Patents by Inventor David Siesel

David Siesel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS OF MAKING CFTR MODULATORS
    Publication number: 20230399343
    Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 4, 2023
    Publication date: December 14, 2023
    Inventors: Paul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
  • Process of making CFTR modulators
    Patent number: 11584761
    Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: February 21, 2023
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
  • PROCESS OF MAKING CFTR MODULATORS
    Publication number: 20210047345
    Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: August 13, 2020
    Publication date: February 18, 2021
    Inventors: Paul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
  • Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
    Patent number: 9776968
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 3, 2017
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: David Siesel
  • PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
    Publication number: 20170158676
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Application
    Filed: March 17, 2016
    Publication date: June 8, 2017
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventor: David Siesel
  • PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
    Publication number: 20160200712
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Application
    Filed: March 17, 2016
    Publication date: July 14, 2016
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventor: David Siesel
  • PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
    Publication number: 20140121379
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Application
    Filed: October 23, 2013
    Publication date: May 1, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventor: David Siesel
  • Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
    Patent number: 8592602
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: November 26, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: David Siesel
  • PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
    Publication number: 20120203006
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Application
    Filed: April 19, 2012
    Publication date: August 9, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventor: David Siesel
  • PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
    Publication number: 20120190856
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Application
    Filed: January 17, 2012
    Publication date: July 26, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventor: David Siesel
  • Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
    Patent number: 8124781
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: February 28, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: David Siesel
  • SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION
    Publication number: 20100256375
    Abstract: Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R1, R2, R3, R4, a, b, and c are defined herein
    Type: Application
    Filed: June 18, 2010
    Publication date: October 7, 2010
    Inventors: Martin Dimitroff, Bridget R. Miller, Brady S. Stillwell, David A. Siesel, Tyson Swiftney, Brian Diaz, Danlin Gu, Jonathan P. van Dyck, David Ryckman, Daniel J. Poon, Teresa E. Pick
  • Substituted benzimidazoles and methods of preparation
    Patent number: 7767820
    Abstract: Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R1, R2, R3, R4, a, b, and c are defined herein
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: August 3, 2010
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Martin Dimitroff, Bridget R. Miller, Brady S. Stillwell, David A. Siesel, Tyson Swiftney, Brian Diaz, Danlin Gu, Jonathan P. Van Dyck, David Ryckman, Daniel J. Poon, Teresa E. Pick
  • PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
    Publication number: 20100036130
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Application
    Filed: May 29, 2009
    Publication date: February 11, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventor: David Siesel
  • PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
    Publication number: 20090176989
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Application
    Filed: December 4, 2008
    Publication date: July 9, 2009
    Inventor: David Siesel
  • Substituted benzimidazoles and methods of preparation
    Publication number: 20080287682
    Abstract: Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R1, R2, R3, R4, a, b, and c are defined herein
    Type: Application
    Filed: May 5, 2008
    Publication date: November 20, 2008
    Inventors: Martin Dimitroff, Bridget R. Miller, Brady S. Stillwell, David A. Siesel, Tyson Swiftney, Brian Diaz, Danlin Gu, Jonathan P. van Dyck, David Ryckman, Daniel J. Poon, Teresa E. Pick
  • Substituted benzimidazoles and methods of preparation
    Publication number: 20070049622
    Abstract: Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R1, R2, R3, R4, a, b, and c are defined herein
    Type: Application
    Filed: August 30, 2006
    Publication date: March 1, 2007
    Inventors: Martin Dimitroff, Bridget Miller, Brady Stillwell, David Siesel, Tyson Swiftney, Brian Diaz, Danlin Gu, Jonathan van Dyck, David Ryckman, Daniel Poon, Teresa Pick