Abstract: A method of data replication from a first data storage device to a second data storage device. The method may include generating, at the first data storage device, at spaced time intervals, a plurality of snapshots for a logical data volume of the first data storage device, the logical data volume being an abstraction of data blocks from one or more physical storage devices, each snapshot identifying changes of data for at least a portion of the logical data volume since a most previous snapshot. Also at the first data storage device, the method includes generating a delta volume, the delta volume indicating changes in the data of at least a portion of the logical data volume between two non-consecutive snapshots. The method further involves replicating the delta volume to the second data storage device, and replicating the changes to the data indicated therein at the second data storage device.

Abstract: The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein W, X, n, s, t, and Ra are as described herein. The present invention relates generally to selective inhibitors of histone deacetylase and to methods of making and using them.

Abstract: The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention further relates to compounds of Formula I: F1—X1-L1-X2—P1—X3-G1??(Formula I) The invention relates to the treatment of diseases or disorders mediated by ARID1A (BAF250A).

Abstract: A system and method for an event marketplace. The system comprises a first interface for communicating with a plurality of user devices; a second interface for communicating with a plurality of systems of service providers; a progressive accuracy module for at least iteratively computing a set of total cost estimations of the event based in part on an event specification and information retrieved from one or more of the plurality of systems of service providers; and a cost optimizer for providing at least an optimal set of service providers matching the event specification, wherein the optimal set of service providers is ranked by their total cost estimations, the total cost estimation is a function of at least a proposal for a respective service.

Abstract: Described herein are compositions, methods and/or kits for determining the likelihood of a pregnant subject delivering at term, or developing a disorder associated with pregnancy. These compositions, methods and/or kits feature the measurement of the chemotactic activity of peripheral leukocytes, the measurement of ccl2 mRNA expression or the measurement of Fp or Otr protein expression.

Abstract: A method for dynamically calculating a reimbursement rate for vehicle usage including accessing expected cost factors that include a plurality of specific expected costs, deriving a geographically specific regional baseline CPM reimbursement rate that includes the expected cost factors; accessing a geopoint trip record comprised of a sequence of geopoints that include generated cost factors including a plurality of specific generated costs for the driven vehicle, individually comparing generated cost factors with associated expected cost factors to determine if the generated cost factors are greater than, less than, or equal to the expected cost factors, generating a positive cost allotment for each generated cost factor that is greater than the associated expected cost factor, generating a negative cost allotment for each generated cost factor that is less than the associated expected cost factor, and deriving a dynamic CPM reimbursement rate by adjusting the geographically specific regional baseline CPM rei

Abstract: The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention further relates to compounds of Formula I: F1-X1-L1-X2-P1-X3-G1??(Formula I) The invention relates to the treatment of diseases or disorders mediated by ARID1A (BAF250A).

Abstract: The present disclosure relates generally to a method and system for creating, replicating, and providing access to virtual snapshots of a disk storage block of a disk storage system or subsystem. In one embodiment, the present disclosure relates to a virtual snapshot accessible to local users of a local data storage device. The virtual snapshot may direct local users to a snapshot stored on computer-readable storage medium at a remote data storage site, but give the appearance as if data of the corresponding snapshot is stored locally. The virtual snapshot is replaced by replication of the snapshot from the remote data storage site to the local data storage device. Each snapshot may relate to data of a logical data volume, the logical data volume being an abstraction of data blocks from one or more physical storage devices.

Abstract: One variation of a method for controlling a reprogrammable payment card includes: at the payment card, establishing a wireless connection with a mobile computing device; receiving, over the wireless connection, a first magnetic sequence command corresponding to a first payment method, a first digital transaction credential corresponding to the first payment method, and a second magnetic sequence command corresponding to a second payment method; initiating a first mode; in the first mode, arming a controller within the payment card to drive a magnetic stripe emulator within the payment card according to the first magnetic sequence command; in the first mode, activating an integrated circuit within the payment card to broadcast the first digital transaction credential; and in the first mode, disabling operation of the magnetic stripe emulator and the integrated circuit in response to failure of a wireless connection with the mobile computing device.

Abstract: The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.

