Abstract: A method for classifying domains to malware families includes identifying a corpus of malicious domains, identifying one or more suspicious domains, extracting a timeframe corresponding to the one or more suspicious domains, calculating a rank coefficient between the one or more suspicious domains and a current seed domain of the corpus of malicious domains, determining whether the rank correlation coefficient exceeds a rank threshold for the one or more suspicious domains, comparing a number of suspicious domains whose correlation coefficients exceed the rank threshold to a relation threshold, and responsive to determining the number of suspicious domains whose correlation coefficients exceed the rank threshold exceeds the relation threshold, applying a tag to the suspicious domains indicating that the one or more suspicious domains correspond to a same malware family as the current seed domain.

Abstract: The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK.

Abstract: The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK.

Abstract: Various computerized servers such as, for example, a computerized server including: a) an interview engine configured to prompt data input pertaining to a user and the user's assets from a user connected to the server; b) an analytic module adapted to apply a set of predetermined rules to said data input, formulate an asset re-allocation suggestion and to output an estimate of potential savings from implementing said asset re-allocation suggestion; and c) a display engine configured to present the estimate to the user are disclosed.

Abstract: The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.

Abstract: The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.

Abstract: Systems and methods for servicing a user seeking a service over a computer network. In one embodiment the user visits a website of an administrative processing system which performs administrative processing for a plurality of service providers, including service provider(s) which will provide the service(s) to the user. In one embodiment, the administrative processing includes an interactive chat-like interview with the user. In one embodiment the administrative processing system is paid by the user and the payment is shared with the provider(s) who serviced the user.

Abstract: The invention is directed to methods for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening assays, including high throughput screening techniques, in which the test substances are tested for their ability to promote resistance to oxidative stress by activating one or more points of the integrated stress response pathway, while not causing stress.

Abstract: The present invention is directed to a system and method for using cascading style sheets to theme and customize a store whose actual generation and control flow is on a central server. The system provides for a server operator to host a store web page that links to a seller's website. The themes and appearance of the pages on the store web page are selected by the seller. Once selected, the themes are hyperlinked to the seller's site, enabling the seller to offer for sale the sale operator's products. The method contemplated provides for increased sales due to artificial competition between sellers for the server operator, statistical analyses detail which marketing initiatives are most effective, as well as increasing product distribution by offering the same product for sale from the same website while appearing to be a second, alternative website.

Abstract: The invention is directed to methods and reagents for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening assays, including high throughput screening techniques, in which the test substances are tested for their ability to promote resistance to oxidative stress by inhibiting the activity of GADD34L, and thereby inhibiting the dephosphorylation of eIF2?, while not causing stress.

Abstract: The invention is directed to methods and reagents for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening assays, including high throughput screening techniques, in which the test substances are tested for their ability to promote resistance to oxidative stress by inhibiting the activity of GADD34L, and thereby inhibiting the dephosphorylation of eIF2&agr;, while not causing stress.

Abstract: The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.

Abstract: The invention is directed to methods for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening assays, including high throughput screening techniques, in which the test substances are tested for their ability to promote resistance to oxidative stress by activating one or more points of the integrated stress response pathway, while not causing stress.