Patents by Inventor David Piwnica-Worms

David Piwnica-Worms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imaging regulated protein-protein interactions in cells and living animals by enhanced luciferase protein fragment complementation
    Publication number: 20050144661
    Abstract: An enhanced firefly luciferase protein fragment complementation assay method is described that produces a robust and broadly applicable bioluminescence signal and demonstrates both modification-independent and phosphorylation-dependent protein interactions in intact living human cells and animals useful as a diagnostic and testing tool in living biologic systems in research and in assays.
    Type: Application
    Filed: August 6, 2004
    Publication date: June 30, 2005
    Inventors: David Piwnica-Worms, Kathryn Luker, Gary Luker
  • Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
    Publication number: 20030219375
    Abstract: Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.
    Type: Application
    Filed: February 18, 2003
    Publication date: November 27, 2003
    Inventor: David Piwnica-Worms
  • Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
    Publication number: 20030219378
    Abstract: Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.
    Type: Application
    Filed: February 25, 2003
    Publication date: November 27, 2003
    Inventor: David Piwnica-Worms
  • Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
    Patent number: 6589503
    Abstract: Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: July 8, 2003
    Assignee: Washington University
    Inventor: David Piwnica-Worms
  • Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
    Patent number: 6348185
    Abstract: Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: February 19, 2002
    Assignee: Washington University School of Medicine
    Inventor: David Piwnica-Worms