Abstract: Disclosed are halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections. Such viral infections can include tongaviridae, bunyaviridae, arenaviridae, coronaviridae, flaviviridae, picornaviridae, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infections.

Abstract: The present invention relates to therapeutic ADCs comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. The ADC may be administered at a dosage of between 4 mg/kg and 18 mg/kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg/kg, most preferably 8 to 10 mg/kg. When administered at specified dosages and schedules, the ADC can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Preferably, the ADC is administered in combination with one or more other therapeutic agents, such as a PARP inhibitor, a microtubule inhibitor, a Bruton kinase inhibitor or a PI3K inhibitor. Most preferably, the ADC is of use for treating a Trop-2 expressing cancer, such as metastatic urothelial cancer.

Abstract: A rodent trap adapted to insert through a wall surface, in some embodiments into an interior, inaccessible void, the rodent trap comprising an elongated tubular component having an open distal end and an open proximal end, the open proximal end connected to a vacuum and flexible arm, the rodent trap operable to suck a rodent entering the elongated tubular component into the vacuum.

Abstract: The disclosure features compositions and methods that are useful for the treatment of cancer (e.g., gastrointestinal, colorectal cancers) featuring creatine transporter inhibitors (e.g., ?-Guanidinopropionic acid) in combination with a KRAS inhibitor or another chemotherapeutic agent (e.g., leucovorin (folinic acid-FOL), 5-fluorouracil (F), and irinotecan hydrochloride (IRI), and/or bevacizumab).

Abstract: A bait station for a rodent trap, the bait station adapted to prevent flipping of the rodent trap when activated, the bait station comprises an elongated protuberance affixed to a top surface of a base place, the elongated protuberance comprising a mounting camera oriented to film the rodent trap and begin filming when a proximity sensor is activated in some embodiments.

Abstract: Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

Abstract: A filter assembly includes a grate portion having a plurality of drain passages therein. A check valve portion includes a first end connected to the grate portion and a filter portion is connected to a second end of the check valve portion. The grate portion, the check valve portion and the filter portion are disposed in a hole in a concrete structure.

Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating primary liver cancers such as hepatocellular carcinoma (HCC) and intra-hepatic cholangiocarcinoma (ICC) comprising administering TLR9 agonists to the liver.

Abstract: This invention relates to compositions and methods for improving plant health, wherein a plant is heterologously disposed to one or more endophytes, or derived from a plant element heterologously disposed to one or more endophytes.

Abstract: A showerhead assembly is provided which includes a showerhead having a faceplate with an inner ring of nozzles and an outer ring of nozzles. Each nozzle of the outer ring points radially inward and with the same angle in a first direction tangential to the outer ring. Further, each nozzle of the inner ring points radially inward and with the same angle in a second direction tangential to the outer ring. Preferably, the outer ring nozzles point radially inward the same angle as the inner ring nozzles, but the outer ring nozzles point tangentially in the opposite directions as the inner ring. The nozzles are configured to emit non-intersecting narrow streams of water. The second spray is concentrically nested within the first spray and, collectively, the sprays produce a hyperboloid shape having a woven or lattice-like pattern.

Abstract: A machine for processing meat includes a motor with a shaft driven by the motor and a receptacle for a meat piece to be processed. The receptacle is open toward the driven shaft so that a part of the meat piece held in the receptacle is fed by an auger arranged in sections on the driven shaft toward a set of blades. The set of blades has a perforated disk arranged essentially perpendicular to the rotational axis of the driven shaft and a blade is arranged on a blade pin and is rotatable with this blade pin in a plane essentially parallel to the perforated disk. The blade pin is arranged on the driven shaft such that rotation of the driven shaft is transferred to the blade pin, so that the blade rotates.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: An end effector assembly of an ultrasonic surgical instrument includes an ultrasonic blade configured to mechanically couple to an ultrasonic transducer configured to transmit ultrasonic vibration energy to the ultrasonic blade and a jaw member movable relative to the ultrasonic blade from a spaced-apart position to an approximated position for clamping tissue therebetween. The jaw member includes a structural body and a jaw liner engaged with the structural body. The jaw liner defines a tissue contacting surface positioned to oppose the ultrasonic blade in the approximated position, and includes a wear indicator disposed within the jaw liner and configured to provide an alert indicating that the jaw liner is worn beyond a pre-determined threshold.

