Patents by Inventor David Rollo
David Rollo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
Patent number: 10814013Abstract: Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.Type: GrantFiled: July 31, 2012Date of Patent: October 27, 2020Assignees: The Board of Regents of the University of Texas System, Cell>Point, LLCInventors: David J. Yang, Dongfang Yu, Andrew S. Thompson, F. David Rollo -
Publication number: 20170281806Abstract: Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are methods of imaging a peripheral blood vessel in a subject by using a detectable amount of a radionuclide-labeled chelator-glucose analog conjugate. Also disclosed are methods of distinguishing a false positive nuclear cardiology scan from a true positive nuclear cardiology scan, methods of diagnosing congestive heart failure or cardiac ischemia that involve imaging a subject that has been administered a radionuclide-labeled chelator-glucose analog conjugate, and methods to distinguish viable from nonviable myocardium.Type: ApplicationFiled: June 20, 2017Publication date: October 5, 2017Inventors: F. David ROLLO, Jerry L. BRYANT
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EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS
Publication number: 20130039853Abstract: Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.Type: ApplicationFiled: July 31, 2012Publication date: February 14, 2013Inventors: David J. Yang, Dongfang Yu, Andrew S. Thompson, F. David Rollo -
Patent number: 8308694Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: GrantFiled: December 27, 2011Date of Patent: November 13, 2012Assignee: B. Braun Melsungen AGInventors: Thomas C. Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20120238966Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: ApplicationFiled: April 20, 2012Publication date: September 20, 2012Applicant: B. BRAUN MELSUNGEN AGInventors: Thomas C. Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20110166526Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: ApplicationFiled: March 18, 2011Publication date: July 7, 2011Inventors: Thomas C. Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20110085969Abstract: Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are methods of imaging a peripheral blood vessel in a subject by using a detectable amount of a radionuclide-labeled chelator-glucose analog conjugate. Also disclosed are methods of distinguishing a false positive nuclear cardiology scan from a true positive nuclear cardiology scan, methods of diagnosing congestive heart failure or cardiac ischemia that involve imaging a subject that has been administered a radionuclide-labeled chelator-glucose analog conjugate, and methods to distinguish viable from nonviable myocardium.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Inventors: F. David Rollo, Jerry L. Bryant
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Publication number: 20100137815Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: ApplicationFiled: August 1, 2009Publication date: June 3, 2010Inventors: Thomas C. Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20090177167Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: ApplicationFiled: December 1, 2008Publication date: July 9, 2009Inventors: Thomas Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Patent number: 7534231Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: GrantFiled: February 24, 2005Date of Patent: May 19, 2009Assignee: Injectimed, Inc.Inventors: Thomas C Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20060189934Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: ApplicationFiled: February 24, 2005Publication date: August 24, 2006Inventors: Thomas Kuracina, Randall Ohnemus, Craig Smith, Richard Cohen, David Rollo
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Patent number: 6860871Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: GrantFiled: May 21, 2003Date of Patent: March 1, 2005Assignee: Injectimed, Inc.Inventors: Thomas C Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20030195479Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: ApplicationFiled: May 21, 2003Publication date: October 16, 2003Inventors: Thomas C. Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Patent number: 6629959Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: GrantFiled: April 30, 2001Date of Patent: October 7, 2003Assignee: InjectiMed, Inc.Inventors: Thomas C. Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20030013950Abstract: A gamma camera system is described in which counts are scatter corrected using multiple windows located in the vicinity of a photopeak. Pixel data is thereby scatter corrected prior to image formation. The system is useful-in nuclear medicine studies using dual isotopes such as stress and lung perfusion studies, wherein count data of the multiple isotopes are acquired simultaneously.Type: ApplicationFiled: June 27, 2001Publication date: January 16, 2003Inventors: David Rollo, Horace Hines, David E. Coles
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Publication number: 20020004650Abstract: A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.Type: ApplicationFiled: April 30, 2001Publication date: January 10, 2002Inventors: Thomas C. Kuracina, Randall E. Ohnemus, Craig W. Smith, Richard Cohen, David Rollo
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Publication number: 20010023387Abstract: A personal tour guide system for providing a user selected information about a selected region. The system comprises a sighting device that is used to view the selected object. The sighting device provides bearing and tilt information that is used by a CPU to determine the location of the object being viewed relative to the user. The CPU uses this information and also the known position of the user in order to determine the specific location of the selected object being viewed. The system further comprises a storage device in communication with the CPU. The CPU determines the location of the selected object and retrieves such information about the selected object from the storage device and presents this information to the user.Type: ApplicationFiled: April 11, 2001Publication date: September 20, 2001Inventor: David Rollo