Patents by Inventor David S. Baskin

David S. Baskin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10555936
    Abstract: Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase-specific compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas. Also disclosed are methods employing the novel targeted chemotherapeutics with one or more conventional anti-cancer therapies, including, for example, radiotherapy, or multi-drug regimens.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: February 11, 2020
    Assignee: THE METHODIST HOSPITAL
    Inventors: David S. Baskin, Martyn Alun Sharpe
  • Publication number: 20150216975
    Abstract: Various embodiments of the present invention provide therapeutic compositions for specifically targeting tumor cells. In some embodiments, the therapeutic compositions generally include: (1) a plurality of nanovectors; (2) one or more active agents associated with the nanovectors, where the one or more active agents have activity against the tumor cells; (3) one or more active agent enhancers associated with the nanovectors; and (4) one or more targeting agents associated with the nanovectors, where the one or more targeting agents have recognition activity for one or more markers of the tumor cells. Additional embodiments of the present invention pertain to methods of targeting tumor cells in a subject by administering one or more of the aforementioned therapeutic compositions to the subject. Further embodiments of the present invention pertain to methods of formulating the aforementioned therapeutic compositions for targeting tumor cells in a subject in a personalized manner.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 6, 2015
    Applicants: William Marsh Rice University, The Methodist Hospital Research Institute
    Inventors: David S. Baskin, Daniela Marcano, Martyn A. Sharpe, James M. Tour
  • Publication number: 20140323513
    Abstract: Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase-specific compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas. Also disclosed are methods employing the novel targeted chemotherapeutics with one or more conventional anti-cancer therapies, including, for example, radiotherapy, or multi-drug regimens.
    Type: Application
    Filed: April 30, 2014
    Publication date: October 30, 2014
    Inventors: David S. Baskin, Martyn Alun Sharpe
  • Publication number: 20140154269
    Abstract: In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.
    Type: Application
    Filed: April 26, 2012
    Publication date: June 5, 2014
    Applicants: The Methodist Hospital Research Institute, William Marsh Rice University
    Inventors: James M. Tour, Jacob Berlin, Daniela Marcano, David S. Baskin, Martyn A. Sharpe
  • Publication number: 20130157261
    Abstract: Disclosed are compositions and methods for quantitation and calibration of images in fluorescence microscopy. Also provided are tissue phantoms that contain known amount(s) of fluorophore standard(s), as well as components and diagnostic kits containing the same for use in various histological analyses. In certain embodiments, three distinct nucleic-acid based assays provide improvements over conventional TUNEL methods to facilitate precise quantitation of a variety of nucleic acids obtained from a biological sample.
    Type: Application
    Filed: June 1, 2012
    Publication date: June 20, 2013
    Applicant: The Methodist Hospital Research Institute
    Inventors: Martyn Alun Sharpe, David S. Baskin