Abstract: The present disclosure describes a cart having an adjustable handle system, the cart having: a chassis supported on wheels; a horizontal work surface having a perimeter defined by at least a front edge, a rear edge, and two side edges; a stationary handle connected to, and extending along the perimeter of the horizontal work surface from an origination point located on the rear edge to a connecting point located on one of the two side edges; a moveable handle axially coupled to the stationary handle at the connecting point and extending along the perimeter of the horizontal work surface from the connecting point to an end point located on the front edge; and an adjustable connecting device connecting the moveable handle to the stationary handle at the connecting point and controlling the angular position of the moveable handle relative to the stationary handle.

Abstract: The present disclosure describes a cart having an adjustable handle system, the cart having: a chassis supported on wheels; a horizontal work surface having a perimeter defined by at least a front edge, a rear edge, and two side edges; a stationary handle connected to, and extending along the perimeter of the horizontal work surface from an origination point located on the rear edge to a connecting point located on one of the two side edges; a moveable handle axially coupled to the stationary handle at the connecting point and extending along the perimeter of the horizontal work surface from the connecting point to an end point located on the front edge; and an adjustable connecting device connecting the moveable handle to the stationary handle at the connecting point and controlling the angular position of the moveable handle relative to the stationary handle.

Abstract: A system and method for modeling a blood glucose (BG) level of an individual is presented. A continuous glucose monitor (CGM) device is configured to monitor a blood glucose level of the individual. A processor is configured to receive CGM data of the individual from the CGM device, smooth the CGM data into a plurality of continuous curves, and generate an individual-level model of a BG profile of the individual using the plurality of continuous curves. The processor is configured to estimate the average blood glucose curve and inter-day variance-covariance of BG within the individual using the individual-level model, and generate a report based on the average blood glucose curve and inter-day variance-covariance of BG within the individual.

Abstract: A method and system for performing a clinical trial having a reduced placebo effect is disclosed. The method includes randomizing study participants into three or more treatment groups and performing a first phase of testing on the groups. In a typical embodiment, the first phase of testing includes administering an active treatment to a first group, and administering a placebo to a second group and to a third group. Responders and non-responders are determined for each group. A second phase of testing is then performed. The second phase of testing includes administering the placebo to non-responders in the first group, administering the active treatment to non-responders in the second group, and administering the placebo to non-responders in the third group. The data from the first phase of testing and from the second phase of testing is pooled and analyzed to determine response rates to active treatment and placebo.

Abstract: A method and system for performing a clinical trial having a reduced placebo effect is disclosed. The method includes randomizing study participants into three or more treatment groups and performing a first phase of testing on the groups. In a typical embodiment, the first phase of testing includes administering an active treatment to a first group, and administering a placebo to a second group and to a third group. Responders and non-responders are determined for each group. A second phase of testing is then performed. The second phase of testing includes administering the placebo to non-responders in the first group, administering the active treatment to non-responders in the second group, and administering the placebo to non-responders in the third group. The data from the first phase of testing and from the second phase of testing is pooled and analyzed to determine response rates to active treatment and placebo.

Abstract: A method and system for performing a clinical trial having a reduced placebo effect is disclosed. The method includes randomizing study participants into three or more treatment groups and performing a first phase of testing on the groups. In a typical embodiment, the first phase of testing includes administering an active treatment to a first group, and administering a placebo to a second group and to a third group. Responders and non-responders are determined for each group. A second phase of testing is then performed. The second phase of testing includes administering the placebo to non-responders in the first group, administering the active treatment to non-responders in the second group, and administering the placebo to non-responders in the third group. The data from the first phase of testing and from the second phase of testing is pooled and analyzed to determine response rates to active treatment and placebo.

Abstract: The present invention provides loading and unloading mechanisms, and data drives for data storage cartridges. Embodiments of the cartridge loading and unloading mechanisms for a data storage cartridge may: operate in a manner such that the drive door of the data drive may be fully closed before the disk medium is exposed, e.g., before opening of the associated shutter of the cartridge; be powered by the same drive motor assembly that is used to move or transport the cartridge to the optical head assembly used for writing and/or reading of data from the disk medium of the cartridge; and may fit within a standard configuration for a data drive. Embodiments of the cartridge loading and unloading mechanisms, as well as the data drives, may provide reliable operation, ease of assembly, and of the parts and components necessary for the reliable operation, and positive data cartridge positioning, as well as minimizing backlash in the drive motor/gear assembly.

Abstract: A method and system for performing a clinical trial having a reduced placebo effect is disclosed. The method includes randomizing study participants into three or more treatment groups and performing a first phase of testing on the groups. In a typical embodiment, the first phase of testing includes administering an active treatment to a first group, and administering a placebo to a second group and to a third group. Responders and non-responders are determined for each group. A second phase of testing is then performed. The second phase of testing includes administering the placebo to non-responders in the first group, administering the active treatment to non-responders in the second group, and administering the placebo to non-responders in the third group. The data from the first phase of testing and from the second phase of testing is pooled and analyzed to determine response rates to active treatment and placebo.

Abstract: A method and system for performing a clinical trial having a reduced placebo effect is disclosed. The method includes randomizing study participants into three or more treatment groups and performing a first phase of testing on the groups. In a typical embodiment, the first phase of testing includes administering an active treatment to a first group, and administering a placebo to a second group and to a third group. Responders and non-responders are determined for each group. A second phase of testing is then performed. The second phase of testing includes administering the placebo to non-responders in the first group, administering the active treatment to non-responders in the second group, and administering the placebo to non-responders in the third group. The data from the first phase of testing and from the second phase of testing is pooled and analyzed to determine response rates to active treatment and placebo.

Abstract: The present invention provides loading and unloading mechanisms for data storage cartridges, drive door mechanisms for data drives, and data drives comprising such loading and unloading and/or drive door mechanisms. Embodiments of the cartridge loading and unloading mechanisms, drive door mechanisms and/or data drives, of the present invention can operate in a manner such that the drive door of the data drive is fully closed before the disk medium is exposed, e.g., before opening of the associated shutter of the cartridge. An embodiment of the cartridge loading and unloading mechanism of the present invention can be powered by the same drive motor assembly that is used to move or transport the cartridge to the optical head assembly used for writing and/or reading of data from the disk medium of the cartridge. Embodiments of the cartridge loading and unloading mechanisms and drive door mechanisms of the present invention can fit within a standard configuration for a data drive.

Abstract: A method and system for performing a clinical trial having a reduced placebo effect is disclosed. The method includes randomizing study participants into three or more treatment groups and performing a first phase of testing on the groups. In a typical embodiment, the first phase of testing includes administering an active treatment to a first group, and administering a placebo to a second group and to a third group. Responders and non-responders are determined for each group. A second phase of testing is then performed. The second phase of testing includes administering the placebo to non-responders in the first group, administering the active treatment to non-responders in the second group, and administering the placebo to non-responders in the third group. The data from the first phase of testing and from the second phase of testing is pooled and analyzed to determine response rates to active treatment and placebo.