Abstract: Provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and their use in directing immune responses to target cells. The compositions have uses that include treating hyperproliferative disorders such as cancer. The provided methods generally include the use of a CAR cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or redirect CAR cell-mediated immune response in vitro and in vivo. In some embodiments, the CAR cell comprises a genetic modification to reduce or eliminate the expression of a targeted antigenic determinant.

Abstract: An improved linearized flow control valve assembly maintains a substantially consistent linear relationship between the input driving device (e.g., motor shaft) and the throughput of fluid through a valved passageway and the angle of the valve member within the passageway. Additionally, an improved linearized flow control valve assembly includes a valve position detector and signal generator which determines the position of the valve member and produces a signal representative of said position. The valve position detector and signal generator is adapted to interface with the linearizing mechanism of the valve assembly and generate the output signal as a function of a linear displacement associated with the linearizing mechanism.