Abstract: A method of using a catheter assembly for inserting in a fluid filled space in a body includes providing a main body having a first end portion and a second end portion. The first end portion is positioned within the fluid filled space. The second end portion is adjusted to extend outwardly from the fluid filled space when the first end portion is positioned within the fluid filled space. A catheter tip is connected to the second end portion of the main body. The catheter tip includes a housing having a cavity defined therein and a rotating element positioned within the fluid filled space. The rotating element is rotated within the cavity of the housing to impart movement of the first end portion of the main body within the fluid filled space.

Abstract: Disclosed are devices and methods for optimizing a protective helmet or other item of protective clothing with one or more enhanced principal impact zones and/or impact elements that incorporate protective features that can be particularized to a specific player-position and/or the individual behavior of a specific player or wearer.

Abstract: Described herein are systems, methods, devices, and other techniques for implementing smart windows, smart home systems that include smart windows, and user devices and applications for control thereof. A smart window, or photovoltaic window, may include a photovoltaic configured to generate electrical power from incident light onto the photovoltaic window, store the electrical power, and send the electrical power to an electronics package or various electrical loads including a wireless communication system, sensors, or window functions. The photovoltaic window may communicate with various smart home system devices such as hub devices and user devices, which may include the reception of control data at the photovoltaic window and the transmission of sensor data captured by the window sensors.

Abstract: Luminaires are described herein employing waveguides and associated architectures for dynamic alteration of illuminance distribution patterns. The waveguide includes a light extraction component. The waveguide transmits light from a light source to the light extraction component by total internal reflection (TIR). The light extraction component includes one or more reversibly moveable surfaces for altering illuminance distribution patterns of the luminaire in response to one or more forces applied to the light extraction component by a force application assembly of the luminaire.

Abstract: A method can include intercepting, by an interceptor positioned between a transfer system and a transfer settlement system, a transaction prior to the transaction being provided to the transfer settlement system. The method can include confirming that data from the transaction matches information in an immutable ledger to which parameters of the transaction have been provided by a notary system that confirms the parameters of the transaction and applies a signature using a private key to the transaction in response to confirming the parameters. The method can include, in response to confirming that the data matches the information, providing the transaction for settlement by the transfer settlement system.

Abstract: An online system accesses a list of features used as input into a predictor to predict a performance metric for content presented to users. The online system computes importance scores for one or more of the features. A ranked list of categories is created, with each category having one or more sub-categories. For each feature having a computed importance score, the online system assigns, for each attribute in the ranked list of attributes for that feature, the feature to a sub-category in one of the categories in the ranked list of categories that has the same rank as the attribute in the ranked list of attributes for the feature, where the sub-category is associated with a label that corresponds with the attribute. For each sub-category in each category, a cumulative score is computed for the sub-category based on the importance scores of the features of that sub-category.

Abstract: The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Abstract: An online system ranks content eligible for presentation to an online system user based on a prediction made by a general model or a specific model indicating a likelihood that the user will interact with a content item, in which the specific model has a higher latency than the general model. The online system determines which prediction to use for the ranking by balancing the benefit of a more accurate prediction made by the specific model against the higher latency of the specific model. The online system outputs the predicted likelihood from one of the models based on the determination, ranks content items eligible for presentation to the user based on the output, and selects content item(s) for presentation to the user based on the ranking. The online system may log the predicted likelihoods from both models, the outputted predicted likelihood, and information describing the performance of the content item.

Abstract: A transaction system can include a computing device with a communication port, a processor device, and a non-transitory computer-readable storage memory. The communication port can communicate data with other computing devices. The non-transitory computer-readable storage memory includes code that is executable by the processor device to perform operations. The operations include receiving parameters of a transfer, verifying the transfer using a multi-factor authentication process, in response to verifying the transfer, using a private key to countersign the transfer and return, via the communications port, a signed transfer package for execution of the transfer, and providing, via the communications port, the parameters of the transfer and countersign data to an immutable ledger.

Abstract: Database systems and methods are provided for visual design and customization of processes for web applications. A method involves identifying a plurality of configured actions added to an aggregate action component region on a graphical user interface (GUI) display, automatically generating configured code for each of the configured actions in accordance with a respective user configuration of the respective configured action, identifying a user configuration associated with the aggregate action component, automatically generating aggregate action component code configurable to cause a browser application to initiate the configured code for each of the configured actions in parallel in accordance with the user configuration, and automatically generating process flow code including a reference to the aggregate action component code in accordance with a sequence defined for a web page.

