Patents by Inventor David Pot
David Pot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20070243176Abstract: This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.Type: ApplicationFiled: July 7, 2003Publication date: October 18, 2007Inventors: Jaime Escobedo, Pablo Garcia, Julie Sudduth-Klinger, Christoph Reinhard, Filippo Randazzo, George Lamson, Elizabeth Scott, Guozhong Zhang, Altaf Kassam, David Pot, Radoje Drmanac, Ivan Labat, Birgit Stache-Crain
-
Patent number: 7122373Abstract: This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.Type: GrantFiled: May 13, 1999Date of Patent: October 17, 2006Assignee: Nuvelo, Inc.Inventors: Lewis T. Williams, Jaime Escobedo, Michael A. Innis, Pablo Dominguez Garcia, Julie Sudduth-Klinger, Christoph Reinhard, Klaus Giese, Filippo Randazzo, Giulia C. Kennedy, David Pot, Altaf Kassam, George Lamson, Radoje Drmanac, Radomir Crkvenjakov, Mark Dickson, Snezana Drmanac, Ivan Labat, Dena Leshkowitz, David Kita, Veronica Garcia, Lee William Jones, Birgit Stache-Crain
-
Patent number: 6964868Abstract: This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.Type: GrantFiled: January 28, 1999Date of Patent: November 15, 2005Assignee: Nuvelo, Inc.Inventors: Lewis T. Williams, Jaime Escobedo, Michael A. Innis, Pablo Dominguez Garcia, Julie Sudduth-Klinger, Christoph Reinhard, Klaus Giese, Filippo Randazzo, Giulia C. Kennedy, David Pot, Altaf Kassam, George Lamson, Radoje Drmanac, Radomir Crkvenjakov, Mark Dickson, Snezana Drmanac, Ivan Labat, Dena Leshkowitz, David Kita, Veronica Garcia, Lee William Jones, Birgit Stache-Crain
-
Publication number: 20050227917Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.Type: ApplicationFiled: February 12, 2004Publication date: October 13, 2005Inventors: Lewis Williams, Jaime Escobedo, Michael Innis, Pablo Garcia, Julie Sudduth-Klinger, Christoph Reinhard, Klaus Giese, Filippo Randazzo, Giulia Kennedy, David Pot, Altaf Kassam, George Lamson, Zhijun He, Elizabeth Scott, Guozhong Zhang, Theresa May, Doreen Sakamoto, Radoje Drmanac, Radomir Crkvenjakov, Mark Dickson, Snezana Drmanac, Ivan Labat, Dena Leshkowitz, David Kita, Veronica Garcia, Lee Jones, Birgit Stache-Crain
-
Publication number: 20040086913Abstract: This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.Type: ApplicationFiled: June 26, 2003Publication date: May 6, 2004Inventors: Lewis T. Williams, Jaime Escobedo, Michael A. Innis, Pablo Dominguez Garcia, Julie Sudduth Klinger, Christoph Reinhard, Zhijun He, Filippo Randazzo, Giulia C. Kennedy, David Pot, Altaf Kassam, George Lamson, Radjoe Drmanac, Mark Dickson, Ivan Labat, Lee William Jones, Birgit Stache-Crain
-
Publication number: 20030166217Abstract: A human gene encoding a novel cyclin-dependent kinase termed hPFTAIRE and its expression products can be used to provide reagents and methods for detecting migrating or metastasizing cells. Compositions and methods for treating proliferative disorders and neoplasia are also provided.Type: ApplicationFiled: May 22, 2002Publication date: September 4, 2003Applicant: Chiron CorporationInventors: Christoph Reinhard, David Pot, Altaf Kassam, Tasha Marenbach, Lewis T. Williams
-
Publication number: 20030113869Abstract: This invention relates to human fibroblast growth factor (FGF 98), and to variants thereof and to polynucleotides encoding FGF 98. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies.Type: ApplicationFiled: April 17, 2001Publication date: June 19, 2003Inventors: Hui Cen, Pablo D. Garcia, Uta Grieshammer, Altaf Kassam, Pauline P. Lee, David Pot, Denis Gospodarowicz, Kathleen Martin
-
Publication number: 20030065156Abstract: This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polymucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.Type: ApplicationFiled: February 15, 2002Publication date: April 3, 2003Inventors: Lewis T. Williams, Jaime Escobedo, Michael A. Innis, Pablo Dominguez Garcia, Julie Sudduth-Klinger, Christoph Reinhard, Klause Giese, Filippo Randazzo, Giulia C. Kennedy, David Pot, Atlaf Kassam, George Lamson, Radoje Drmanac, Radomir Crkvenjakov, Mark Dickson, Snezana Drmanac, Ivan Labat, Dena Leshkowitz, David Kita, Veronica Garcia, Lee William Jones, Birgit Stache-Crain
