a support structure to form a print liquid supply container, the container having a first, second and third dimensions, the support structure to at least partially surround and support the reservoir and to provide stiffness to the container, at least in a folded and mounted condition, the reservoir including a bag to hold the print liquid, being at least partially flexible to collapse for print liquid to be withdrawn from the reservoir, the bag being configured to inhibit fluid exchange, and a neck that is relatively narrow with respect to the bag in a filled state, with an opening to output print liquid from the bag.

Abstract: Examples of a print liquid supply unit are described herein. In some examples, the print liquid supply unit includes an electrical interconnect. In some examples, the electrical interconnect is sealed in a supply joint from an outside of the supply unit to an inside of the supply unit. In some examples, the supply joint is welded to join housing components of the supply unit.

Abstract: A metered volume microfluidic device can include fluid flow microfluidics. The fluid flow microfluidics can include an inflow channel, a metered volume chamber positioned to receive working fluid from the inflow channel, a metered volume outflow channel positioned to receive and direct a metered volume of the working fluid when discharged from the metered volume chamber, and a capillary check valve. The capillary check valve can allow excess working fluid to exit the metered volume chamber when filling the metered volume chamber via the inflow channel. The capillary check valve can also prevent excess working fluid that has passed there through from being reintroduced into the metered volume chamber when the working fluid is discharged into the metered volume outflow channel.

Abstract: A print liquid supply interface structure is provided, to fluidically connect a fluid supply container to a receiving station, comprising a liquid channel having at least one liquid channel wall, the liquid channel including a liquid interface, and at least one key pen next and parallel to the needle receiving portion of the liquid channel. In another example a key pen structure is provided. In yet another example an interface structure for receiving a separate key pen is provided.

Abstract: Techniques are described herein for a wearable device that is configured to prevent unauthorized removal and to facilitate detection of unauthorized removal attempts or tampering with a band of the device. The wearable device includes one or more circuit systems, each of which is configured to conduct an electric current. Attempts to remove the device cause components of one or more of the circuit systems to break/fail, which disrupts the electric currents of the broken circuit systems. Such electric current disruptions are detected by the wearable device as evidence of an unauthorized removal attempt or tampering with the device band. The wearable device may include a hook-based latching mechanism or a rod-based latching mechanism. According to various embodiments, the wearable device is engaged with or disengaged from around a limb of a wearer responsive to an engage or disengage instruction from an authorized user of a client device.

Abstract: A print liquid supply apparatus or interface structure to be connected to a print system comprises a liquid channel, liquid interface and integrated circuit contact pads.