Abstract: A tube coupling is shown, particularly but not exclusively intended for use in joining tubes which have medical and surgical uses. A coupling according to the invention may be used to connect an ostomy bag to a drainage tube, or to connect an incontinence urine collection device to a drainage tube, or to connect a drainage tube to a drainage bag, or a catheter to a drainage tube. A tube coupling has a male part and a female part. The former has a radially extending external peripheral rib near its free end. The female part is made in one piece and comprises a tubular shell of a relatively rigid plastics material provided with an annular internal recess. The recess has molded therein a hollow tubular member of a relatively soft plastics material. The female part has no loose parts to become detached, can be made inexpensively by a "two-shot" molding process, and provides extremely good security against leakage.