Abstract: A method of manufacturing a fibrous water soluble product having particles, including: a) providing a first continuous water soluble fibrous substrate including a first side and moving in a first direction, b) providing a discretizing unit including one or more pockets comprising an opening; c) providing a continuous feed of first particles to at least one of the one or more pockets of the discretizing unit through the pocket opening at least partially filling the at least one of the one or more pockets, d) delivering the first particles from the pocket through the opening onto a portion of the first side of the first continuous water soluble fibrous substrate, and e) at least partially covering the first side of the first continuous water soluble fibrous substrate.

Abstract: A method captures radiographic images of a patient using a common geometric relationship relative to an x-ray source, the patient and a digital detector. Change in the patient's health is assessed based on determined changes in the radiographic images of the patient. A time to capture a next radiographic image of the patient is automatically scheduled using the common geometric relationship.

Abstract: An arm assembly with an arm locking system is described. The arm assembly can include a base to position the arm on a support structure, an extension arm, a height adjustable lift arm, and a head assembly adapted to receive an electronic display. The extension arm can be rotatably coupled to the base at a first joint, the lift arm can be rotatably coupled to the extension arm at a second joint, and the head assembly can be rotatably coupled to the lift arm at a third joint. The arm locking system can include a first lock, a second lock, and a third lock engageable to selectively prevent movement about the first joint, the second joint, and the third joint, respectively. The arm locking system can also include a fourth lock engageable to selectively prevent the height adjustment of the lift arm.

Abstract: An example method includes capturing, via an x-ray machine, a plurality of x-ray images of a patient covering a number of different anatomy of the patient in any order, using a machine learning algorithm to process the plurality of x-ray images for identification of an anatomy in respective x-ray images of the plurality of x-ray images, associating a label with each of the plurality of x-ray images based on the identification of the anatomy, positioning each of the plurality of x-ray images upright based on a preset coordinate scheme for the anatomy, arranging the plurality of x-ray images into a predetermined order based on the species of the patient, and generating and outputting a data file including the plurality of x-ray images in the predetermined order, positioned upright, and labeled.

Abstract: Systems and methods for adding a functional layer to a lens having a plurality of microlenses for inhibition of ametropia. The lens may include defocus incorporated multiple segments (DIMS) having a plurality of microlenses or lenslets producing refraction areas with different refraction forces. Injection molding may be utilized to add a functional layer to such a DIMS lens having a plurality of microlenses or lenslets. The functional layer may add a functional utility to the lens, including but not limited to photochromic functionality, polarization functionality, and the like.

Abstract: A blood filtration system can be used with an external infusion pump and can include, among other things, a withdrawal line, an infusion (return) line, a filter coupled between the withdrawal line and the infusion line, a controller, and a withdrawal pressure sensor and/or an infusion pressure sensor. The withdrawal pressure sensor can sense a withdrawal pressure signal indicative of a pressure in the withdrawal line. The infusion pressure sensor can be coupled to the infusion line to sense an infusion pressure signal indicative of a pressure in the infusion line. In various embodiments, the controller can detect an operational state of the external infusion pump by analyzing at least the withdrawal pressure signal and/or the infusion pressure signal.

Abstract: An automated bioprocess solution preparation apparatus includes a first mixing chamber containing at least one ingredient for a bioprocess solution, a first port and a second port for a fluid to enter the mixing chamber, and a third port for a liquid bioprocess solution to exit the mixing chamber. The apparatus further includes an array of tubing for fluid flow within the apparatus, a sensor arranged to measure a property of the liquid bioprocess solution exiting the mixing chamber, a first valve associated with the first port, and a second valve associated with the second port. When the property meets or exceeds a threshold value, the apparatus is operable to perform at least one of: closing the first valve to block the fluid from entering the mixing chamber through the first port, and opening the second valve for the fluid to enter the mixing chamber through the second port.