Patents by Inventor David P. Jacobus

David P. Jacobus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100136125
    Abstract: Methods are disclosed for treating patients suffering from inflammatory bowel disease, including ulcerative colitis or Crohn's disease, by administering an oral or enema dosage form containing at least one aminosalicylate active ingredient. Granular dosage forms and kits are also disclosed.
    Type: Application
    Filed: December 26, 2007
    Publication date: June 3, 2010
    Applicant: Jacobus Pharmaceutical Company, Inc.
    Inventors: David P. Jacobus, Guy Alan Schiehser, Kathy Lynne Ales, Laura Ransom Jacobus
  • Patent number: 7563792
    Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: July 21, 2009
    Assignee: Jacobus Pharmaceutical Company, Inc.
    Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
  • Publication number: 20080176852
    Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.
    Type: Application
    Filed: June 27, 2007
    Publication date: July 24, 2008
    Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
  • Patent number: 7256218
    Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: August 14, 2007
    Assignee: Jacobus Pharmaceutical Company, Inc.
    Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
  • Publication number: 20040116428
    Abstract: Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.
    Type: Application
    Filed: November 18, 2003
    Publication date: June 17, 2004
    Inventors: David P. Jacobus, Guy A. Schiehser, Hong-Ming Shieh, Norman P. Jensen, Jacek Terpinski
  • Patent number: 6693217
    Abstract: Compounds of the formulae are disclosed. A method of protecting subjects from infections caused by an organism of the group: Plasmodium sp. Mycobacterium sp., P. falciparum, and Pneumocystis carinii by administering to the subjects liable to infections, a prophylactically effective amount of a compound of the foregoing formulae; and a method of reducing the level of infection in subjects caused by the above-listed organism by administering to the subjects an infection reductively effective amount of a compound of the foregoing formulae are also disclosed.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: February 17, 2004
    Assignee: Jacobus Pharmaceutical Co., Inc.
    Inventors: David P. Jacobus, Norman P. Jensen
  • Publication number: 20030144361
    Abstract: Compounds of the formulae 1
    Type: Application
    Filed: January 30, 2003
    Publication date: July 31, 2003
    Applicant: Jacobus Pharmaceutical Co., Inc.
    Inventors: David P. Jacobus, Norman P. Jensen
  • Patent number: 6551614
    Abstract: Compounds of the formulae are disclosed. A method of protecting subjects from infections caused by an organism of the group: Plasmodium sp., Mycobacterium sp., P. falciparum, M. avium complex, M. tuberculosis, M. kanasii and Pneumocystis carinii by administering to the subjects liable to infections, a prophylactically effective amount of a compound of the foregoing formulae; and a method of reducing the level of infection in subjects caused by the above-listed organism by administering to the subjects an infection reductively effective amount of a compound of the foregoing formulae are also disclosed.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: April 22, 2003
    Assignee: Jacobus Pharmaceutical Co., Inc.
    Inventors: David P. Jacobus, Norman P. Jensen
  • Publication number: 20030040544
    Abstract: Compounds of the formulae 1
    Type: Application
    Filed: March 14, 2001
    Publication date: February 27, 2003
    Inventors: David P. Jacobus, Norman P. Jensen
  • Patent number: 5322858
    Abstract: There are provided compounds of the formula ##STR1## wherein R.sup.1 is a substituted or unsubstituted divalent aliphatic group of 1 to 16 carbon atoms; wherein the substituents are mono or poly and are selected from the group consisting of lower alkyl, aryl and arlkyl, R.sup.3 is selected from the group consisting of same group of values as R.sup.5, R.sup.5 is selected from the group consisting of substituted and unsubstituted alkyl of 1-10 carbon atoms, aryl, cycloalkyl and heterocycloalkyl of 3-8 carbon atoms, wherein the substituents are mono or poly and are selected from the group consisting of lower alkyl, cycloalkyl of 3-8 carbon atoms, lower alkenyl, lower alkynyl, nitro, lower alkoxy, lower alkoxycarbonyl, phenyl loweralkyl, phenyl, mono and polyhalophenyl, phenoxy, mono and polyhalophenoxy, R.sup.6 and R.sup.7 may be the same or different and are hydrogen, alkanoyl or alkoxyalkanoyl, R.sup.7 may also have the same value as R.sup.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: June 21, 1994
    Assignee: Jacobus Pharmaceutical Co. Inc.
    Inventors: Craig Canfield, David P. Jacobus, Neil J. Lewis
  • Patent number: 4338334
    Abstract: The invention relates to 1-[4-(4-sulfanilyl)phenyl] urea and derivatives thereof in pharmaceutical compositions and in methods of treating rheumatoid arthritis and immune complex diseases such as dermatitis herpetiformis.
    Type: Grant
    Filed: February 29, 1980
    Date of Patent: July 6, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Norman P. Jensen, David P. Jacobus, Howard Jones
  • Patent number: 4237116
    Abstract: Combinations of thiopeptin and rumensin are shown to synergistically increase the feed efficiency of ruminant animals. The combination is orally administered to ruminant animals in the feed of the ruminanat or in an orally administered unit dosage form. The combination of thiopeptin and rumensin has a greater effect than the control animals given no medication, and greater than animals given either drug alone.
    Type: Grant
    Filed: April 19, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: James Gillin, David P. Jacobus
  • Patent number: 4069321
    Abstract: Novel cholecalciferol and dihydrotachysterol.sub.3 derivatives produced against metabolic conversions at the 25-position, their preparation, pharmaceutical compositions, methods of treating steroid-induced osteoporosis, senile osteoporosis and secondary hyperparathyroidism, especially that induced by an insufficient amount of calcium in relationship to the amount of phosphate, novel intermediates and their preparation are disclosed.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: January 17, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Howard Jones, Shu Shu Yang, David P. Jacobus
  • Patent number: 4060639
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and dicyclohexyl-, dicyclohexenyl- and cyclohexylcyclohexenyl-alkyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 29, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Patent number: 4058625
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines, their acid addition salts, and mixtures thereof are useful as antimicrobial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Patent number: 4058624
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and diphenyl and loweralkyl substituted diphenyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Patent number: 4046897
    Abstract: 5-Mercaptopyridoxine C.sub.1-4 alkane sulfonates, particularly the ethane-1,2-disulfonate, is a superior pharmaceutically acceptable form of the previously preferred 5-mercaptopyridoxine hydrochloride and hydrobromide.
    Type: Grant
    Filed: March 15, 1976
    Date of Patent: September 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Conrad P. Dorn, Howard Jones, David P. Jacobus