-
Publication number: 20030044783Abstract: This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.Type: ApplicationFiled: March 9, 2001Publication date: March 6, 2003Inventors: Lewis T. Williams, Jaime Escobedo, Michael A. Innis, Pablo Dominguez Garcia, Julie Sudduth-Klinger, Christoph Reinhard, Filippo Randazzo, Giulia C. Kennedy, David Pot, Altaf Kassam, George Lamson, Radjoe Drmanac, Mark Dickson, Ivan Labat, Lee William Jones, Birgit Stache-Crain
-
Patent number: 6492112Abstract: A human gene encoding a novel mitogen-activated (MAP) kinase kinase, MKK7, provides methods and reagents for treating a variety of MKK7-mediated disorders, such as ischemic heart disease, kidney failure, oxidative liver damage, respiratory distress syndrome, heat and radiation burns, septic shock, autoimmune disorders, and inflammatory diseases. MKK7 reagents can also be used to induce or prevent apoptosis.Type: GrantFiled: December 7, 1998Date of Patent: December 10, 2002Assignee: Chiron CorporationInventors: Christoph Reinhard, Altaf Kassam, David Pot
-
Patent number: 6472197Abstract: The present invention generally relates to novel GRB2 associating proteins and nucleic acids which encode these protein. In particular, these novel proteins possess inositol polyphosphate 5-phosphatase and phosphatidylinositol 5-phosphatase activities, important in growth factor mediated signal transduction. As such, the proteins, nucleic acids encoding the proteins, cells capable of expressing these nucleic acids and antibodies specific for these proteins will find a variety of uses in a variety of screening, therapeutic and other applications.Type: GrantFiled: October 1, 2001Date of Patent: October 29, 2002Assignees: The Regents of the University of California, Washington UniversityInventors: David A. Pot, Lewis T. Williams, Anne Bennett Jefferson, Philip W. Majerus
-
Publication number: 20020150567Abstract: The present invention generally relates to novel GRB2 associating proteins and nucleic acids which encode these protein. In particular, these novel proteins possess inositol polyphosphate 5-phosphatase and phosphatidylinositol 5-phosphatase activities, important in growth factor mediated signal transduction. As such, the proteins, nucleic acids encoding the proteins, cells capable of expressing these nucleic acids and antibodies specific for these proteins will find a variety of uses in a variety of screening, therapeutic and other applications.Type: ApplicationFiled: October 1, 2001Publication date: October 17, 2002Applicant: The Regents of the University of CaliforniaInventors: David A. Pot, Lewis T. Williams, Anne Bennett Jefferson, Philip W. Majerus
-
Patent number: 6432668Abstract: A human gene encoding a novel cyclin-dependent kinase termed hPFTAIRE and its expression products can be used to provide reagents and methods for detecting migrating or metastasizing cells. Compositions and methods for treating proliferative disorders and neoplasia are also provided.Type: GrantFiled: December 7, 1998Date of Patent: August 13, 2002Assignee: Chiron CorporationInventors: Christoph Reinhard, David Pot, Altaf Kassam, Tasha Marenbach, Lewis T. Williams
-
Publication number: 20020076735Abstract: The invention provides materials and methods for determining the metastatic potential of a cell and for identifying cancerous cells by determining the presence or absence of one or more expression products of at least one gene that is differentially expressed between normal cells, nonmetastatic cells, cells of low metastatic potential, and cells of high metastatic potential.Type: ApplicationFiled: May 10, 2001Publication date: June 20, 2002Inventors: Lewis T. Williams, Jaime Escobedo, Michael A. Innis, Pablo Dominguez Garcia, Julie Sudduth-Klinger, Christoph Reinhard, Klaus Giese, Filippo Randazzo, Giulia C. Kennedy, David Pot, Altaf Kassam, George Lamson, Radoje Drmanac, Radomir Crkvenjakov, Mark Dickson, Snezana Drmanac, Ivan Labat, Dena Leshkowitz, David Kita, Veronica Garcia, Lee William Jones, Birgit Stache-Crain