Abstract: Account permissions and data accessibility can be modified based on level of confidence for a login attempt to the account. User activity observations corresponding to one or more login attempts to access a user account can be stored. A confidence score associated with a successful login attempt of the user account can be determined. The confidence score is based on the user activity observations. A level of access to an application with functions and data for the user account can be determined. The level of access is based on the confidence score. The level of access is associated with the functions and the data that are executable and accessible subsequent to the successful login attempt.

Abstract: A source of a login attempt to a user account can be classified using machine learning. For example, a computing system can input user activity observations associated with one or more login attempts to one or more user accounts into a trained machine learning model. One or more distinguishing factors for the one or more login attempts can be received from the trained machine learning model. The computing system can determine a source of a current login attempt by applying a clustering algorithm to current values of the one or more distinguishing factors. The current values may be derived from current user activity observations associated with the current login attempt. The computing system can determine an authentication level for the current login attempt to the user account based on the source of the current login attempt.

Abstract: A vacuum system non-return valve includes a baffle for extending across a flow path in the vacuum system and a valve member. The baffle has an aperture, a perimeter of the aperture has a valve seat. The valve member has a curved sealing surface configured to mate with the valve seat. The valve member and aperture are configured such that the valve member obscures the aperture and seals with the valve seat to impede a flow of fluid in a closed position and is displaceable in use to move away from the valve seat and allow a fluid flow in an open position; at least a portion of the surface of the baffle surrounding the aperture slopes towards the inlet end of the valve such that the aperture is smaller at the inlet end than it is at the outlet end.

Abstract: A pump and method for pumping a gas are disclosed. The pump comprises a rotor and a stator. At least one of the rotor or stator comprises at least one liquid opening configured for fluid communication with a liquid source. The liquid opening is configured such that in response to a driving force exerted on liquid from the liquid source a stream of liquid is output from the opening, the stream of liquid forming a liquid blade between the rotor and the stator, gas confined by said stator, said rotor and said liquid blade being driven through said pump from a gas inlet towards a gas outlet.

Abstract: Luminaires are described herein employing waveguides and associated architectures for dynamic alteration of illuminance distribution patterns. The waveguide includes a light extraction component. The waveguide transmits light from a light source to the light extraction component by total internal reflection (TIR). The light extraction component includes one or more reversibly moveable surfaces for altering illuminance distribution patterns of the luminaire in response to one or more forces applied to the light extraction component by a force application assembly of the luminaire.

Abstract: Account permissions and data accessibility can be modified based on level of confidence for a login attempt to the account. User activity observations corresponding to one or more login attempts to access a user account can be stored. A confidence score associated with a successful login attempt of the user account can be determined. The confidence score is based on the user activity observations. A level of access to an application with functions and data for the user account can be determined. The level of access is based on the confidence score. The level of access is associated with the functions and the data that are executable and accessible subsequent to the successful login attempt.

Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: Account permissions and data accessibility can be modified based on level of confidence for a login attempt to the account. User activity observations corresponding to one or more login attempts to access a user account can be stored. A confidence score associated with a successful login attempt of the user account can be determined. The confidence score is based on the user activity observations. A level of access to an application with functions and data for the user account can be determined. The level of access is based on the confidence score. The level of access is associated with the functions and the data that are executable and accessible subsequent to the successful login attempt.

Abstract: An online system accesses a model attribute store, which stores configuration information and model performance scores for a plurality of models, each model used to predict performance metrics regarding content from a third party system presented to users of the online system. The online system trains a meta-model classifier using the models in the model attribute store, the meta-model classifier trained to predict, for a candidate model, a predicted model performance score of that candidate model. The online system also generates a plurality of candidate models for input to the meta-model classifier, each of the plurality of candidate models including a distinct set of configuration information. The predicted model performance scores for a selected candidate model in the plurality of candidate models is computed using the meta-model classifier, and the online system transmits a report to the third party system indicating predicted model performance score for the selected candidate model.

Abstract: The present invention is directed towards an electrodepositable coating composition comprising, consisting essentially of, or consisting of an ionic salt group-containing silicone-based main film-forming polymer comprising functional groups; and a curing agent reactive with the functional groups of the ionic salt group-containing silicone-based main film-forming polymer. Also disclosed are coatings, coated substrates, and methods of coating a substrate.