Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: This disclosure relates to validating data written to logical blocks on a storage subsystem adapted so that during write operations an additional sequence code is written to each logical block of data, where the sequence code remains constant for each write operation batch and where the sequence code is incremented for each new write operation batch. A sequence code verification system may comprise a data reader, a validity engine, and an error notifier. The data reader may read sequence codes from consecutive logical blocks. The validity engine may invalidate write operations in response to checking data validity by applying comparison operations to sequence codes and block offsets of batch write operations. The error notifier may notify a user of an error for each invalidated write operation batch.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The invention provides methods and compositions for inhibiting CD 38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

Abstract: Structure coated with a biocidal foul release coating system, the structure being obtained by a. providing a substrate, b. coating the substrate with a first coating layer, c. applying at least one subsequent coating layer on top of the first coating layer, the first coating layer containing a biocide, the subsequent coating layer(s) containing less biocide than the first coating layer and which is(are)free or substantially free of biocide, and wherein the first and the subsequent coating layer(s) form a biocidal foul release coating system showing a controlled leaching of the biocide.

Abstract: A data receiver module receives, at a storage device simulator, a data transmission from a storage controller being tested. The data transmission includes data and metadata. The metadata is associated with the data. A signature receiver module receives a signature from the storage controller as part of the data transmission. The signature is used to distinguish the metadata from the data. A data/metadata determination module examines the data transmission and determines data from metadata using the signature. A metadata storage module stores the metadata of the data transmission on the storage device simulator in response to the data transmission including metadata. The data storage simulator includes a data storage device. A data discard module discards the data of the data transmission in response to the data transmission including data.

Abstract: Systems and methods for facilitating diagnosis and product identification for patients requiring continence products. Embodiments of the invention have been particularly developed there by to provide a software application (for example an iOS or Android application) thereby to assist a clinician and/or patient in identifying appropriate continence products for a given set of patient requirements. While some embodiments will be described herein with particular reference to that application, it will be appreciated that the invention is not limited to such a field of use, and is applicable in broader contexts.

Abstract: A dental implant comprising an implant body which has an asymmetric root portion receivable in an asymmetric open root cavity of the patient and engagement means on the asymmetric root portion to at least in part engage a surface of the root cavity so as to prevent or inhibit unintentional extraction. The asymmetric root portion is complementarily shaped to fit the said asymmetric open root cavity, thus substantially dispensing with the need for protracted preparation of the root cavity and providing substantially immediate stability for the prosthetic tooth.

Abstract: A data receiver module receives, at a storage device simulator, a data transmission from a storage controller being tested. The data transmission includes data and metadata. The metadata is associated with the data. A signature receiver module receives a signature from the storage controller as part of the data transmission. The signature is used to distinguish the metadata from the data. A data/metadata determination module examines the data transmission and determines data from metadata using the signature. A metadata storage module stores the metadata of the data transmission on the storage device simulator in response to the data transmission including metadata. The data storage simulator includes a data storage device. A data discard module discards the data of the data transmission in response to the data transmission including data.

Abstract: Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

Abstract: A method for selecting a preferred cache for the download of digital data from a plurality of caches is disclosed. The method comprises the steps of requesting an address of the preferred cache and selecting the preferred cache from the plurality of caches. The selection of the preferred cache is derived from a location identifier of a client requesting the download of the digital data.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The invention relates to methods and kits for measuring enzyme activity, including enzymes that produce nicotinamide.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.

Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.