Patents by Inventor David S. Douce
David S. Douce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11854780Abstract: Exemplary embodiments provide methods, mediums, and systems for comparing a sample of interest to a library of known compounds to quickly determine how similar the sample is to the compounds in the library. Peaks of interest in the sample data are compared to corresponding peaks in the library compound data. These peaks may be represented as vectors, and an angle between the sample vector and the library vector may be used as a similarity metric. In some embodiments, a cosine similarity may be calculated for the vectors. If the similarity score for a given library compound/sample pair exceed a threshold, then the system determines that the library compound and the sample are similar and takes appropriate action. Various parameters associated with the comparison can be adjusted in order to improve the quality of the results and/or the efficiency of the process.Type: GrantFiled: October 13, 2021Date of Patent: December 26, 2023Assignee: WATERS TECHNOLOGIES IRELAND LIMITEDInventors: Nathaniel Martin, Nicola Lumley, David S. Douce, David Jackson
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Publication number: 20220115220Abstract: Exemplary embodiments provide methods, mediums, and systems for comparing a sample of interest to a library of known compounds to quickly determine how similar the sample is to the compounds in the library. Peaks of interest in the sample data are compared to corresponding peaks in the library compound data. These peaks may be represented as vectors, and an angle between the sample vector and the library vector may be used as a similarity metric. In some embodiments, a cosine similarity may be calculated for the vectors. If the similarity score for a given library compound/sample pair exceed a threshold, then the system determines that the library compound and the sample are similar and takes appropriate action. Various parameters associated with the comparison can be adjusted in order to improve the quality of the results and/or the efficiency of the process.Type: ApplicationFiled: October 13, 2021Publication date: April 14, 2022Inventors: Nathaniel Martin, Nicola Lumley, David S. Douce, David Jackson
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Patent number: 11282691Abstract: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.Type: GrantFiled: December 21, 2018Date of Patent: March 22, 2022Assignee: Micromass UK LimitedInventors: Stevan Bajic, David S. Douce
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Publication number: 20210066059Abstract: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.Type: ApplicationFiled: December 21, 2018Publication date: March 4, 2021Inventors: Stevan Bajic, David S. Douce
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Patent number: 10859544Abstract: A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.Type: GrantFiled: September 24, 2019Date of Patent: December 8, 2020Assignee: Micromass UK LimiteInventors: Stevan Bajic, David S. Douce, Gordon A. Jones
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Publication number: 20200018733Abstract: A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.Type: ApplicationFiled: September 24, 2019Publication date: January 16, 2020Applicant: Micromass UK LimitedInventors: Stevan Bajic, David S. Douce, Gordon A. Jones
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Patent number: 10466213Abstract: A secondary ultrasonic nebulization device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulize the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.Type: GrantFiled: December 21, 2016Date of Patent: November 5, 2019Assignee: MICROMASS UK LIMITEDInventors: Stevan Bajic, David S Douce, Gordon A Jones
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Publication number: 20170176401Abstract: A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.Type: ApplicationFiled: December 21, 2016Publication date: June 22, 2017Inventors: Stevan BAJIC, David S DOUCE, Gordon A JONES
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Patent number: 9651527Abstract: An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2. A counter electrode 4 is arranged downstream of a tip of the electrospray emitter 2 and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer.Type: GrantFiled: December 2, 2015Date of Patent: May 16, 2017Assignee: Micromass UK LimitedInventors: David S. Douce, John Chipperfield, Stevan Bajic, James Murphy, David Gordon
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Publication number: 20160153944Abstract: An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2. A counter electrode 4 is arranged downstream of a tip of the electrospray emitter 2 and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer.Type: ApplicationFiled: December 2, 2015Publication date: June 2, 2016Inventors: David S. Douce, John Chipperfield, Stevan Bajic, James Murphy, David Gordon
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Patent number: 8785843Abstract: A sampling cone of a mass spectrometer is disclosed having a metallic boride coating such as titanium diboride.Type: GrantFiled: June 20, 2013Date of Patent: July 22, 2014Assignee: Micromass UK LimitedInventors: Gordon A. Jones, David S. Douce, Amir Farooq
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Patent number: 8742337Abstract: A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionization (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.Type: GrantFiled: June 27, 2013Date of Patent: June 3, 2014Assignee: Micromass UK LimitedInventors: Gordon A. Jones, David S. Douce, Amir Farooq
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Publication number: 20130299691Abstract: A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.Type: ApplicationFiled: June 27, 2013Publication date: November 14, 2013Inventors: Gordon A. Jones, David S. Douce, Amir Farooq
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Publication number: 20130277550Abstract: A sampling cone of a mass spectrometer is disclosed having a metallic boride coating such as titanium diboride.Type: ApplicationFiled: June 20, 2013Publication date: October 24, 2013Inventors: Gordon A. Jones, David S. Douce, Amir Farooq
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Patent number: 8476587Abstract: A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.Type: GrantFiled: November 11, 2011Date of Patent: July 2, 2013Assignee: Micromass UK LimitedInventors: Gordon A. Jones, David S. Douce, Amir Farooq
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Patent number: 8471198Abstract: A mass spectrometer includes an ion source, which includes a coating or surface formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.Type: GrantFiled: November 11, 2011Date of Patent: June 25, 2013Assignee: Micromass UK LimitedInventors: Gordon A. Jones, David S. Douce, Amir Farooq
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Publication number: 20120292500Abstract: A mass spectrometer includes an ion source, which includes a coating or surface formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.Type: ApplicationFiled: November 11, 2011Publication date: November 22, 2012Applicant: MICROMASS UK LIMITEDInventors: Gordon A. Jones, David S. Douce, Amir Farooq
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Publication number: 20120286152Abstract: A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.Type: ApplicationFiled: November 11, 2011Publication date: November 15, 2012Applicant: MICROMASS UK LIMITEDInventors: Gordon A. Jones, David S. Douce, Amir Farooq