Patents by Inventor David R. Blake

David R. Blake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11964988
    Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 23, 2024
    Assignee: ARRAY BIOPHARMA INC.
    Inventors: James F. Blake, Donghua Dai, Julia Haas, Yutong Jiang, Dean Kahn, Gabrielle R. Kolakowski, Elizabeth A. McFaddin, Megan L McKenney, Andrew T. Metcalf, David A. Moreno, Brett Prigaro, Ginelle A. Ramann, Li Ren, Shane M. Walls, Hailong Zhang
  • Publication number: 20240066029
    Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
    Type: Application
    Filed: June 27, 2023
    Publication date: February 29, 2024
    Inventors: Steven W. ANDREWS, Sean ARONOW, James F. Blake, Barbara J. BRANDHUBER, Adam COOK, Julia HAAS, Yutong JIANG, Gabrielle R. KOLAKOWSKI, Elizabeth A. MCFADDIN, Megan L. MCKENNEY, Oren T. MCNULTY, Andrew T. METCALF, David A. MORENO, Tony P. TANG, Li REN
  • Publication number: 20220256809
    Abstract: Inflatable balance equipment for training dogs that includes an inflatable pad in the general shape of a right rectangular prism with rounded edges and with an indentation in each of two opposite sides with each indentation spanning a height of the side it is in, and two handles unitarily using the same material as the inflatable pad with one handle positioned in each of the indentations. The inflatable pad can also include markings along either or both of the longitudinal or horizontal axis of the pad that can be used by a trainer to position the dog on the pad. A connecting device can be used to connect multiple pads together at the handles to create an array of pads.
    Type: Application
    Filed: January 31, 2022
    Publication date: August 18, 2022
    Applicant: Blue-9, LLC
    Inventors: David R. Blake, Jamie Jerusa Popper
  • Patent number: 9282819
    Abstract: A table configured to aid in the training of animals. The table can include legs that can be in multiple positions, one of which allows the legs to be stored. Multiple of such tables and/or table tops can be stacked atop each other to alter the height of the table top and still be laterally stable between the tables and/or table tops. The tables can also include projections and recesses that enable lateral interlocking of the tables to form a larger table top surface. Each table can be designed to be lightweight, portable, rigid, and stable for use as an animal training aid.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: March 15, 2016
    Assignee: Blue-9, LLC
    Inventor: David R. Blake
  • Publication number: 20160015177
    Abstract: A table configured to aid in the training of animals. The table can include legs that can be in multiple positions, one of which allows the legs to be stored. Multiple of such tables and/or table tops can be stacked atop each other to alter the height of the table top and still be laterally stable between the tables and/or table tops. The tables can also include projections and recesses that enable lateral interlocking of the tables to form a larger table top surface. Each table can be designed to be lightweight, portable, rigid, and stable for use as an animal training aid.
    Type: Application
    Filed: July 18, 2014
    Publication date: January 21, 2016
    Inventor: David R. Blake
  • Patent number: 8690427
    Abstract: Methods for inspecting contents of a container. High-energy penetrating radiation collimated into a fan beam illuminates an inspected container from one side, while a plurality of detector plates are disposed on the opposite side of the container. Each detector plate has a plurality of detector modules, each of which, in turn, is disposed on a remotely activated alignment and has multiple detector elements. A controller governs the orientation of each of the plurality of detector plates based at least on the detector signal generated by its detector elements such that each detector element of each detector module of each detector plate may be aligned to within a specified fraction of the transverse dimension of the fan beam as measured at the exit slot.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: April 8, 2014
    Assignee: American Science and Engineering, Inc.
    Inventors: Richard Mastronardi, Jeffrey M. Denker, Peter Rothschild, Dan-Cristian Dinca, Aaron D. Pailes, David R. Blake, Domenic Martignetti
  • Publication number: 20130230140
    Abstract: Methods for inspecting contents of a container. High-energy penetrating radiation collimated into a fan beam illuminates an inspected container from one side, while a plurality of detector plates are disposed on the opposite side of the container. Each detector plate has a plurality of detector modules, each of which, in turn, is disposed on a remotely activated alignment and has multiple detector elements. A controller governs the orientation of each of the plurality of detector plates based at least on the detector signal generated by its detector elements such that each detector element of each detector module of each detector plate may be aligned to within a specified fraction of the transverse dimension of the fan beam as measured at the exit slot.
    Type: Application
    Filed: April 18, 2013
    Publication date: September 5, 2013
    Applicant: American Science and Engineering, Inc.