-
Patent number: 6296848Abstract: The present invention generally relates to novel GRB2 associating proteins and nucleic acids which encode these protein. In particular, these novel proteins possess inositol polyphosphate 5-phosphatase and phosphatidylinositol 5-phosphatase activities, important in growth factor mediated signal transduction. As such, the proteins, nucleic acids encoding the proteins, cells capable of expressing these nucleic acids and antibodies specific for these proteins will find a variety of uses in a variety of screening, therapeutic and other applications.Type: GrantFiled: October 14, 1999Date of Patent: October 2, 2001Assignee: The Regents of the University of CaliforniaInventors: David A. Pot, Lewis T. Williams, Anne Bennett Jefferson, Philip W. Majerus
-
Patent number: 6090621Abstract: Novel polypeptides called signaling inositol polyphosphate 5-phosphatases are described called SIP-130, SIP-125, and SIP-N. SIP-130 is capable of binding to aPTB domain of SH2 and collagen containing protein (SHC). Also provided are polynucleotide sequences encoding the novel polypeptides, as well as vectors and host cells containing the polynucleotides. Further provided are modulators including agonists and antagonists of the novel polypeptides for use as therapeutics, including antibodies, polypeptides, small molecules, and polynucleotides and methods of using the therapeutics in treatment of diseases associated with abnormal cell growth. Methods of making the polypeptides, polynucleotides, vectors, host cells, antibodies, and small molecules are also provided. Gene delivery vehicles including SIP and SIP activity-modulating polynucleotides are described.Type: GrantFiled: November 19, 1998Date of Patent: July 18, 2000Assignee: Chiron CorporationInventors: W. Michael Kavanaugh, David Pot, Lewis T. Williams
-
Patent number: 6077701Abstract: A novel kinase has been identified which phosphorylates I.kappa.B. Reagents which inhibit this kinase can be used as therapeutic tools to inhibit inflammation. The kinase can also be used as a target for drug screening to identify anti-inflammatory compounds.Type: GrantFiled: December 29, 1998Date of Patent: June 20, 2000Assignee: Chiron CorporationInventors: Keting Chu, David Pot
-
Patent number: 6030834Abstract: A novel kinase has been identified which phosphorylates I.kappa.B. Reagents which inhibit this kinase can be used as therapeutic tools to inhibit inflammation. The kinase can also be used as a target for drug screening to identify anti-inflammatory compounds.Type: GrantFiled: December 18, 1998Date of Patent: February 29, 2000Assignee: Chiron CorporationInventors: Keting Chu, David Pot
-
Patent number: 6001354Abstract: The present invention generally relates to novel GRB2 associating proteins and nucleic acids which encode these protein. In particular, these novel proteins possess inositol polyphosphate 5-phosphatase and phosphatidylinositol 5-phosphatase activities, important in growth factor mediated signal transduction. As such, the proteins, nucleic acids encoding the proteins, cells capable of expressing these nucleic acids and antibodies specific for these proteins will find a variety of uses in a variety of screening, therapeutic and other applications.Type: GrantFiled: November 17, 1995Date of Patent: December 14, 1999Assignees: Washington University, The Regents of the University of CaliforniaInventors: David A. Pot, Lewis T. Williams, Anne Bennett Jefferson, Philip W. Majerus