Abstract: A closure device may include a backing and a closure strip removably provided on the backing, wherein the closure strip includes a permanent adhesive on a back face thereof adapted to affix the closure strip to a package, wherein a breakout portion of the backing is configured to separate from the backing and remain adhered to the closure strip when the closure strip is removed therefrom. A product package may include a carton having a flap movable between an open position and a closed position, and a closure device affixed to a portion of the flap and a separate portion of the carton when the flap is in the closed position, wherein a first portion of the closure device is removable from the separate portion of the carton while the first portion remains attached to the portion of the flap.

Abstract: Methods of preparing polymeric webs include hot melt blending of thermoplastic resins and processing aids. The process aids include hindered amine N-substituted succinimide oligomers. The webs prepared from the blends may be in the form of films or non-woven fibrous webs. Non-woven microfiber webs are useful as filtration media. Among the polymeric webs produced are electret webs. The processing aids also function as charge-enhancing additives for the electret webs.

Abstract: The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention further relates to compounds of Formula I: F1-X1-L1-X2-P1-X3-G1??(Formula I) The invention relates to the treatment of diseases or disorders mediated by ARID1A (BAF250A).

Abstract: The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein W, X, n, s, t, and Ra are as described herein. The present invention relates generally to selective inhibitors of histone deacetylase and to methods of making and using them.

Abstract: A method of data replication from a first data storage device to a second data storage device. The method may include generating, at the first data storage device, at spaced time intervals, a plurality of snapshots for a logical data volume of the first data storage device, the logical data volume being an abstraction of data blocks from one or more physical storage devices, each snapshot identifying changes of data for at least a portion of the logical data volume since a most previous snapshot. Also at the first data storage device, the method includes generating a delta volume, the delta volume indicating changes in the data of at least a portion of the logical data volume between two non-consecutive snapshots. The method further involves replicating the delta volume to the second data storage device, and replicating the changes to the data indicated therein at the second data storage device.

Abstract: A method of data replication from a first data storage device to a second data storage device. The method may include generating, at the first data storage device, at spaced time intervals, a plurality of snapshots for a logical data volume of the first data storage device, the logical data volume being an abstraction of data blocks from one or more physical storage devices, each snapshot identifying changes of data for at least a portion of the logical data volume since a most previous snapshot. Also at the first data storage device, the method includes generating a delta volume, the delta volume indicating changes in the data of at least a portion of the logical data volume between two non-consecutive snapshots. The method further involves replicating the delta volume to the second data storage device, and replicating the changes to the data indicated therein at the second data storage device.

Abstract: The present disclosure relates generally to a method and system for creating, replicating, and providing access to virtual snapshots of a disk storage block of a disk storage system or subsystem. In one embodiment, the present disclosure relates to a virtual snapshot accessible to local users of a local data storage device. The virtual snapshot may direct local users to a snapshot stored on computer-readable storage medium at a remote data storage site, but give the appearance as if data of the corresponding snapshot is stored locally. The virtual snapshot is replaced by replication of the snapshot from the remote data storage site to the local data storage device. Each snapshot may relate to data of a logical data volume, the logical data volume being an abstraction of data blocks from one or more physical storage devices.

Abstract: The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.

Abstract: The present disclosure relates generally to a method and system for creating, replicating, and providing access to virtual snapshots of a disk storage block of a disk storage system or subsystem. In one embodiment, the present disclosure relates to a virtual snapshot accessible to local users of a local data storage device. The virtual snapshot may direct local users to a snapshot stored on computer-readable storage medium at a remote data storage site, but give the appearance as if data of the corresponding snapshot is stored locally. The virtual snapshot is replaced by replication of the snapshot from the remote data storage site to the local data storage device. Each snapshot may relate to data of a logical data volume, the logical data volume being an abstraction of data blocks from one or more physical storage devices.

Abstract: One variation of a method for controlling a reprogrammable payment card includes: at the payment card, establishing a wireless connection with a mobile computing device; receiving, over the wireless connection, a first magnetic sequence command corresponding to a first payment method, a first digital transaction credential corresponding to the first payment method, and a second magnetic sequence command corresponding to a second payment method; initiating a first mode; in the first mode, arming a controller within the payment card to drive a magnetic stripe emulator within the payment card according to the first magnetic sequence command; in the first mode, activating an integrated circuit within the payment card to broadcast the first digital transaction credential; and in the first mode, disabling operation of the magnetic stripe emulator and the integrated circuit in response to failure of a wireless connection with the mobile computing device.