    Inventors: Richard Mastronardi, Jeffrey M. Denker, Peter Rothschild, Dan-Cristian Dinca, Aaron D. Pailes, David R. Blake, Domenic Martignetti
  • Patent number: 8439565
    Abstract: A scanning system and methods for inspecting contents of a container. High-energy penetrating radiation collimated into a fan beam illuminates an inspected container from one side, while a plurality of detector plates are disposed on the opposite side of the container. Each detector plate has a plurality of detector modules, each of which, in turn, is disposed on a remotely activated alignment and has multiple detector elements. A controller governs the orientation of each of the plurality of detector plates based at least on the detector signal generated by its detector elements such that each detector element of each detector module of each detector plate may be aligned to within a specified fraction of the transverse dimension of the fan beam as measured at the exit slot.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: May 14, 2013
    Assignee: American Science and Engineering, Inc.
    Inventors: Richard Mastronardi, Jeffrey M. Denker, Peter Rothschild, Dan-Cristian Dinca, Aaron D. Pailes, David R. Blake, Domenic Martignetti
  • Publication number: 20120093288
    Abstract: A scanning system and methods for inspecting contents of a container. High-energy penetrating radiation collimated into a fan beam illuminates an inspected container from one side, while a plurality of detector plates are disposed on the opposite side of the container. Each detector plate has a plurality of detector modules, each of which, in turn, is disposed on a remotely activated alignment and has multiple detector elements. A controller governs the orientation of each of the plurality of detector plates based at least on the detector signal generated by its detector elements such that each detector element of each detector module of each detector plate may be aligned to within a specified fraction of the transverse dimension of the fan beam as measured at the exit slot.
    Type: Application
    Filed: September 19, 2011
    Publication date: April 19, 2012
    Applicant: AMERICAN SCIENCE AND ENGINEERING, INC.
    Inventors: Richard Mastronardi, Jeffrey M. Denker, Peter Rothschild, Dan-Cristian Dinca, Aaron D. Pailes, David R. Blake, Domenic Martignetti
  • Patent number: 6812834
    Abstract: A reference sample for testing fire detectors and a method of testing utilizing the reference samples. The reference sample comprises a fused mixture of pellets of the plastics usually found in aircraft cargo holds, with a heating element embedded in the sample. The pellets are in a plurality of layers with the composition of each layer being homogeneous but the thicknesses and porosities of the layers differing from each other. When the heating element is energized the layers of pellets, which have previously been fused into porous masses, begin to smolder, thereby generating a smoky atmosphere that as nearly as possible simulates the atmosphere in an aircraft cargo hold when there is a fire in the hold. In addition, a flammable liquid can be poured onto the sample and ignited, simultaneously with the energization of the heating element, by a separate ignition source to provide a flaming fire atmosphere.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: November 2, 2004
    Assignee: The United States of America as represented by the Secretary of Transportation
    Inventors: Richard E. Lyon, David R. Blake
  • Publication number: 20030131649
    Abstract: A reference sample for testing fire detectors and a method of testing utilizing the reference samples. The reference sample comprises a fused mixture of pellets of the plastics usually found in aircraft cargo holds, with a heating element embedded in the sample. The pellets are in a plurality of layers with the composition of each layer being homogeneous but the thicknesses and porosities of the layers differing from each other. When the heating element is energized the layers of pellets, which have previously been fused into porous masses, begin to smolder, thereby generating a smoky atmosphere that as nearly as possible simulates the atmosphere in an aircraft cargo hold when there is a fire in the hold. In addition, a flammable liquid can be poured onto the sample and ignited, simultaneously with the energization of the heating element, by a separate ignition source to provide a flaming fire atmosphere.
