Patents by Inventor David Raab

David Raab has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD AND DEVICE FOR OPTIMIZING A NUCELOTIDE SEQUENCE FOR THE PURPOSE OF EXPRESSION IN A PROTEIN
    Publication number: 20130123483
    Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.
    Type: Application
    Filed: June 15, 2012
    Publication date: May 16, 2013
    Applicant: GENEART AG
    Inventors: DAVID RAAB, MARCUS GRAF, FRANK NOTKA, RALF WAGNER
  • Method and device for optimizing a nucleotide sequence for the purpose of expression of a protein
    Patent number: 8224578
    Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: July 17, 2012
    Assignee: Geneart AG
    Inventors: David Raab, Marcus Graf, Frank Notka, Ralf Wagner
  • METHOD AND SYSTEM FOR PROVIDING A CUSTOM BIOPOLYMER TO A CUSTOMER
    Publication number: 20120022966
    Abstract: The present invention relates to a method and a system for providing a customer biopolymer to a customer. The sequence of a customer biopolymer is transferred to a production control system of a biopolymer service provider, synthesized on a production machine of the service provider and delivered to the customer, wherein no human action is necessary to initiate or control the synthesis process.
    Type: Application
    Filed: July 29, 2011
    Publication date: January 26, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: David RAAB, Thomas Schoedl
  • Method for modulating gene expression by modifying the cpg content
    Publication number: 20090324546
    Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.
    Type: Application
    Filed: August 3, 2005
    Publication date: December 31, 2009
    Inventors: Frank D. Notka, Marcus Graf, Doris Leikam, Ralf Wagner, David Raab
  • Method and System for Providing a Customer Biopolymer to a Customer
    Publication number: 20090094042
    Abstract: The present invention relates to a method and a system for providing a customer biopolymer to a customer. The sequence of a customer biopolymer is transferred to a production control system of a biopolymer service provider, synthesized on a production machine of the service provider and delivered to the customer, wherein no human action is necessary to initiate or control the synthesis process.
    Type: Application
    Filed: October 9, 2007
    Publication date: April 9, 2009
    Applicant: Mr. Gene GmbH
    Inventors: David RAAB, Thomas Schoedl
  • Method and device for optimizing a nucleotide sequence for the purpose of expression of a protein
    Publication number: 20070141557
    Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.
    Type: Application
    Filed: December 23, 2003
    Publication date: June 21, 2007
    Inventors: David Raab, Marcus Graf, Frank Notka, Ralf Wagner