Abstract: Systems and methods for monitoring a subject for sleep apnea risk based on a bradycardia burden are disclosed. A sleep apnea monitoring system comprises a risk stratification circuit configured to detect bradycardia using cardiac information of the subject during a monitoring period, determine a bradycardia burden representing accumulated time or relative time of the subject being in the detected bradycardia over the monitoring period, and determine an apnea risk based on the bradycardia burden. An output unit can provide the apnea risk to a user, or to a process executed by an apnea detector to perform a confirmatory apnea detection.

Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.

Abstract: Optionally, a plurality of spacers 228 is arranged between the planar surface 120 of the interfacing arrangement 114 (or the top horizontal arm) and the seat arrangement 102, for permanently raising the seat arrangement 102 with respect to the interfacing arrangement 114. The spacers 228 can be implemented as rectangular or cylindrical solid blocks that can be fabricated from plastics materials, metals, metal alloys, polymers, ceramics, wood, composites and so forth. The spacers 228 can be fixed between the seat arrangement 102 and the top planar surface 120 of the top horizontal arm of the interfacing arrangement 114 such that height of the seat arrangement 102 relative to the footrest arrangement 116 is raised. For example, a plurality of metallic spacers is fixed between the seat arrangement 102 and the interface arrangement by a technician such as by welding the metallic spacers between the seat arrangement 102 and the interface arrangement.

Abstract: The present disclosure discloses methods for culturing stem cells in three-dimensional methods. Said method is either a spheroid-based method or a microcarrier-based method. The process as described herein leads to the expansion of the stem cells to obtain an expanded population of the stem cells, and a stem cell derived-conditioned medium. The present disclosure also discloses an expanded population of the stem cells, and a stem cell derived-conditioned medium obtained from the process as described herein. Further, an exosome preparation obtained from the stem cell derived-conditioned medium is also disclosed herein. The present disclosure also discloses a composition comprising an expanded population of the stem cells, or a stem cell derived-conditioned medium, or an exosome preparation, or combinations thereof. Methods of treatment using the composition as described herein is also disclosed in the present disclosure.

Abstract: There is disclosed a mobility aid device including a seat arrangement upon which a user sits when the mobility device aid is in operation, a main unit that supports the seat arrangement, and a wheel arrangement that supports the main unit on a floor surface. The mobility aid device is driven in operation from a motor arrangement included in at least one of the main unit and the wheel arrangement, wherein the mobility device aid is propelled forwards or backwards and turned by the motor arrangement. The wheel arrangement includes two wheels mounted at lateral sides of main unit, wherein the two wheels are mutually independently driven in operation by the motor arrangement. The mobility aid device is self-balancing using the two wheels by employing a control module that controls an electrical signal applied to the motor arrangement, and the wheels are contained within an area that is less than 120% of a seating area of the seat arrangement.

Abstract: The present disclosure provides a process for obtaining an expanded primed mesenchymal stem cell population. In the process, the MSCs are cultured in the culture medium comprising a corneal stromal stem cell derived-conditioned medium to obtain the expanded population of the primed mesenchymal stem cell population along with the mesenchymal stem cell derived-conditioned medium. Also, provided is a method of culturing the MSCs in 3D culture using a spheroid-based method or a microcarrier-based method, in order to obtain the expanded primed mesenchymal stem cell population. Further, an exosome preparation obtained from the expanded primed mesenchymal stem cell derived-conditioned medium is also disclosed herein. The present disclosure also discloses a composition comprising an expanded population of the primed mesenchymal stem cells, or a primed mesenchymal stem cell derived-conditioned medium, or an exosome preparation, or combinations thereof.