    Type: Application
    Filed: January 17, 2002
    Publication date: July 17, 2003
    Inventors: Richard E. Lyon, David R. Blake
  • Patent number: 6220901
    Abstract: A terminal board assembly for an electric motor is described. The terminal board assembly is configured to mount inside an electric motor terminal or conduit box and includes a terminal board and a mounting bracket. The terminal board includes six terminal studs and three connecting bars extending between the terminal studs. Quick connect spade type connectors are coupled to the six terminal studs adjacent the bottom of the terminal board to facilitate quick and easy connection of the wire connection leads of an electric motor. The terminal studs and connecting bars permit a choice of “Y” or “Delta” voltage connections to the electric motor. The terminal board also includes a first and a second slot positioned at, and parallel to, opposing ends of the board. The mounting bracket includes a base portion and first and second side portions depending from opposing ends of the base portion.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: April 24, 2001
    Assignee: General Electric Company
    Inventors: L. Edwin Fisher, James A. Butcher, Marc D. Pape, David R. Blake
  • Patent number: 6062739
    Abstract: A fiber optic connector assembly for mating an optical fiber to a receptacle includes an adapter and a plug separably coupled to the adapter. The adapter has a first end coupled to the receptacle with a first surface of the adapter contacting a surface of a housing wall through which the receptacle projects. A sealing member is disposed between the first surface of the adapter and the surface of the housing wall. In one embodiment the sealing member includes an O-ring groove provided in the first surface of the adapter and an O-ring disposed in the O-ring groove. The plug has an external surface with an alignment band formed on the external surface thereof. A first end of the plug is separably coupled to the second end of the adapter and a second end of the plug is adapted to receive the optical fiber. The connector assembly further includes a locking mechanism to prevent the plug from separating from the adapter in response to a vibration force.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: May 16, 2000
    Assignee: Raytheon Company
    Inventors: David R. Blake, Brian D. Morrison, Randolph W. Holtgrefe
  • Patent number: 5714143
    Abstract: The present invention relates to the use of pharmaceutical preparations containing manganese superoxide dismutase in a low dose for treating diseases and conditions caused by free oxygen radicals.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: February 3, 1998
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: David R. Blake, Ewa J. Dowling, Christian Lillie, Andreas Zophel
  • Patent number: 5674887
    Abstract: The administration of a xanthine oxidase inhibitor is effective for the treatment or prevention of the excessive resorption of bone in conditions such as osteoporosis and the like.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: October 7, 1997
    Assignees: Eli Lilly and Company, London Hospital Medical College, St. George's Hospital Medical School
    Inventors: David R. Blake, Jill A. Panetta, Mone Zaidi
  • Patent number: 5436258
    Abstract: The administration of a xanthine oxidase inhibitor is effective for the treatment or prevention of the excessive resorption of bone in conditions such as osteoporosis and the like.
    Type: Grant
    Filed: September 9, 1992
    Date of Patent: July 25, 1995
    Assignees: Eli Lilly and Company, London Hospital Medical College, St. George's Hospital Medical School
    Inventors: David R. Blake, Jill A. Panetta, Mone Zaidi
  • Patent number: 5336248
    Abstract: The present invention relates to an apparatus for the treatment of or the inhibition of retinopathy of prematurity and to a method for treating or for inhibiting retinopathy of prematurity. The apparatus provided in accordance with the present invention includes a component or system for providing substantially only red light. Thus, light is provided having a wave band of approximately 612 nm or more. Furthermore, at least the patient's head is received in a device that limits the light which reaches the patient's eyes to the aforementioned red light. Thus, the patient is allowed to see substantially only red light.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: August 9, 1994
    Assignee: British Technology Group Ltd.
    Inventors: Peter A. Good, Christopher J. Morris, Andrew W. D. Claxson, David R. Blake
  • Patent number: 4397867
    Abstract: Rheumatoid arthritic and like diseases involving joint inflammation are treated by administering desferrioxamine in a therapeutically effective dosage over a prolonged period.
    Type: Grant
    Filed: June 15, 1982
    Date of Patent: August 9, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: David R. Blake
  • Patent number: 4239591
    Abstract: A non-laminated paper sheet product characterized by regions or islands of increased thickness, usually located in the center of the sheet for more economical use of the paper product and for conservation of wood pulp. The regions of increased thickness are formed by depositing or laying additional pulp stock onto a generally uniform thickness paper web in the web-forming area of a paper machine in either wet or dry methods of paper production. Continuous regions of increased thickness in the web can be formed by corresponding variations in the width of the web or by spraying the additional pulp onto the forming web. Islands of increased web thickness can be formed by periodically interrupting pulp stock depositing sprayheads disposed at spaced locations across the width of the forming web, with timing devices or web thickness sensors controlling the sprayheads.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: December 16, 1980
    Inventor: David R. Blake
  • Patent number: 4197706
    Abstract: A readily portable hydraulic power source for supplying hydraulic fluid pressure to emergency hydraulic tools is foot-operated such that the operator's hands are left free to use the hydraulic tools and both the tools and power source may be operated by a single person. The power source includes a generally planar base member, a hydraulic pump fixedly mounted at one end of the base member, a foot-engaging planar member in generally overlying relation to the base member, a hinge connecting ends of the base member and the planar member for movement of the planar member relative to the base, and a resilient spring between the base and planar members to urge the members pivotally apart upon release of pressure from the operator's foot. The operator's foot is retained by straps and a heel retaining portion attached to the planar member, with the heel portion having an arm operatively connected to a hydraulic piston of the pump.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: April 15, 1980
    Inventor: David R. Blake